A mechanism capable of preserving muscle mass

November 06, 2019

Skeletal muscle is the most abundant tissue of the human body (about 40%) and it plays essential role in locomotion and vital functions (heart rate, breathing). During aging, in a large majority of individuals a loss of muscle mass, quality and strength occurs: this is called sarcopenia. This state, leading to disability and dependence, was declared as a disease in 2016 by the World Health Organization. By studying the young and aging muscles in mice, researchers from the Myology Research Center (Sorbonne Universite-Inserm) of the Institute of Myology identified a protein, CaVbeta1E that activates the factor GDF5. This mechanism promotes the prevention of sarcopenia by maintaining the muscle mass and strength of aged mice. The team discovered the CaVbeta1E protein in humans and showed that its expression correlated with the loss of muscle mass of the elderly. Published today in Science Translational Medicine, this study opens a new field of activity in the development of therapeutic strategies against the muscular decline associated with aging.

Sarcopenia is defined by a progressive and generalized loss of mass, strength and quality of the entire musculature from the age of 50, which may ultimately lead to a decrease of more than 30% of the initial muscle mass. Its consequences are numerous: increased risk of falls (the leading cause of death related to an injury in people over 65), increased length of hospital stay, infectious risks, dependence. Qualified as "Disease" in 2016 by the World Health Organization, sarcopenia, currently affects about one in five European over 55 year old (30 million by 2045): it is a major public health issue.

The muscle mass depends on the innervation and the excitation (nerve)-contraction (muscle) coupling. It can vary according to environmental changes, increase (hypertrophy), as after muscle training, or decrease (atrophy) as during prolonged immobilization, nerve damage, in a pathological context or during aging. The muscle's response to atrophy is the establishment of molecular mechanisms that tend to limit its loss.

As part of research for the prevention and / or treatment of sarcopenia, France Pietri-Rouxel and Sestina Falcone, team leader and researcher at the Institute of Myology, have defined the role of a protein, CaVβ1E, in the adult mouse muscle. CaVβ1E is a protein normally expressed in muscle in the embryo. After alteration of the peripheral nerve, the team observed, for the first time, the re-expression of this protein in the adult muscle. Here, it activates GDF5 to counter atrophy due to denervation. During aging, the mechanism involving the CaVbeta1E protein is impaired, thereby causing the muscle's inability to respond to its mass loss. The team tested the efficacy of CaVbeta1E or GDF5 overexpression in 78 week-old mice (the equivalent of 70 years in humans). After several weeks of treatment, the mice no longer lost muscle mass and gained strength.On the strength of these advances, the team identified the presence of CaVbeta1E protein in humans (hCaVbeta1E) and showed that a decrease of its expression is correlated with the loss of muscle mass in elderly subjects. Currently, the team is working on pre- and clinical applications that may preserve the mass, strength and quality of muscle during aging.
-end-
Publication: An embryonic CaVbeta1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.

Authors: Traore; Massire1* , Gentil Christel2* , Benedetto Chiara2, Hogrel Jean-Yves3, De la Grange Pierre4, Cadot Bruno2, Benkhelifa-Ziyyat Sofia2, Julien Laura2, Lemaitre Megane5, Ferry Arnaud2, Pietri-Rouxel France2# and Falcone Sestina2# *: co-authors; #: co-last authors.

Affiliations : 1Inovarion F-75013, Paris France ; 2Sorbonne Universite;, Centre de Recherche en Myologie, UM76 /INSERM U974 Institut de Myologie, F-75013, Paris, France ; 3Institut de Myologie, GH Pitie-Salpetriere, F-75013, Paris France; 4Genosplice, F-75005, Paris, France;5Sorbonne Universite;, INSERM, UMS28, F-75013, Paris, France

AFM-Téléthon

Related Aging Articles from Brightsurf:

Aging-US: 'From Causes of Aging to Death from COVID-19' by Mikhail V. Blagosklonny
Aging-US recently published ''From Causes of Aging to Death from COVID-19'' by Blagosklonny et al. which reported that COVID-19 is not deadly early in life, but mortality increases exponentially with age - which is the strongest predictor of mortality.

Understanding the effect of aging on the genome
EPFL scientists have measured the molecular footprint that aging leaves on various mouse and human tissues.

Muscle aging: Stronger for longer
With life expectancy increasing, age-related diseases are also on the rise, including sarcopenia, the loss of muscle mass due to aging.

Aging memories may not be 'worse, 'just 'different'
A study from the Department of Psychological & Brain Sciences in Arts & Sciences adds nuance to the idea that an aging memory is a poor one and finds a potential correlation between the way people process the boundaries of events and episodic memory.

A new biomarker for the aging brain
Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan have identified changes in the aging brain related to blood circulation.

Scientists invented an aging vaccine
A new way to prevent autoimmune diseases associated with aging like atherosclerosis, Alzheimer's disease, and Parkinson's disease was described in the article.

The first roadmap for ovarian aging
Infertility likely stems from age-related decline of the ovaries, but the molecular mechanisms that lead to this decline have been unclear.

Researchers discover new cause of cell aging
New research from the USC Viterbi School of Engineering could be key to our understanding of how the aging process works.

Deep Aging Clocks: The emergence of AI-based biomarkers of aging and longevity
The advent of deep biomarkers of aging, longevity and mortality presents a range of non-obvious applications.

Intelligence can link to health and aging
For over 100 years, scientists have sought to understand what links a person's general intelligence, health and aging.

Read More: Aging News and Aging Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.