New studies show young African Americans at much higher risk for pre-cancerous polyps

October 31, 2005

HONOLULU, October 31, 2005 -- Two studies released at the 70th Annual Scientific Meeting of the American College of Gastroenterology show that young African Americans are at a much higher risk for colon cancer than other races. One study found that African Americans are diagnosed with colorectal cancer at a younger age than whites, while the other looked at racial differences in colonoscopy and found younger blacks are more likely to have pre-cancerous polyps that younger whites or Hispanics. These two studies highlight important colorectal cancer prevention issues and screening strategies.

Race as a Factor in Colorectal Cancer Risk

A retrospective analysis of individuals younger than age 50 who were screened for colon cancer at Nassau University Medical Center in East Meadow, NY included 177 patients. Researchers looked at racial factors in analyzing findings from colonoscopy exams and found that among those with abnormal findings, polyps were the most common among African Americans, while hemorrhoids were the most common finding for Caucasians, and Hispanics most commonly experienced diverticulosis. The prevalence of colon polyps among African Americans in this study was 48 percent, while the prevalence in other races was sharply lower: 29 percent in Caucasians and 27 percent in Hispanics. Additionally, African Americans in this study experienced a larger number of polyps proximally - or on the right side of the colon.

Researchers at Coney Island Hospital in Brooklyn, NY looked at race, age, and location of colorectal cancer in a study of 1477 patients screened for colorectal cancer between 2000 and 2004. Of the 177 patients identified with a malignancy in this study, the mean age was 67.4 years when they were diagnosed with colorectal cancer, and 41 percent were under 65. African Americans had a significantly lower age at diagnosis, 63.3 years compared to 69.7 for whites.

In this study group, African Americans demonstrated more proximal, or right-sided, cancers. "We found that one quarter of the cancers in African Americans were on the right side of the colon, making these patients more likely to present without specific symptoms, and making colonoscopy a better screening test than sigmoidoscopy," said Dr. Emmanuel Akinyemi, one of the investigators on the Coney Island study.

According to the American College of Gastroenterology, colonoscopy should be considered a "first line" screening procedure for colorectal cancer for African Americans rather than flexible sigmoidoscopy because of the high overall risk as well as some evidence that African Americans have more right-sided cancers and polyps. The right side of the colon includes the cecum, ascending colon and proximal transverse colon and cannot be reached by flexible sigmoidoscopy.

About ACG's Recommendations on Colorectal Cancer Screening in African Americans

Physician experts from the American College of Gastroenterology in March 2005 issued new recommendations to healthcare providers to begin colorectal cancer screening in African Americans at age 45 rather than 50 years. Colonoscopy is the preferred method of screening for colorectal cancer and data support the recommendation that African Americans begin screening at a younger age because of the high incidence of colorectal cancer and a greater prevalence of proximal or right-sided polyps and cancerous lesions in this population.

The recommendations were published in the March 2005 issue of the American Journal of Gastroenterology. Overall, colorectal cancer is the second leading cause of cancer deaths in the United States. African Americans are diagnosed with colorectal cancer at a younger age than whites, and African Americans with colorectal cancer have decreased survival compared with whites. The article reviews the evidence why African Americans should have their colons screened for cancer at age 45 instead of age 50, five years earlier than the current recommendations. The article was drafted by the American College of Gastroenterology's Committee on Minority Affairs and Cultural Diversity.
-end-
About the American College of Gastroenterology
The ACG was formed in 1932 to advance the scientific study and medical treatment of disorders of the gastrointestinal (GI) tract. The College promotes the highest standards in medical education and is guided by its commitment to meeting the needs of clinical gastroenterology practitioners. Consumers can get more information on GI diseases through the following ACG-sponsored programs:

  • 1-800-978-7666 (free brochures on common GI disorders, including ulcer, colon cancer, gallstones, and liver disease)
  • 1-866-IBS-RELIEF and www.ibsrelief.org (free educational materials)
  • 1-800-HRT-BURN (free brochure and video on heartburn and GERD)
  • www.acg.gi.org (ACG's Web site)

    American College of Gastroenterology

    Related Cancer Articles from Brightsurf:

    New blood cancer treatment works by selectively interfering with cancer cell signalling
    University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications.

    UCI researchers uncover cancer cell vulnerabilities; may lead to better cancer therapies
    A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.

    Breast cancer treatment costs highest among young women with metastic cancer
    In a fight for their lives, young women, age 18-44, spend double the amount of older women to survive metastatic breast cancer, according to a large statewide study by the University of North Carolina at Chapel Hill.

    Cancer mortality continues steady decline, driven by progress against lung cancer
    The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.

    Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
    Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.

    Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
    The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.

    Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
    Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.

    More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
    An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.

    New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
    Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.

    American Cancer Society outlines blueprint for cancer control in the 21st century
    The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.

    Read More: Cancer News and Cancer Current Events
  • Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.