Nav: Home

Pain sensitization increases risk of persistent knee pain

October 31, 2018

Montréal, October 30, 2018 - Becoming more sensitive to pain, or pain sensitization, is an important risk factor for developing persistent knee pain in osteoarthritis (OA), according to a new study by researchers from the Université de Montréal (UdeM) School of Rehabilitation and Hôpital Maisonneuve Rosemont Research Centre (CRHMR) in collaboration with researchers at Boston University School of Medicine (BUSM). These findings have just been published in the journal Arthritis and Rheumatology.

OA is a common cause of pain and altered joint function, affecting 302 million adults worldwide. It can lead to chronic disability frequently in the knee joint. Past research suggests that a number of different factors outside of structural pathology may contribute to pain experienced in patients with OA.

"Understanding the factors that contribute to the development of persistent pain is critical in improving our ability to prevent its onset and the transition to more persistent pain', said Lisa Carlesso BSc.PT. PhD, assistant professor School of Rehabilitation UdeM and scientist CRHMR.

Researchers analyzed data from a multicenter OA study that followed 852 adults (ages 50-79) with or at risk of knee OA but who were free of persistent knee pain at the beginning of the study. Sociodemographic data, pain sensitization measurements, as well as risk factors traditionally associated with knee pain such as psychological factors, widespread pain and poor sleep were collected on the participants who then were followed for development of persistent knee pain over two years.

The researchers used the above risk factors and pain sensitization data to identify four distinct subgroups called pain susceptibility phenotypes (PSPs). The authors found these PSPs were primarily characterized by varying degrees of pain sensitization. The PSP with the highest degree of sensitization had the highest risk of developing persistent knee pain. Female gender, non-Caucasian race and age 65+ were significant sociodemographic predictors of being a member of the PSP with the highest degree of sensitization.

The researchers believe identifying these PSPs is an important step in understanding the complex pathology of knee osteoarthritis. "Our findings suggest that therapy aimed at prevention or improvement of pain sensitization may be a novel approach to preventing persistent knee pain," explained author Tuhina Neogi, MD, PhD, professor of medicine and epidemiology at BUSM and BU School of Public Health. "Preventing pain is crucial to improving quality of life and function in patients who suffer from OA."
-end-
About the study

LC was supported by a Fellowship from the Canadian Institutes for Health Research and by a collaborative scholarship from the Osteoarthritis Research Society International. TN's work is supported by US National Institutes of Health (NIH) grants P60-AR-47785, R01-AR-062506 and K24- AR-070892. The Multicenter Osteoarthritis Study is supported by NIH grants U01-AG-18820, U01- AG-18832, U01-AG-18947, and U01-AG-19079.

About the CIUSSS de l'Est-de-l'Île-de-Montréal

The Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de- Montréal (CIUSSS-Est) includes the Hôpital Maisonneuve-Rosemont, the Hôpital Santa Cabrini Ospedale, the CHSLD polonais Marie-Curie-Sklodowska and the Institut universitaire en santé mentale de Montréal, as well as the health and social services centres in Saint-Léonard, Saint-Michel, the Pointe-de-l'Île and Lucille-Teasdale. It has some 15,000 employees and close to 1,000 doctors (FTE) in 43 points of service for a population of 500,000. It offers a full range of primary health care and social services, general, specialized and super-specialized hospital care, as well as mental health care. It also offers long-term care facilities. Affiliated with Université de Montréal, the CIUSSS-Est combines the missions of teaching, evaluation and research with the training of doctors and other health professionals. Its two major research centres are recognized at the national and international levels for their expertise in mental health, immune-oncology, vision health, nephrology and cell therapy. http://www.ciusss-estmtl.gouv.qc.ca

Boston University School of Medicine

Related Osteoarthritis Articles:

Osteoarthritis can increase your risk for social isolation
In a study published in the Journal of the American Geriatrics Society, researchers examined information from the European Project on OSteoArthritis (EPOSA) study.
High rates of opioid prescriptions for osteoarthritis
Opioids work against severe pain but the risks of side effects and addiction are high.
Disease burden in osteoarthritis is similar to rheumatoid arthritis
Osteoarthritis (OA) has traditionally been viewed as a highly prevalent but milder condition when compared with rheumatoid arthritis (RA), and some may believe that it is part of a normal aging process requiring acceptance, not treatment.
3D printing may help treat osteoarthritis
In a Journal of Orthopaedic Research study, scientists used 3D printing to repair bone in the joints of mini-pigs, an advance that may help to treat osteoarthritis in humans.
Finger joint enlargements may be linked to knee osteoarthritis
Heberden's nodes (HNs) are bony enlargements of the finger joints that are readily detectable in a routine physical exam and are considered hallmarks of osteoarthritis.
Hormone therapy may be best defense against knee osteoarthritis
There is an ongoing debate regarding the relationship between knee osteoarthritis and hormone therapy (HT), with small-scale studies providing mixed results.
Going from negative to positive in the treatment of osteoarthritis
A scientific team has designed a charged molecule that improved the delivery of osteoarthritis drugs to knee joint cartilage in rodent models of the debilitating joint disorder.
Antioxidant defender protects against osteoarthritis
A protein involved in multiple cellular processes called ANP32A protects cartilage in the joints against degradation by damaging oxidation, preventing the development and progression of osteoarthritis, according to a new study by Frederique Cornelis and colleagues.
Symptoms of osteoarthritis lessened with simple changes to the diet
One gram of fish oil a day could help reduce the pain of patients with osteoarthritis, a new study in Rheumatology reports.
Get off the golf cart if you have knee osteoarthritis
It may seem intuitive that golfers with knee osteoarthritis should stay off their feet and ride in a golf cart.
More Osteoarthritis News and Osteoarthritis Current Events

Top Science Podcasts

We have hand picked the top science podcasts of 2019.
Now Playing: TED Radio Hour

Risk
Why do we revere risk-takers, even when their actions terrify us? Why are some better at taking risks than others? This hour, TED speakers explore the alluring, dangerous, and calculated sides of risk. Guests include professional rock climber Alex Honnold, economist Mariana Mazzucato, psychology researcher Kashfia Rahman, structural engineer and bridge designer Ian Firth, and risk intelligence expert Dylan Evans.
Now Playing: Science for the People

#540 Specialize? Or Generalize?
Ever been called a "jack of all trades, master of none"? The world loves to elevate specialists, people who drill deep into a single topic. Those people are great. But there's a place for generalists too, argues David Epstein. Jacks of all trades are often more successful than specialists. And he's got science to back it up. We talk with Epstein about his latest book, "Range: Why Generalists Triumph in a Specialized World".
Now Playing: Radiolab

Dolly Parton's America: Neon Moss
Today on Radiolab, we're bringing you the fourth episode of Jad's special series, Dolly Parton's America. In this episode, Jad goes back up the mountain to visit Dolly's actual Tennessee mountain home, where she tells stories about her first trips out of the holler. Back on the mountaintop, standing under the rain by the Little Pigeon River, the trip triggers memories of Jad's first visit to his father's childhood home, and opens the gateway to dizzying stories of music and migration. Support Radiolab today at Radiolab.org/donate.