Disrupted circadian rhythms may drive anxiety and exacerbate brain disorders

November 05, 2018

SAN DIEGO -- Sleep disruptions are associated with many brain disorders, including anxiety, dementias, and traumatic brain injury. While these disruptions are sometimes viewed as a side effect of brain disorders, new findings presented today suggest that aberrant sleep-wake cycles can also drive brain pathology. The studies were presented at Neuroscience 2018, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health.

As a deeper understanding of the brain mechanisms associated with disrupted sleep and irregular circadian rhythms emerges, researchers are discovering new ways to prevent and alleviate disorders such as Alzheimer's and anxiety. The new work highlights the importance of making healthy sleep a priority.

Today's presentations reveal:"The studies presented today help deepen our understanding of why sleep is disrupted in so many patients," said press conference moderator Clifford Saper, MD, PhD, of Harvard Medical School, who's work focuses on integrated functions maintained by hypothalamus which includes the regulation of wake-sleep cycles. "They also suggest that sleep-focused therapies, such as treatments to regulate circadian rhythms, may be beneficial in the prevention or treatment of a vast array of diseases, including Alzheimer's disease and anxiety disorder and furthermore emphasize the critical need of good sleep for everyone's health."
-end-
This research was supported by national funding agencies such as the National Institutes of Health, as well as other public, private, and philanthropic organizations worldwide. Find out more about sleep on BrainFacts.org.

Related Neuroscience 2018 Presentation Symposia: Organelle Dynamics and Proteostasis in Neuronal Homeostasis and Degeneration Tuesday, Nov. 6, 1:30-4 p.m., SDCC 6A

Society for Neuroscience

Related Traumatic Brain Injury Articles from Brightsurf:

Point-of-care biomarker assay for traumatic brain injury
Intracranial abnormalities on CT scan in patients with traumatic brain injury (TBI) can be predicted by glial fibrillary acidic protein (GFAP) levels in the blood.

Long-studied protein could be a measure of traumatic brain injury
WRAIR scientists have recently demonstrated that cathepsin B, a well-studied protein important to brain development and function, can be used as biomarker, or indicator of severity, for TBI.

Reducing dangerous swelling in traumatic brain injury
After a traumatic brain injury (TBI), the most harmful damage is caused by secondary swelling of the brain compressed inside the skull.

Blue light can help heal mild traumatic brain injury
Daily exposure to blue wavelength light each morning helps to re-entrain the circadian rhythm so that people get better, more regular sleep which was translated into improvements in cognitive function, reduced daytime sleepiness and actual brain repair.

Dealing a therapeutic counterblow to traumatic brain injury
A team of NJIT biomedical engineers are developing a therapy which shows early indications it can protect neurons and stimulate the regrowth of blood vessels in damaged tissue.

Predictors of cognitive recovery following mild to severe traumatic brain injury
Researchers have shown that higher intelligence and younger age are predictors of greater cognitive recovery 2-5 years post-mild to severe traumatic brain injury (TBI).

Which car crashes cause traumatic brain injury?
Motor vehicle crashes are one of the most common causes of TBI-related emergency room visits, hospitalizations and deaths.

Traumatic brain injury and kids: New treatment guidelines issued
To help promote the highest standards of care, and improve the overall rates of survival and recovery following TBI, a panel of pediatric critical care, neurosurgery and other pediatric experts today issued the third edition of the Brain Trauma Foundation Guidelines for the Management of Pediatric Severe TBI.

Addressing sleep disorders after traumatic brain injury
Amsterdam, NL, December 10, 2018 - Disorders of sleep are some of the most common problems experienced by patients after traumatic brain injury (TBI).

Rutgers researchers discover possible cause for Alzheimer's and traumatic brain injury
Rutgers researchers discover a possible cause for Alzheimer's and traumatic brain injury, and the new mechanism may have also led to the discovery of an effective treatment.

Read More: Traumatic Brain Injury News and Traumatic Brain Injury Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.