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Understanding the fascinating interaction between bone and brain

October 31, 2016

"The best news is that the brain has become front and centre in the regulation of bone modelling", conclude authors Professors Paul Dimitri and Cliff Rosen in their concise review of the complex role of the central nervous system in bone metabolism.

The review "The Central Nevous System and Bone Metablism: An Evolving Story", published in Calcified Tissue International & Musculoskeletal Research, shows how our understanding of the control of skeletal metabolism has undergone a dynamic shift in the last two decades, primarily driven by greater understanding of energy metabolism. It also points to future directions and challenges faced by researchers as they try to better understand the complex interaction between the musculoskeletal and central nervous systems.

The authors review the latest research into the role of central regulators of bone metabolism, including leptin, neuropeptide Y (NPY), serotonin, endocannabinoids, cocaine- and amphetamine-regulated transcript (CART), adiponectin, melatonin and neuromedin U. They also discuss the role of the sympathetic and parasympathetic nervous systems in the control of skeletal metabolism, as evidence for the broader autonomic skeletal regulation. Sensory innervation of bone is also a focus, further extending our understanding of the complex neuronal regulation of bone mass.

Professor Dimitri, Professor of Child Health & Director of Research & Innovation at Sheffield Children's Hospital NHS Foundation Trust, UK stated:

"Whilst scientific advance in this field of bone metabolism has been rapid, progress is still required to understand how these model systems work in relation to the numerous and complex factors that influence skeletal metabolism, particularly in humans. Our rapidly evolving understanding of the physiological aspects of bone remodelling together with the development of more sophisticated technology will in time help us to reach this goal."
Dimitri, P. & Rosen, C. The Central Nevous System and Bone Metablism: An Evolving Story.

Calcif Tissue Int (2016). doi:10.1007/s00223-016-0179-6

About Calcified Tissue International & Musculoskeletal Research

Calcified Tissue International & Musculoskeletal Research is a peer-reviewed journal which publishes original preclinical, translational and clinical research, and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms, as well as clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signaling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.

Editors in Chief: Stuart Ralston and René Rizzoli; Musculoskeletal Research Section Editor: Roger Fielding.

Become an IOF Professional member to freely access IOF scientific journals via the IOF website:

About IOF

The International Osteoporosis Foundation (IOF) is the world's largest nongovernmental organization dedicated to the prevention, diagnosis and treatment of osteoporosis and related musculoskeletal diseases. IOF members, including committees of scientific researchers as well as 234 patient, medical and research societies in 99 locations, work together to make bone, joint and muscle health a worldwide heath care priority. / @iofbonehealth

International Osteoporosis Foundation

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