RUDN University chemist developed green method for malaria and leprosy drug production

October 30, 2020

A chemist from RUDN University suggested an eco-friendly method for the synthesis of dapsone, a substance that inhibits the growth of malaria and leprosy agents. The main component of the new reaction is hydrogen peroxide that does not form environmentally destructive compounds, and the only by-product is simple water. Unlike other technologies, this method includes only one stage of dapsone production and does not require high temperatures. The catalyst of the reaction can be reused without any loss of efficiency. The results of the work were published in the Microporous and Mesoporous Materials journal.

Many think of leprosy as a disease of the past; however, about 200 thousand cases of it are registered in the world (mainly in India, Brazil, and Nepal) every year. It is treatable with antibiotics that prevent the growth of the Mycobacterium bacteria. On the contrary, malaria is one of the most widely spread diseases in the world with over 200 million cases annually. The spread of its agent (a protist from the genus Plasmodium) also can be inhibited with antibiotics. Dapsone is a safe and available drug that works in both cases and is included in the WHO Model List of Essential Medicines. However, its production is not eco-friendly, as the synthesis reaction requires high temperatures and the use of aggressive acids (such as sulphuric acid). A chemist from RUDN University suggested a green technology of dapsone synthesis that could potentially help expand its production and make the drug available to more patients.

Dapsone or diaminophenyl sulphone consists of two benzene rings with NH2 amino groups. The rings are connected with an oxidized atom of sulfur, or an SO2 group. To obtain dapsone, manufacturers oxidize its precursor in which the bond between the rings is formed by an SH group (sulfur and hydrogen). However, oxidation can also affect sensitive amino groups. Therefore, they have to be protected before the reaction starts--for example, by attaching special protective groups to them. The researcher from RUDN University developed a catalyst that provides for the oxidation of SH groups in the precursor with simple hydrogen peroxide. Hydrogen peroxide is considered the most environmentally friendly oxidizing agent because its only by-product is water. The reaction of oxidation takes place at room temperature, has only one stage, and requires no protection of amino groups.

"None of the earlier dapsone synthesis reactions can be called completely environmentally friendly as they happen in rigid conditions and have several stages: adding protective groups, synthesis, and their removal. This complexity increases the chances of by-products that should be removed from the reaction," said Raphael Luke, Ph.D., the head of the Molecular Design and Synthesis of Innovative Compounds for Medicine Science Center at RUDN University.

His team developed a wolfram-based catalyst from polyoxometalates by replacing certain wolfram atoms with vanadium. This increased the acidic properties of the catalyst and sped up the reaction, allowing it to take place even at low temperatures. To prevent the catalyst from being washed off from the reaction, the chemists encased the new compound in a porous material--a hydrogel made of propanoic acid and acrylamide. Thanks to it, the catalyst can be re-used at least three times without losing its efficiency. The team also identified the most optimal synthesis conditions and reagent concentration and managed to reach 100% oxidation of the dapsone precursor at 25? in only nine hours.

RUDN University

Related Malaria Articles from Brightsurf:

Clocking in with malaria parasites
Discovery of a malaria parasite's internal clock could lead to new treatment strategies.

Breakthrough in malaria research
An international scientific consortium led by the cell biologists Volker Heussler from the University of Bern and Oliver Billker from the UmeƄ University in Sweden has for the first time systematically investigated the genome of the malaria parasite Plasmodium throughout its life cycle in a large-scale experiment.

Scientists close in on malaria vaccine
Scientists have taken another big step forward towards developing a vaccine that's effective against the most severe forms of malaria.

New tool in fight against malaria
Modifying a class of molecules originally developed to treat the skin disease psoriasis could lead to a new malaria drug that is effective against malaria parasites resistant to currently available drugs.

Malaria expert warns of need for malaria drug to treat severe cases in US
The US each year sees more than 1,500 cases of malaria, and currently there is limited access to an intravenously administered (IV) drug needed for the more serious cases.

Monkey malaria breakthrough offers cure for relapsing malaria
A breakthrough in monkey malaria research by two University of Otago scientists could help scientists diagnose and treat a relapsing form of human malaria.

Getting to zero malaria cases in zanzibar
New research led by the Johns Hopkins Center for Communication Programs, Ifakara Health Institute and the Zanzibar Malaria Elimination Program suggests that a better understanding of human behavior at night -- when malaria mosquitoes are biting -- could be key to preventing lingering cases.

Widely used malaria treatment to prevent malaria in pregnant women
A global team of researchers, led by a research team at the Liverpool School of Tropical Medicine (LSTM), are calling for a review of drug-based strategies used to prevent malaria infections in pregnant women, in areas where there is widespread resistance to existing antimalarial medicines.

Protection against Malaria: A matter of balance
A balanced production of pro and anti-inflammatory cytokines at two years of age protects against clinical malaria in early childhood, according to a study led by ISGlobal, an institution supported by ''la Caixa'' Foundation.

The math of malaria
A new mathematical model for malaria shows how competition between parasite strains within a human host reduces the odds of drug resistance developing in a high-transmission setting.

Read More: Malaria News and Malaria Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to