Research connects first-time kidney stone formers and chronic kidney diseaseNovember 02, 2016
ROCHESTER, Minn. -- Mayo Clinic nephrologists have uncovered a connection between first-time kidney stone formers and chronic kidney disease. In a paper published today in Mayo Clinic Proceedings, researchers announce a persistent decline in kidney functioning following an individual's first case of kidney stones.
A Mayo Clinic team led by William Haley, M.D., and Andrew Rule, M.D., assessed a group of 384 stone formers three months after their first stone event to study the effect of kidney stones on their kidney function. Compared to the control group, kidney stone formers maintained higher levels of the blood marker cystatin C and higher levels of urine protein ? both of which are connected with higher risk of chronic kidney disease.
"Even after adjusting for other risk factors, including urine chemistries, hypertension and obesity, we still found that those with a kidney stone episode had subsequent abnormal kidney function," says Dr. Rule. "This helps us better understand the long-term implications of kidney stones beyond recovery time."
Kidney stones affect just over 7 percent of adults, and that number has been on the rise. Though previous studies have identified a long-term risk of chronic kidney disease in kidney stone formers, prior research has not assessed kidney function immediately after their first stone event.
The small, hard mineral deposits that characterize kidney stones can cause severe pain, nausea and difficulty passing urine. An increased risk of chronic kidney disease, however, could make the condition one that has a more long-term impact on an individual's health.
"This research shows that the implications of kidney stones may go beyond the discomfort they are so often associated with," says Dr. Rule. "Prevention of kidney stones may be beneficial for a person's overall kidney health."
- Felicity Enders, Ph.D., Mayo Clinic
- Lisa Vaughan, M.S., Mayo Clinic
- Ramila Mehta, M.S., Mayo Clinic
- Maxton Thoman, B.S.
- Terri Vrtiska, M.D., Mayo Clinic
- Amy Krambeck, M.D.
- John Lieske, M.D., Mayo Clinic
About Mayo Clinic Proceedings
Mayo Clinic Proceedings is a monthly peer-reviewed medical journal that publishes original articles and reviews dealing with clinical and laboratory medicine, clinical research, basic science research, and clinical epidemiology. Mayo Clinic Proceedings is sponsored by the Mayo Foundation for Medical Education and Research as part of its commitment to physician education. It publishes submissions from authors worldwide. The journal has been published for more than 80 years and has a circulation of 130,000. Articles are available at mayoclinicproceedings.org.
About Mayo Clinic
Mayo Clinic is a nonprofit organization committed to medical research and education, and providing expert, whole-person care to everyone who needs healing. For more information, visit mayoclinic.org/about-mayo-clinic or newsnetwork.mayoclinic.org.
Related Chronic Kidney Disease Articles:
A University of Delaware research team is combating chronic kidney disease (CKD) with exercise.
A Massachusetts General Hospital research team has developed a way to avoid ischemia/reperfusion injury of the kidney with a new monoclonal antibody that binds its target receptor in a way that is 'just right.'
Individuals who took proton pump inhibitors or histamine receptor-2 blockers for heartburn, acid reflux, or ulcers had elevated risks of developing kidney stones.
Allopurinol, a widely used treatment for lowering serum urate levels, does not appear to increase risk of kidney deterioration in gout patients with normal or near-normal kidney function, according to new research findings presented this week at the 2016 ACR/ARHP Annual Meeting in Washington.
Mayo Clinic nephrologists have uncovered a connection between first-time kidney stone formers and chronic kidney disease.
A team from the University of Montreal Hospital Research Centre (CRCHUM) has discovered a novel link between chronic kidney disease and diabetes.
In this issue of the JCI, researchers at the University of Montreal demonstrated that high levels of urea may compromise the function of insulin-producing pancreas cells and lead to impaired blood sugar regulation in chronic kidney disease.
Currently, there is no effective method to predict the prognosis of chronic kidney disease (CKD) patients.
Two-thirds of the children with kidney disease were classified as vitamin D deficient.
Kidney function remained unchanged among hypertensive adults in communities assigned to a public health intervention for general practitioners and community health workers, whereas kidney function significantly declined among those who received usual care.
Related Chronic Kidney Disease Reading:
The Doctor's Kidney Diets: A Nutritional Guide to Managing and Slowing the Progression of Chronic Kidney Disease
by Mandip S. Kang MD (Author)
* Winner of the IBPA Benjamin Franklin Award for Best Health title
In the United States alone, 26 million adults have chronic kidney disease (CKD), and experts project that over half the country may develop CKD due to rising rates of disorders such as diabetes. While nephrologists can monitor kidney function and treat patients with medications, they can’t always offer the nutritional guidance that every kidney patient requires. To fill this information gap, Dr. Mandip Kang has written The Doctor’s Kidney Diets, a comprehensive guide to managing,... View Details
Coping with Kidney Disease: A 12-Step Treatment Program to Help You Avoid Dialysis
by Mackenzie Walser (Author), Betsy Thorpe (Author)
A revolutionary program that can indefinitely postpone the need for dialysis
If you've been diagnosed with kidney failure, this book could save your life. If you suffer from diabetes, hypertension, obesity, or any of a host of conditions that put you at risk for kidney disease, you owe it to yourself to read what is in this book. If you are among the 60,000 North Americans who go on dialysis each year, the information in this book could substantially improve your quality of life.
In Coping with Kidney Disease, a leading expert tells you, in plain English, what you... View Details
What Is It and How Did I Get It?: Early Stage Chronic Kidney Disease
by Gail Rae (Author)
What Is It and How Did I Get It? Early Stage Chronic Kidney Disease explains to the newly diagnosed CKD patient and others the medical terms and information, and the overwhelming task of trying to understand all this at once. It covers the initial suspicion of the disease and the necessary tests to verify that suspicion. The book also tells about doctors' visits, what to expect, how to deal with them and what to do when you're missing half the information you're being given. Renal nutrition, the need for exercise, and what friends and family need to know are also included. In addition, there... View Details
Chronic Kidney Disease: For Beginners! - Learn Everything You Need To Know About Chronic Kidney Disease Detection, Prevention, Treatment And Diet! ... Disease, KIdney Stones, Kidney Disease 101)
by Adam Johnson (Author)
Chronic Kidney Disease For Beginners! - Learn Everything You Need To Know About Chronic Kidney Disease Detection, Prevention, Treatment And Diet! Do you want to know about chronic kidney infection? Chronic kidney infection is a condition that predates kidney failure. It’s not something you want to deal with, but it’s important to know the symptoms and conditions that come with this. For some, they might be minor, but others they might be severe. This book will go over everything you need to know about chronic kidney disease. By the end of this, you’ll know how to diagnose, the... View Details
Chronic Kidney Disease: The Essential Guide To CKD - Learn Everything You Need To Know About Chronic Kidney Disease (Chronic Kidney Disease, Kidney Stones, CKD)
by Susie Thompson (Author)
Chronic Kidney Disease The Essential Guide To CKD - Learn Everything You Need To Know About Chronic Kidney Disease Chronic kidney disease affects 26 million adults; it is a disease that causes measured loss of kidney function over time. The best way to deal with any disease is to learn all you can and become an active participant in your care or the care of loved ones. When you are active in your own care or the care of loved ones, treatment is more effective because you understand the condition and its effects on the body. If you are waiting for a kidney transplant, receiving... View Details
Renal Diet Cookbook for the Newly Diagnosed: The Complete Guide to Managing Kidney Disease and Avoiding Dialysis
by Susan Zogheib MHS RD LDN (Author), Jay Wish MD (Foreword)
Kick-start a kidney-healthy life with a 30-day meal plan from the author of the bestselling Renal Diet Cookbook
Figuring out what you can and cannot eat when you or someone you care for is diagnosed with stage 1-4 chronic kidney disease (CKD) is overwhelming. No one understands this more than Susan Zogheib, a registered dietitian and leader in the field of renal nutrition, who lays out an easy 30-day meal plan for a kidney-healthy diet and lifestyle. The Renal Diet Cookbook for the Newly Diagnosed is an action-based plan that equips you with weekly... View Details “Patients are tired of having doctors tell them what they can’t do and what they can’t eat. Susan Zogheib has written a patient-centered renal diet cookbook with diet plans and recipes patients will want to use, not just because they are kidney- and heart-healthy, but because they taste so good.” With all the talk of dialysis, transplants, and treatments for comorbidities, living with chronic kidney disease can be overwhelming. When it comes to your diet, it... View Details
Exercising With Chronic Kidney Disease: Solutions to an Active Lifestyle (Renal Diet HQ IQ Pre Dialysis Living) (Volume 9)
by Mrs. Mathea Ford (Author)
Struggling with an active lifestyle and dealing with kidney disease or another chronic disease? Why not get started with simple exercise activities to improve your health and your metabolism? As with any chronic illness, it is important to use physical activity to help manage you condition. Kidney disease or kidney disease diabetes is no different, your blood pressure, your heart health and your over all health can assist your body function with chronic kidney disease. Use this title to find your groove with exercising..simple tips and exercise ideas will lead you to your favorite exercise... View Details
Kidney Disease: for beginners - What You Need to Know About Chronic Kidney Disease: Diet, Treatment, Prevention, and Detection (Chronic Kidney Disease - KIdney Stones - Kidney Disease 101)
Struggling with Kidney Disease or kidney injury? If you need to understand and want to overcome your kidney problem, continue reading!
Today only, get this Amazon bestseller for just $2.99. Regularly priced at $4.99. Read on your PC, Mac, smart phone, tablet or Kindle device.
This book will help you better understand kidney disease and see how you can deal with it. It has been written as a general overview outlining the main things you need to know about this subject. It's a short read and a great start for people who know little about the subject.
Renal Diet Plan and Cookbook: The Optimal Nutrition Guide to Manage Kidney Disease
by Rockridge Press (Publisher)
―Dr. George R. Aronoff, MD, MS, FACP, Chief Medical Officer at Renal Ventures Management, LLC
Handbook of Chronic Kidney Disease Management (Lippincott Williams & Wilkins Handbook Series)
by John T. Daugirdas MD (Author)
The Handbook of Chronic Kidney Disease Management focuses on practical aspects of managing patients with mild to moderate Chronic Kidney Disease (CKD), incorporating the expertise of cardiologists, endocrinologists, general internists, and nephrologists. Chapters include case vignettes and management algorithms, and treatment recommendations reconcile recently published clinical guidelines from NKF, AHA, NCEP, and ADA. In addition, treatment recommendations in this handbook take into account the realities of reimbursements in the U.S. View Details
“Patients are tired of having doctors tell them what they can’t do and what they can’t eat. Susan Zogheib has written a patient-centered renal diet cookbook with diet plans and recipes patients will want to use, not just because they are kidney- and heart-healthy, but because they taste so good.”
With all the talk of dialysis, transplants, and treatments for comorbidities, living with chronic kidney disease can be overwhelming. When it comes to your diet, it... View Details