Studies highlight lasting effects of early life stress on the genome, gut, and brain

November 04, 2018

SAN DIEGO -- Excessive stress during fetal development or early childhood can have long-term consequences for the brain, from increasing the likelihood of brain disorders and affecting an individual's response to stress as an adult to changing the nutrients a mother may pass on to her babies in the womb. The new research suggests novel approaches to combat the effects of such stress, such as inhibiting stress hormone production or "resetting" populations of immune cells in the brain. The findings were presented at Neuroscience 2018, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health.

Childhood stress increases the chance of developing anxiety, depression, or drug addiction later in life by two to four times, while stress during pregnancy may increase the child's risk of developing autism spectrum disorder, as well as several other psychiatric illnesses. Scientists are discovering more about the mechanisms through which childhood or fetal stress disrupts brain development and leads to these disorders, which may help reveal new therapeutic strategies.

Today's new findings show that:"The research presented today demonstrates the long-lasting and far reaching effects of stress during early development, from the populations of bacteria in the gut to the way DNA is folded in the nucleus," said press conference moderator Heather Brenhouse, PhD, of Northeastern University and an expert in the effects of early life trauma. "Understanding how stress impacts developing biological systems may lead to new, patient-specific approaches to treatment and better outcomes."
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This research was supported by national funding agencies such as the National Institutes of Health, as well as other public, private, and philanthropic organizations worldwide. Find out more about early life stress on BrainFacts.org.

Related Neuroscience 2018 Presentation: Minisymposia: Neurocognitive Development of Motivated Behavior Saturday, Nov. 3, 1:30-4 p.m., SDCC 29D

Society for Neuroscience

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