Research unveils new, reliable approach to drug delivery for cancer patients

November 01, 2005

LIVERMORE, Calif. - Prostate, breast and other cancer patients may be offered a new, stauncher targeted drug delivery system to treat their diseases in the next decade.

Using atomic force microscopy and computer simulations, researchers from the Lawrence Livermore National Laboratory and the UC Davis Cancer Center have unveiled a new and reliable technique to characterize the binding interaction of multivalent molecules designed for targeted drug delivery in cancer treatment.

The Livermore team used atomic force microscopy (AFM) to measure the binding forces between several single-chain antibody fragments and Mucin1 peptide. Mucin1 is commonly found in large quantities in a variety of epithelial cells in the human body, and one of its specific forms is a characteristic marker for prostate, breast, colon, lung, gastric and pancreatic cancers. Binding between Mucin1 and anti-bodies recognizing the marker is critical to targeted drug delivery for cancer patients.

"We found a very good way of quantifying the drug binding affinity, which determines the drug's efficiency," said Aleksandr Noy, a researcher in LLNL's Chemical Biology and Nuclear Sciences Division (CBDN), who along with CBDN postdoctoral student Todd Sulchek is the lead author of the paper that appears in the Proceedings of the National Academy of Sciences online edition for the week of Oct. 31-Nov. 4. "Not only does this technique aid doctors in delivering targeted drugs in cancer treatment, but it also may benefit the Laboratory's efforts evaluating antibodies and designing better binding molecules for biosensors that play such a critical role in national security."

Noy said the technique could be applied to other types of cancer including colon, lung, gastric and pancreatic.

The UC Davis collaborators are one of the leading groups in the radioimmunotherapeutics development field. The group has had promising outcomes from testing this new generation of enhanced radioimmunotherapeutics.

The team's results open significant new opportunities for researchers in areas ranging from drug design to biophysics.

"We developed a technique that could help to optimize binding affinity, so for this particular application we have looked at super-binders targeting cancer cells," Noy said. "If the program wants to create a super-binder for a pathogen assay, the technology and the results will be directly applicable."

In addition to Noy and Sulchek, Livermore scientists Raymond Friddle, Kevin Langry, Edmond Lau, Timothy Ratto and Michael Colvin (who now works at UC Merced) collaborated with UC Davis Cancer Center researchers Huguette Albrecht and Sally DeNardo.
-end-
Founded in 1952, Lawrence Livermore National Laboratory is a national security laboratory, with a mission to ensure national security and apply science and technology to the important issues of our time. Lawrence Livermore National Laboratory is managed by the University of California for the U.S. Department of Energy's National Nuclear Security Administration.

Laboratory news releases and photos are also available at http://www.llnl.gov/PAO and on UC Newswire.

DOE/Lawrence Livermore National Laboratory

Related Cancer Patients Articles from Brightsurf:

Higher risk of death in cancer patients with COVID-19 may be due to advanced age and more pre-existing conditions, rather than cancer itself
New research presented at this this week's ESCMID Conference on Coronavirus Diseases (ECCVID, online 23-25 September) suggests that the poor outcomes and higher death rates in cancer patients with COVID-19 could be due to them generally being older and having more underlying conditions, rather than due to the cancer itself.

The Lancet: Prostate cancer study finds molecular imaging could transform management of patients with aggressive cancer
Results from a randomised controlled trial involving 300 prostate cancer patients find that a molecular imaging technique is more accurate than conventional medical imaging and recommends the scans be introduced into routine clinical practice.

The art of cancer caregiving: How art therapies benefits those caring for cancer patients
A recent Drexel University study showed coloring and open-studio art therapy benefits stressed caregivers of cancer patients.

Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.

Cancer tissue-freezing approach may help more breast cancer patients in lower income countries
A new reusable device created by the Johns Hopkins University can help women with breast cancer in lower income countries by using carbon dioxide, a widely available and affordable gas, to power a cancer tissue-freezing probe instead of industry-standard argon.

Lots of patients with cancer, cancer survivors use but don't report complementary/alternative medicine therapies
This study used data from a nationwide survey to estimate how many patients with cancer and cancer survivors use complementary and alternative medicines (CAMS) in addition to or instead of conventional therapies, and how many don't disclose that to their physicians.

Colorectal cancer in patients with early onset is distinct from that in older patients
New research indicates that colorectal cancer diagnosed at an early age has clinical and genetic features that are different from those seen in traditional colorectal cancer diagnosed later in life.

Comparable risk of recurrent venous thromboembolism between patients with unprovoked venous thromboembolism and patients with cancer
Patients with venous thromboembolism (VTE) carry a high risk of recurrence.

Personalized cancer vaccine may increase long-term survival in patients with deadly brain cancer
An international Phase III study led by researchers at UCLA has found that a personalized GBM vaccine may increase long-term survival in some patients.

Ovarian cancer drug shows promise in pancreatic cancer patients with BRCA mutation
A targeted therapy that has shown its power in fighting ovarian cancer in women including those with BRCA1 and BRCA2 mutations may also help patients with aggressive pancreatic cancer who harbor these mutations and have few or no other treatment options.

Read More: Cancer Patients News and Cancer Patients Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.