What does one inherit: depression or temperament?

November 04, 2002

ARTICLE: 'Dimensions of temperament as vulnerability factors in depression'

AUTHORS: Yutaka Ono, Juko Ando, Naoko Onoda, Kimio Yoshimura, Tomoo Momose, Masami Hirano, Shigenobu Kanba

Health Center, Keio University, Shinjuku-ku, Tokyo, Japan; Faculty of Letters, Keio University, Tokyo, Japan; Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan; Cancer Information and Epidemiology Division, National Cancer Center Research Institute, Tokyo, Japan; Komagino Hospital, Tokyo, Japan; Department of Psychiatry, Yamanashi Medical University, Yamanashi-ken, Japan

Based on data from a genetic analysis of dimensions of temperament and mild depression in monozygotic (MZ) and dizygotic (DZ) twins, researchers in Japan have found that depression is affected by additive genetic effects that affect dimensions of temperament; those act together with environmental experiences unique to the individual. The authors found presence of mild depression was not related directly to genetic influences. Interestingly, depression was more likely to occur in those predisposed to it by the presence of high score on harm avoidance or a high score on reward dependence (personality features from standardized scales). This means that what is inherited in depression is temperaments that predispose and lead to vulnerability to depression, the expression of which will ultimately be determined by environmental factors, and that it might be better to look for genetic markers for dimensions of temperament rather than for depression which is thought to be a heterogeneous syndrome.
Citation source: Molecular Psychiatry 2002 Volume 7, number 9, pages 948-953.

For further information on this work, please contact Dr. Yutaka Ono, Health Center, Keio University, 4-1-1 Hiyoshi, Kohoku-ku, Yokohama-shi, Kanagawa-ken, 223-8521, Japan

Telephone: 81-3-3353-1211 ext. 62453 ; FAX: 81-3-5379-0187; e-mail: yutakaon@med.keio.ac.jp

Molecular Psychiatry is published by the Nature Publishing Group. http://www.nature.com/mp

Editor: Julio Licinio, M.D.; phone: 1-310-825-7113; FAX: 1-310-206-6715; e-mail: licinio@ucla.edu

For a copy of this article, please contact Aimee Midei, editorial assistant, e-mail: molecularpsychiatry@mednet.ucla.edu.


Molecular Psychiatry

Related Depression Articles from Brightsurf:

Children with social anxiety, maternal history of depression more likely to develop depression
Although researchers have known for decades that depression runs in families, new research from Binghamton University, State University of New York, suggests that children suffering from social anxiety may be at particular risk for depression in the future.

Depression and use of marijuana among US adults
This study examined the association of depression with cannabis use among US adults and the trends for this association from 2005 to 2016.

Maternal depression increases odds of depression in offspring, study shows
Depression in mothers during and after pregnancy increased the odds of depression in offspring during adolescence and adulthood by 70%.

Targeting depression: Researchers ID symptom-specific targets for treatment of depression
For the first time, physician-scientists at Beth Israel Deaconess Medical Center have identified two clusters of depressive symptoms that responded to two distinct neuroanatomical treatment targets in patients who underwent transcranial magnetic brain stimulation (TMS) for treatment of depression.

A biological mechanism for depression
Researchers report that in depressed individuals there are increased amounts of an unmodified structural protein, called tubulin, in lipid rafts compared with non-depressed individuals.

Depression in adults who are overweight or obese
In an analysis of primary care records of 519,513 UK adults who were overweight or obese between 2000-2016 and followed up until 2019, the incidence of new cases of depression was 92 per 10,000 people per year.

Why stress doesn't always cause depression
Rats susceptible to anhedonia, a core symptom of depression, possess more serotonin neurons after being exposed to chronic stress, but the effect can be reversed through amygdala activation, according to new research in JNeurosci.

Which comes first: Smartphone dependency or depression?
New research suggests a person's reliance on his or her smartphone predicts greater loneliness and depressive symptoms, as opposed to the other way around.

Depression breakthrough
Major depressive disorder -- referred to colloquially as the 'black dog' -- has been identified as a genetic cause for 20 distinct diseases, providing vital information to help detect and manage high rates of physical illnesses in people diagnosed with depression.

CPAP provides relief from depression
Researchers have found that continuous positive airway pressure (CPAP) treatment of obstructive sleep apnea (OSA) can improve depression symptoms in patients suffering from cardiovascular diseases.

Read More: Depression News and Depression Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.