Not just for children: Study shows high prevalence of atopic dermatitis among US adults

October 30, 2018

PHILADELPHIA - As many as 16.5 million adults in America suffer from a skin disease known as atopic dermatitis, an inflammatory disease that results in red, itchy skin. The estimate comes from a new study from the Perelman School of Medicine at the University of Pennsylvania, which also projected 6.6 million of these adults have disease that would be classified as moderate to severe, leading to a decrease in quality of life. Researchers published the findings in the Journal of Investigative Dermatology today.

Atopic dermatitis (AD) is commonly associated with children but can occur at any age. The dry, itchy, red patches can occur anywhere on the skin and tend to flare periodically and unpredictably. There is no cure for the condition, but treatment to control it can involve a gentle skin care regimen including over-the-counter products as well as topical or systemic corticosteroids. In more resistant or severe cases, treatment can include the use of immunosuppressive therapies such as methotrexate, cyclosporine, azathioprine or mycophenolate mofetil. In 2017, the U.S. Food and Drug Administration approved a biologic called dupilumab, which is given by injection and targets the inflammation from the inside-out. It is currently the only FDA-approved medication for treatment of atopic dermatitis and the only biologic available.

"We tend to think of this disease as a children's disease, but our data show that's not the case," said the study's lead author Zelma C. Chiesa Fuxench, MD, MSCE, an assistant professor of Dermatology at Penn. "Our findings show this disease affects seven percent of the population, far more than other inflammatory conditions like psoriasis, which only affects about three percent. Yet psoriasis has eight biologic treatments available for patients, whereas atopic dermatitis only has one that's approved."

The study's senior author was Peck Ong, MD, an associate professor of Clinical Pediatrics at the Keck School of Medicine of the University of Southern California and an attending physician at Children's Hospital Los Angeles.

Researchers surveyed 1,278 adults sampled from the GfK Knowledge Panel, a probability-based online panel that is thought to be representative of the adult population of the United States. Among those respondents, 7.3 percent met the criteria for diagnosis of AD. Sixty percent of those with AD classified as mild, 29 percent as moderate, and 11 percent as severe. Since the panel is representative of the country's population, researchers used U.S. census population data to project that 16.5 million American adults are living with AD, with 6.6 million of those cases being moderate-to-severe. Patients with AD and those with more severe disease also had higher scores in other patient-reported outcome measures, including the Dermatology Life Quality Index, indicating a worse impact on quality of life and an increased likelihood of anxiety or depression as measures by the Hospital Anxiety and Depression Scale.

"These findings show a disconnect between the prevalence of this disease - and its impact on patient quality of life - compared to the resources being dedicated to developing systemic therapies," Chiesa Fuxench said. "With only one approved biologic available, it's clear the need is not being met."

Chiesa Fuxench says the numbers also hint at larger questions about this population, including whether they developed the condition as they got older or whether they had it as children and stopped seeking treatment at some point during their lives due to unhappiness with or poor response to currently available therapies. Many patients, she notes, are told they will grow out of the disease, but these data suggest that may not be the case, and that the disease may change over time. She also notes the medical and social impact of AD can also lead to a financial impact for many patients.

"When these patients experience flare ups, they're more likely to call out of work, avoid going out, or remove themselves from other situations they might typically enjoy," she said. One study from 2017 estimates the annual cost of AD in the United States is $5.3 billion each year, which only further drives home the point.

"Topical and oral corticosteroids don't work for everyone, and even when they do, patients should not be on them long-term," Chiesa Fuxench said. "We need to prioritize our understanding of this complex disease as well as the development of innovative therapies for these patients."
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This study was completed in collaboration with the Asthma and Allergy Foundation of America in partnership with the National Eczema Association, sponsored by Sanofi Genzyme and Regeneron. Sanofi Genzyme and Regeneron manufacture dupilumab, but had no involvement in this research.

Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $7.8 billion enterprise.

The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $405 million awarded in the 2017 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center -- which are recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report -- Chester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; Penn Wissahickon Hospice; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine, and Princeton House Behavioral Health, a leading provider of highly skilled and compassionate behavioral healthcare.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2017, Penn Medicine provided more than $500 million to benefit our community.

University of Pennsylvania School of Medicine

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