A genetic basis for attachment disorganization in infants

October 31, 2000

Dopamine D4 receptor (DRD4) gene polymorphism is associated with attachment disorganization in infants

About 15% of one-year-old infants in non-clinical low-risk and up to 80% in high-risk (e.g. maltreated) populations show extensive disorganized attachment behavior in the moderately stressful Ainsworth Strange Situation Test. It has also been found that disorganization of early attachment is a major risk factor for the development of childhood behavior problems. The authors report an association between the DRD4 III exon 48 basepair repeat polymorphism and attachment disorganization. The 7 repeat allele was significantly more frequent in infants with disorganized attachment behavior (71%) compared to non-disorganized infants (29%). The estimated relative risk for disorganized attachment was four-fold among children carrying the 7-repeat allele. Attachment disorganization in infancy has been explained primarily by inappropriate care-giving; our finding suggests a genetic susceptibility to the collapse of organized attachment strategy under stress.
-end-
Authors: Krisztina Lakatos, I Toth, Z Nemoda, K Ney, Maria Sasvari-Szekely, J Gervai

Citation source: Molecular Psychiatry 2000 Volume 5 pages 633-637.

For further information on this work, please contact:
Dr. Krisztina Lakatos
Institute of Psychology
Hungarian Academy of Sciences
POB 398
Budapest, Hungary-1394
Tel: 36.1.239.3864
Fax: 36.1.239.6727
Email: szulakat@mtapi.hu

Molecular Psychiatry is published by the Nature Publishing Group. http://www.nature.com/mp

Editor: Julio Licinio, M.D.; phone: +1 310 206-6207; FAX: +1 310 825-6407; e-mail: licinio@ucla.eduEditorial assistant: Ms. Ava Martin; phone: +1 310 206-6739; FAX: +1 310 825-6407; e-mail: molecularpsychiatry@mednet.ucla.edu For a copy of these articles, please contact Ms. Martin.

PLEASE CITE MOLECULAR PSYCHIATRY AS THE SOURCE OF THIS MATERIAL.

Molecular Psychiatry

Related Infants Articles from Brightsurf:

Most infants are well even when moms are infected by COVID-19
Infants born to women with COVID-19 showed few adverse outcomes, according to the first report in the country of infant outcomes through eight weeks of age.

Probiotic may help treat colic in infants
Probiotics -- or 'good bacteria' -- have been used to treat infant colic with varying success.

Deaf infants' gaze behavior more advanced than that of hearing infants
Deaf infants who have been exposed to American Sign Language are better at following an adult's gaze than their hearing peers, supporting the idea that social-cognitive development is sensitive to different kinds of life experiences.

Initiating breastfeeding in vulnerable infants
The benefits of breastfeeding for both mother and child are well-recognized, including for late preterm infants (LPI).

Young infants with fever may be more likely to develop infections
Infants with a high fever may be at increased risk for infections, according to research from Penn State College of Medicine.

Early term infants less likely to breastfeed
A new, prospective study provides evidence that 'early term' infants (those born at 37-38 weeks) are less likely than full-term infants to be breastfeed within the first hour and at one month after birth.

Infants are more likely to learn when with a peer
Researchers at the University of Connecticut and University of Washington looked at the mechanisms involved in language learning among nine-month-olds, the youngest population known to be studied in relation to on-screen learning.

Allergic reactions to foods are milder in infants
Majority of infants with food-induced anaphylaxis present with hives and vomiting, suggesting there is less concern for life-threatening response to early food introduction.

Non-dairy drinks can be dangerous for infants
A brief report published in Acta Paediatrica points to the dangers of replacing breast milk or infant formula with a non-dairy drink before one year of age.

Infants can't talk, but they know how to reason
A new study reveals that preverbal infants are able to make rational deductions, showing surprise when an outcome does not occur as expected.

Read More: Infants News and Infants Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.