Mount Sinai researchers develop novel method to identify patterns among patients with multiple chronic conditions

November 06, 2019

A study published this month in BMJ Open by researchers at Icahn School of Medicine at Mount Sinai proposes a novel method for identifying patterns in the frequency and cost of multiple chronic conditions (MCC).

Researchers examined Medicaid claims data for 190,000 patients in the Mount Sinai Health System between 2012 and 2014. In this cohort, 61 percent of patients had MCC--the presence of two or more chronic conditions in one individual--a level far higher than in the U.S. general population (42 percent).

Using a segmented methodology, the study found that high blood pressure, high cholesterol, and diabetes were the most common triplet of chronic conditions, and women aged 50 to 65 with high blood pressure and high cholesterol were the costliest segment overall. The most surprisingly common disease pair, relative to expectations, was lung disease and heart attacks. The study found that patients living in lower-income areas developed a second chronic condition 15 years earlier, on average, than their counterparts in higher-income areas.

By shedding light on several unexpected disease clusters and their costs, this work could inform new approaches for managing chronic conditions. The research was made possible with support from Teva Pharmaceutical Industries Ltd.

"This work shows the disproportionate effects of MCC on vulnerable populations--almost two-thirds of these patients had MCC, and over half developed their second condition by age 35," said Usnish Majumdar, the study's lead author and a fourth-year medical student at the Icahn School of Medicine. "This helps us develop primary care programs with our partners to treat patients with MCC. It also provides an analytical method for health systems worldwide to track chronic condition patterns in their own settings--and design interventions to address their local needs."

Chronic conditions are the leading cause of death and disability in the United States and globally, and it is increasingly common for adults to live with more than one condition. Recognizing the growing threat of MCC, Teva and the Arnhold Institute for Global Health at Mount Sinai joined forces in 2017 to study MCC in low-resource settings. The partnership aims to understand the patient population, inform population health priorities, educate and empower patients to improve self-management, and disseminate interventions to low-resource settings around the world.

In addition to developing this analytic method, the research team at the Arnhold Institute has partnered with Teva to implement a peer-led behavior change program that helps New Yorkers with MCC track their medications, change their lifestyles, and control their conditions. The Arnhold team is also developing similar care models for patients with chronic conditions worldwide, beginning in northern Ghana.
To learn more about Mount Sinai and Teva's efforts to address MCC, visit

About the Mount Sinai Health System

The Mount Sinai Health System is New York City's largest integrated delivery system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai's vision is to produce the safest care, the highest quality, the highest satisfaction, the best access and the best value of any health system in the nation. The Health System includes approximately 7,480 primary and specialty care physicians; 11 joint-venture ambulatory surgery centers; more than 410 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and 31 affiliated community health centers. The Icahn School of Medicine is one of three medical schools that have earned distinction by multiple indicators: ranked in the top 20 by U.S. News & World Report's "Best Medical Schools", aligned with a U.S. News & World Report's "Honor Roll" Hospital, No. 12 in the nation for National Institutes of Health funding, and among the top 10 most innovative research institutions as ranked by the journal Nature in its Nature Innovation Index. This reflects a special level of excellence in education, clinical practice, and research. The Mount Sinai Hospital is ranked No. 14 on U.S. News & World Report's "Honor Roll" of top U.S. hospitals; it is one of the nation's top 20 hospitals in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Geriatrics, Gynecology, Nephrology, Neurology/Neurosurgery, and Orthopedics in the 2019-2020 "Best Hospitals" issue. Mount Sinai's Kravis Children's Hospital also is ranked nationally in five out of ten pediatric specialties by U.S. News & World Report. The New York Eye and Ear Infirmary of Mount Sinai is ranked 12th nationally for Ophthalmology, Mount Sinai St. Lukes and Mount Sinai West are ranked 23rd nationally for Nephrology and 25th for Diabetes/Endocrinology, and Mount Sinai South Nassau is ranked 35th nationally for Urology. Mount Sinai Beth Israel, Mount Sinai St. Luke's, Mount Sinai West, and Mount Sinai South Nassau are ranked regionally.

For more information, visit or find Mount Sinai on Facebook, Twitter and YouTube.

About Teva

Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) has been developing and producing medicines to improve people's lives for more than a century. We are a global leader in generic and specialty medicines with a portfolio consisting of over 35,000 products in nearly every therapeutic area. Around 200 million people around the world take a Teva medicine every day, and are served by one of the largest and most complex supply chains in the pharmaceutical industry. Along with our established presence in generics, we have significant innovative research and operations supporting our growing portfolio of specialty and biopharmaceutical products. Learn more at

The Mount Sinai Hospital / Mount Sinai School of Medicine

Related High Blood Pressure Articles from Brightsurf:

High blood pressure linked to baroreflex in rats
Researchers describe a newly observed phenomenon in the way blood pressure is maintained in certain rats.

Children who take steroids at increased risk for diabetes, high blood pressure, blood clots
Children who take oral steroids to treat asthma or autoimmune diseases have an increased risk of diabetes, high blood pressure, and blood clots, according to Rutgers researchers.

High blood pressure treatment linked to less risk for drop in blood pressure upon standing
Treatment to lower blood pressure did not increase and may decrease the risk of extreme drops in blood pressure upon standing from a sitting position.

Changes in blood pressure control over 2 decades among US adults with high blood pressure
National survey data were used to examine how blood pressure control changed overall among U.S. adults with high blood pressure between 1999-2000 and 2017-2018 and by age, race, insurance type and access to health care.

Wealthier men are more likely to develop high blood pressure
Working men with higher incomes are more likely to develop high blood pressure, reports a study presented at the 84th Annual Scientific Meeting of the Japanese Circulation Society (JCS 2020).

Regular exercise helps prevent high blood pressure, even in areas of high air pollution
Regular physical activity is a healthy way to prevent and reduce high blood pressure, even in places where pollution levels are relatively high.

Could high blood pressure at night have an effect on your brain?
Most people's blood pressure 'dips' during the night. But for some people, especially those with high blood pressure, their nighttime pressure stays the same or goes up, called 'reverse dipping.' A new study shows that these people may be more likely to have small areas in the brain that appear damaged from vascular disease and associated memory problems.

All women should be educated after childbirth about high blood pressure
After childbirth, it is not uncommon for women to experience high blood pressure.

Brain blood flow sensor discovery could aid treatments for high blood pressure & dementia
A study led by researchers at UCL has discovered the mechanism that allows the brain to monitor its own blood supply, a finding in rats which may help to find new treatments for human conditions including hypertension (high blood pressure) and dementia.

New strategy for treating high blood pressure
The key to treating blood pressure might lie in people who are 'resistant' to developing high blood pressure even when they eat high salt diets, shows new research published today in Experimental Physiology.

Read More: High Blood Pressure News and High Blood Pressure Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to