Double headed hydra

October 31, 2000

In the November issue of Genes & Development, Jan Lohmann and Thomas Bosch report their discovery that a novel peptide, HEADY, is a potent inducer of head formation in lower metazoans. Axis formation is one of the first and most important steps in animal development. Many of the signaling peptides responsible for axis specification in flies, worms and mammals are known. However, scientists have long been unsure as to the extent to which signaling peptides play a role in the body axis formation of lower eukaryotic animals.

Using grafting experiments, Lohmann and Bosch show that a secondary head can be induced by HEADY. Donor tissue is treated with HEADY and labeled using fluorescent latex beads prior to transplantation into an unlabeled host. After five days, the transplanted tissue develops into a fluorescent secondary head.

That HEADY acts as a developmental switch to pattern the apical-basal axis of Hydra provides the first insight into how initial asymmetry is specified in lower metazoan animals. Furthermore, it supports the view that peptides have played a key role as developmental signals in metazoan evolution.
-end-


Cold Spring Harbor Laboratory

Related Peptides Articles from Brightsurf:

Peptides+antibiotic combination may result in a more effective treatment for leishmaniasis
A combination of peptides and antibiotics could be key to eliminating the parasite causing leishmaniasis and avoiding the toxicity to people and animals caused by current drugs.

Designer peptides show potential for blocking viruses, encourage future study
Chemically engineered peptides, designed and developed by a team of researchers at Rensselaer Polytechnic Institute, could prove valuable in the battle against some of the most persistent human health challenges.

Tracking down cryptic peptides
Using a newly developed method, researchers from the University of Würzburg, in cooperation with the University Hospital of Würzburg, were able to identify thousands of special peptides on the surface of cells for the first time.

Synthesis of prebiotic peptides gives clues to the origin of life on Earth
Coordination Compounds Lab of Kazan Federal University started researching prebiotic peptide synthesis in 2013 with the use of the ASIA-330 flow chemistry system.

Peptides that can be taken as a pill
Peptides represent a billion-dollar market in the pharmaceutical industry, but they can generally only be taken as injections to avoid degradation by stomach enzymes.

Harnessing psyllid peptides to fight citrus greening disease
BTI, USDA and UW scientists have identified peptides in the Asian citrus psyllid, an insect that spreads the bacterium that causes citrus greening disease (huanglongbing, HLB).

New technique has potential to protect oranges from citrus greening
Citrus greening, also called Huanglongbing (HLB), is devastating the citrus industry.

Researchers show what drives a novel, ordered assembly of alternating peptides
A team of researchers has verified that it is possible to engineer two-layered nanofibers consisting of an ordered row of alternating peptides, and has also determined what makes these peptides automatically assemble into this pattern.

Origin of life insight: peptides can form without amino acids
Peptides, one of the fundamental building blocks of life, can be formed from the primitive precursors of amino acids under conditions similar to those expected on the primordial Earth, finds a new UCL study published in Nature.

Ragon Institute study identifies viral peptides critical to natural HIV control
Investigators at the Ragon Institute of MGH, MIT and Harvard have used a novel approach to identify specific amino acids in the protein structure of HIV that appear critical to the ability of the virus to function and replicate.

Read More: Peptides News and Peptides Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.