Web-based calculator predicts risk of death, complications from diabetes and obesity

November 05, 2019

LAS VEGAS - Nov. 5, 2019 - A new web-based risk calculator can accurately predict the likelihood a patient with type 2 diabetes and obesity will die or develop serious complications including a heart attack, heart failure and diabetic kidney disease (nephropathy) within the next 10 years depending on whether they have metabolic (bariatric) surgery or continue with standard medical treatment, according to a new study* presented today by Cleveland Clinic researchers at the 36th American Society for Metabolic and Bariatric Surgery (ASMBS) Annual Meeting at ObesityWeek 2019.

Studies have shown that for most patients with obesity, metabolic surgery, which includes procedures such as sleeve gastrectomy and gastric bypass, is superior to medical therapy in improving type 2 diabetes and in lowering the risk of heart attacks, strokes and other major adverse cardiovascular events. According to a recent study in the Journal of the American Medical Association by researchers at the Cleveland Clinic, patients who had metabolic surgery were 39 percent less likely to experience a heart-, stroke-, or diabetic kidney-related complication and 41 percent were less likely to die from any cause.[1] The study compared the outcomes of 13,722 patients with type 2 diabetes and obesity (2,287 metabolic surgery patients and 11,435 closely matched patients who were eligible for surgery but received standard medical therapy).

Now these same researchers have taken this data and in a new study identified the factors that contribute to four potential adverse outcomes from diabetes -- death, cardiovascular event, heart failure and diabetic kidney disease. Using rigorous statistical analysis and machine learning, accurate prediction models were created and integrated into the new Individualized Diabetes Complication (IDC) Risk Calculator, which provides a 10-year personalized risk score if a patient continues his or her current treatment or undergoes metabolic surgery. The risk calculation is made based on a combination of variables including the patient's age, medical history, body mass index, diabetes control, and medication usage.

"The IDC Risk Calculator can provide a glimpse into the future for individuals with diabetes and obesity, and demonstrate the impact usual medical care versus metabolic surgery would have on their risk of death or major complications," said lead study author Ali Aminian, MD, FACS, FASMBS, a bariatric surgeon and associate professor of surgery at the Cleveland Clinic, OH. "This can better inform treatment decisions and doctor recommendations and hopefully lead to improved patient care and outcomes."

The IDC Risk Calculator is available in the Cleveland Clinic Risk Calculator Library and may also be downloaded as an app for Android and iOS (BariatricCalc).

According to the American Diabetes Association, 30.3 million Americans had diabetes in 2015 and 1.5 million are diagnosed with the disease every year. People with obesity are at increased risk for developing diabetes, the seventh leading cause of death in the United States.[2]

"The IDC Risk Calculator is an important evidence-based tool to help patients considering metabolic surgery understand the risks and benefits of surgical treatment and the impact it can have on their health," said Eric J. DeMaria, MD, President, ASMBS and Professor and Chief, Division of General/Bariatric Surgery, Brody School of Medicine, East Carolina University Greenville, NC, who was not involved in the study. "Greater understanding may lead to more utilization for a treatment that has been shown to improve diabetes in nearly 90 percent of patients and put it into remission in about 70 percent of people."

According to the ASMBS, about 228,000 bariatric or metabolic surgeries were performed in 2017 in the U.S., which is less than 1 percent of the population with severe obesity. Metabolic/bariatric surgery has been shown to be the most effective and long-lasting treatment for severe obesity, resulting in significant weight loss and resolution or improvements in diabetes, heart disease, sleep apnea and many other obesity related diseases.[3] The safety profile of laparoscopic bariatric surgery is comparable to some of the safest and most commonly performed surgeries in the U.S., including gallbladder surgery, appendectomy and knee replacement.[4]

The U.S. Centers for Disease Control and Prevention (CDC) reports 93.3 million or 39.8 percent of adults in the U.S. had obesity in 2015-2016.[5] The ASMBS estimates about 24 million have severe obesity, which for adults means a BMI of 35 or more with an obesity-related condition like diabetes or a BMI of 40 or more. Obesity is linked to more than 40 diseases including type 2 diabetes, hypertension, heart disease, stroke, sleep apnea, osteoarthritis and at least 13 different types of cancer.[6,7,8]
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About the ASMBS

The ASMBS is the largest organization for bariatric surgeons in the nation. It is a non-profit organization that works to advance the art and science of bariatric surgery and is committed to educating medical professionals and the lay public about bariatric surgery as an option for the treatment of severe obesity, as well as the associated risks and benefits. It encourages its members to investigate and discover new advances in bariatric surgery, while maintaining a steady exchange of experiences and ideas that may lead to improved surgical outcomes for patients with severe obesity. For more information, visit http://www.asmbs.org.

*A101

Individualized Diabetes Complications Risk Scores: Future Risk of Diabetes End-Organ Complications with and without Metabolic Surgery

Ali Aminian1, Alexander Zajichek1, David Arterburn2, Stacy Brethauer3, Steven Nissen1, Philip Schauer1, Michael Kattan1

Cleveland Clinic1 Kaiser Permanente2 Ohio State University3

[1] https://jamanetwork.com/journals/jama/article-abstract/2749478

[2] https://www.diabetes.org/resources/statistics/statistics-about-diabetes

[3] Weiner, R. A., et al. (2010). Indications and principles of metabolic surgery. U.S. National Library of Medicine. 81(4) pp.379-394. https://www.ncbi.nlm.nih.gov/pubmed/20361370

[4] Gastric Bypass is as Safe as Commonly Performed Surgeries. Health Essentials. Cleveland Clinic. Nov. 6, 2014. Accessed October 2017 https://health.clevelandclinic.org/2014/11/gastric-bypass-is-as-safe-as-commonly-performed-surgeries/

[5] https://www.cdc.gov/obesity/data/adult.html

[6] The Effectiveness and Risks of Bariatric Surgery: An Updated Systematic Review and Meta-analysis, 2003-2012. Accessed from: https://jamanetwork.com/journals/jamasurgery/fullarticle/1790378

[7] Steele CB, Thomas CC, Henley SJ, et al. Vital Signs: Trends in Incidence of Cancers Associated with Overweight and Obesity -- United States, 2005-2014. MMWR Morb Mortal Wkly Rep 2017;66:1052-1058. DOI: http://dx.doi.org/10.15585/mmwr.mm6639e1

[8] Centers for Disease Control and Prevention. (2015) The Health Effects of Overweight and Obesity. Accessed from: https://www.cdc.gov/healthyweight/effects/index.html

American Society for Metabolic and Bariatric Surgery

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