Nav: Home

Researchers propose mechanism for spread of metastatic breast cancer to bone

November 04, 2016

New Rochelle, NY, November 4, 2016--New research explains how metastatic breast cancer cells might use bone marrow-derived mesenchymal stem cells (MSCs) to help them spread to bone tissue. A study using a 3D scaffold model has shown that breast tumor-derived factors can promote the maturation of MSCs into bone cells, and that mechanical compression of the scaffold further stimulates bone development, according to an article published in Tissue Engineering, Part A, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free for download on the Tissue Engineering website until December 2, 2016.

Maureen Lynch, Claudia Fischbach, and coauthors from Cornell University (Ithaca, NY) and University of Massachusetts Amherst used a mineral-containing 3D scaffold as an in vitro model to study whether factors such as breast tumor-derived compounds and mechanical stimulation within the bone microenvironment affect the interactions between metastatic cancer cells and bone. Understanding and intervening in these interactions could have clinical implications for the nearly 75% of patients with advanced breast cancer in whom incurable skeletal metastatic disease develops.

The article entitled "Three-Dimensional Mechanical Loading Modulates the Osteogenic Response of Mesenchymal Stem Cells to Tumor-Derived Soluble Signals" describes the composition of the scaffold, the study design, and how this model can be used to evaluate the role of certain physical cues on bone metastatic breast cancer.

"The article reports a very exciting study leveraging a tissue-engineered tumor model for controlled interrogation of tumor-bone interactions with enormous implications for the development of new therapeutics" says Co-Editor-in-Chief Antonios G. Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX.
-end-
Research reported in this publication was supported by the National Cancer Institute under NIH Award NumberR01CA17303. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About the Journal

Tissue Engineering is an authoritative peer-reviewed journal published monthly online and in print in three parts: Part A, the flagship journal published 24 times per year; Part B: Reviews, published bimonthly, and Part C: Methods, published 12 times per year. Led by Co-Editors-In-Chief Antonios G. Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Complete tables of content and a sample issue may be viewed online at the Tissue Engineering website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Human Gene Therapy, and Advances in Wound Care. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

Mary Ann Liebert, Inc./Genetic Engineering News

Related Tissue Engineering Articles:

Tissue engineering advance reduces heart failure in model of heart attack
Researchers have grown heart tissue by seeding a mix of human cells onto a 1-micron-resolution scaffold made with a 3-D printer.
HKU Engineering Professor Ron Hui named a Fellow by the UK Royal Academy of Engineering
Professor Ron Hui, Chair Professor of Power Electronics and Philip Wong Wilson Wong Professor of Electrical Engineering at the University of Hong Kong, has been named a Fellow by the Royal Academy of Engineering, UK, one of the most prestigious national academies.
RIT awarded $1.8 million NIH grant to develop ultrathin membranes for tissue engineering
Researchers at Rochester Institute of Technology are advancing tissue engineering through new work in developing improved porous membranes that will be the 'scaffolds,' or foundational structures, for in vitro tissue models.
Iowa State researchers fabricate microfibers for single-cell studies, tissue engineering
Iowa State University researchers are using the science of microfluidics -- the study of fluids moving through channels just a millionth of a meter wide -- to design and fabricate microfiber scaffolds that support cell growth and tissue engineering.
Breakthrough for bone regeneration via double-cell-layered tissue engineering technique
Tokyo Medical and Dental University researchers developed a technique for attaching two distinct layers of cells on top of each other on an amnion-based scaffold.
A novel hybrid polymer simplifies 3-D printing of scaffolds for tissue engineering
A new study describes the development of a novel hybrid polymer suitable for producing 3-D-printed scaffolds on which living cells can be seeded to create engineered tissues.
Engineering adult stem cells to regenerate tissue twice as fast
Kelly Schultz, assistant professor of chemical and biomolecular engineering at Lehigh University, received a three-year NIH grant to study how cells remodel their microenvironment -- a crucial step toward engineering cells to move through synthetic material and tissue more quickly for faster wound healing and tissue regeneration.
Lasers carve the path to tissue engineering
A new technique, developed at EPFL, combines microfluidics and lasers to guide cells in 3-D space, overcoming major limitations to tissue engineering.
Challenges of custom-engineering living tissue to fix a heart
Jianyi 'Jay' Zhang, M.D., Ph.D., works to create new tissue that can replace or protect damaged muscle after a heart attack.
Clay nanotube-biopolymer composite scaffolds for tissue engineering
Scientists of Bionanotechnology Lab, Kazan Federal University, combined three biopolymers, chitosan and agarose (polysaccharides), and a protein gelatine, as the materials to produce tissue engineering scaffolds and demonstrated the enhancement of mechanical strength (doubled pick load), higher water uptake and thermal properties in chitosan-gelatine-agarose hydrogels doped with halloysite.

Related Tissue Engineering Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Anthropomorphic
Do animals grieve? Do they have language or consciousness? For a long time, scientists resisted the urge to look for human qualities in animals. This hour, TED speakers explore how that is changing. Guests include biological anthropologist Barbara King, dolphin researcher Denise Herzing, primatologist Frans de Waal, and ecologist Carl Safina.
Now Playing: Science for the People

#SB2 2019 Science Birthday Minisode: Mary Golda Ross
Our second annual Science Birthday is here, and this year we celebrate the wonderful Mary Golda Ross, born 9 August 1908. She died in 2008 at age 99, but left a lasting mark on the science of rocketry and space exploration as an early woman in engineering, and one of the first Native Americans in engineering. Join Rachelle and Bethany for this very special birthday minisode celebrating Mary and her achievements. Thanks to our Patreons who make this show possible! Read more about Mary G. Ross: Interview with Mary Ross on Lash Publications International, by Laurel Sheppard Meet Mary Golda...