Adaptive human immunity depends on the factor responsible for the formation of white blood cells

October 31, 2019

Granulocyte colony-stimulating factor (G-CSF), which causes division and differentiation of bone marrow cells depending on the body's need for leukocytes, has a significant regulatory effect not only on innate, but also on adaptive immunity. That's what scientists from the IKBFU and Research Institute of Fundamental and Clinical Immunology have found. The scientists have published an article regarding this research in Growth Factors journal.

G-CSF plays a key role in the formation of granulocytes in the bone marrow - the most numerous group of white blood cells (leukocytes). This is one of the most important immunological processes, since white blood cells form the basis of the body's anti-infection protection. G-CSF can be produced by cells of the bone marrow, blood vessels, connective tissue, as well as astrocytes that perform a structural function in the nervous system. Moreover, depending on the situation, the human body produces a different amount of G-CSF. This factor acts on stem and myeloid cells of the bone marrow, combining with special receptor proteins on their surface - CD114. This binding enhances cell growth and stimulates the transformation of cells into granulocytes, which have a high non-specific ability to capture and digest viruses and bacteria.

The authors of the study, supported by a grant from the Federal Commission of the Ministry of Education and Science, suggested that G-CSF could be an important tool for regulating the long-term adaptation of immunity to various environmental conditions. To test this, scientists took vein blood from sixteen healthy men and women aging from 21 to 40 years old. Macrophage cells responsible for the development of adaptive immune responses were isolated from their blood. The authors then studied the effect that G-CSF exerts on these cells. As a result, it was found that it exerts the most significant stimulating effect on the production of macrophages of IL-6 (interleukin-6), a cytokine involved in the adaptation of various body tissues to the environment. In addition, G-CSF decreased the number of receptors for proinflammatory cytokine interferon-gamma on macrophages and restrained the development of tissue-damaging inflammation. Based on these data, it can be assumed that G-CSF continuously regulates not only adaptive immunogenesis, but also participates in recovery processes.

Chief Scientist of the IKBFU Center for Medical Biotechnology, Viktor Seledtsov commented on the research results:

"Now G-CSF is used mainly for the treatment of leukopenia which is an insufficient amount of white blood cells. However, in the future, it can be used both for the correction of adaptive inflammatory and for the stimulation of regenerative processes in damaged tissues of the body".
-end-


Immanuel Kant Baltic Federal University

Related Bone Marrow Articles from Brightsurf:

Researchers identify the mechanism behind bone marrow failure in Fanconi anaemia
Researchers at the University of Helsinki and the Dana-Farber Cancer Institute have identified the mechanism behind bone marrow failure developing in children that suffer from Fanconi anaemia.

Nanoparticles can turn off genes in bone marrow cells
Using specialized nanoparticles, MIT engineers have developed a way to turn off specific genes in cells of the bone marrow, which play an important role in producing blood cells.

How stress affects bone marrow
Researchers from Tokyo Medical and Dental University (TMDU) identified the protein CD86 as a novel marker of infection- and inflammation-induced hematopoietic responses.

3D atlas of the bone marrow -- in single cell resolution
Stem cells located in the bone marrow generate and control the production of blood and immune cells.

Dangerous bone marrow, organ transplant complication explained
Scientists have discovered the molecular mechanism behind how the common cytomegalovirus can wreak havoc on bone marrow and organ transplant patients, according to a paper published in the journal Cell & Host Microbe.

Viagra shows promise for use in bone marrow transplants
Researchers at UC Santa Cruz have demonstrated a new, rapid method to obtain donor stem cells for bone marrow transplants using a combination of Viagra and a second drug called Plerixafor.

Bone marrow may be the missing piece of the fertility puzzle
A woman's bone marrow may determine her ability to start and sustain a pregnancy, report Yale researchers in PLOS Biology.

Cells that make bone marrow also travel to the womb to help pregnancy
Bone marrow-derived cells play a role in changes to the mouse uterus before and during pregnancy, enabling implantation of the embryo and reducing pregnancy loss, according to research published Sept.

Uncovering secrets of bone marrow cells and how they differentiate
Researchers mapped distinct bone marrow niche populations and their differentiation paths for the bone marrow factory that starts from mesenchymal stromal cells and ends with three types of cells -- fat cells, bone-making cells and cartilage-making cells.

Zebrafish help researchers explore alternatives to bone marrow donation
UC San Diego researchers discover new role for epidermal growth factor receptor in blood stem cell development, a crucial key to being able to generate them in the laboratory, and circumvent the need for bone marrow donation.

Read More: Bone Marrow News and Bone Marrow Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.