Common Blood Pressure Drug May Promote Healthy Cells

November 06, 1998

ATHENS, Ohio -- New studies of a drug taken by millions of hypertension sufferers suggest it may have a positive side effect that could lead to healthier cells, according to researchers at Ohio University.

"Hydralazine is a very commonly used drug, and it's been used for years," said Peter Johnson, professor of biomedical sciences and chemistry at Ohio University and co-author of the study. "It's sort of reassuring that it doesn't have any negative effects on cells and that it can have positive implications."

Johnson's studies suggest that hydralazine, taken by millions of people with high blood pressure since the early 1950s, improves cell health by decreasing the number of free radicals -- chemical byproducts of normal aerobic activities that can damage a cell's membrane, proteins and DNA. These new studies contradict previous research performed in purely chemical systems that suggested hydralazine was a free-radical generator and potentially harmful to cells.

A healthy body reacts to free radicals by producing antioxidant enzymes, which neutralize the free radicals before they can harm cells. When the production of free radicals is elevated, as is the case with hypertensive patients, a cell's ability to release these protective enzymes is affected.

Hydralazine and captopril, another popular antihypertension drug, are used to lower high blood pressure by relaxing the blood vessels. Only in the past several years have researchers discovered these drugs' effects on the production of free radicals in cells.

Some drugs, such as hydralazine, were thought to increase free radicals. Others, such as captopril, are antioxidants, which researchers believed made them natural free-radical inhibitors. But Johnson's latest research, which looked at both hydralazine and captopril, suggests captopril doesn't have an immediate antioxidant effect in cells.

"Captopril did not have the kind of positive effect on the cells that we found with hydralazine. It really had no effect," Johnson said. "That was another surprise."

Johnson attributes the contradictory findings to his research method. In the past, researchers have studied the effects of these drugs in either live animals or in chemical systems in test tubes. But researchers at Ohio University studied the drugs' reactions in isolated cells from the brains and immune systems of rats.

"By studying cells, you can study the acute effect of the drug during a period of hours, and you can do very sophisticated measurements," Johnson said.

In an earlier study, Johnson looked at the effects of these two drugs and a third drug, terazosin, on live rats during a 12-week period. He found that in most cases, the medications stimulated the antioxidant enzymes that neutralize free radicals. But in a few cases, the drugs produced the opposite effect, inhibiting the body's production of these protective enzymes.

About 30 percent of U.S. adults suffer from high blood pressure and are treated with dozens of different drugs. Most antihypertension medications have a variety of mostly nonthreatening side effects that range from water retention to skin irritation.

Johnson's work was published in a recent issue of the journal Free Radical Research and was co-authored by Yanzhang Wei, a former senior scientist in the Edison Biotechnology Institute; Matthew Huentelman and Craig Peters, 1998 graduates in chemistry from Ohio University; and Alexander Boldyrev, former visiting professor of chemistry from Moscow State University. Johnson is a professor in the College of Osteopathic Medicine and holds a joint appointment in the College of Arts and Sciences.

The research was supported in part by the Russian Foundation for Fundamental Research and through a Putnam professorship awarded to Boldyrev for his stay at Ohio University.

Contact: Peter Johnson, (740) 593-1744;
Written by Melissa Rake, (740) 593-1891;

Ohio University

Related High Blood Pressure Articles from Brightsurf:

High blood pressure linked to baroreflex in rats
Researchers describe a newly observed phenomenon in the way blood pressure is maintained in certain rats.

Children who take steroids at increased risk for diabetes, high blood pressure, blood clots
Children who take oral steroids to treat asthma or autoimmune diseases have an increased risk of diabetes, high blood pressure, and blood clots, according to Rutgers researchers.

High blood pressure treatment linked to less risk for drop in blood pressure upon standing
Treatment to lower blood pressure did not increase and may decrease the risk of extreme drops in blood pressure upon standing from a sitting position.

Changes in blood pressure control over 2 decades among US adults with high blood pressure
National survey data were used to examine how blood pressure control changed overall among U.S. adults with high blood pressure between 1999-2000 and 2017-2018 and by age, race, insurance type and access to health care.

Wealthier men are more likely to develop high blood pressure
Working men with higher incomes are more likely to develop high blood pressure, reports a study presented at the 84th Annual Scientific Meeting of the Japanese Circulation Society (JCS 2020).

Regular exercise helps prevent high blood pressure, even in areas of high air pollution
Regular physical activity is a healthy way to prevent and reduce high blood pressure, even in places where pollution levels are relatively high.

Could high blood pressure at night have an effect on your brain?
Most people's blood pressure 'dips' during the night. But for some people, especially those with high blood pressure, their nighttime pressure stays the same or goes up, called 'reverse dipping.' A new study shows that these people may be more likely to have small areas in the brain that appear damaged from vascular disease and associated memory problems.

All women should be educated after childbirth about high blood pressure
After childbirth, it is not uncommon for women to experience high blood pressure.

Brain blood flow sensor discovery could aid treatments for high blood pressure & dementia
A study led by researchers at UCL has discovered the mechanism that allows the brain to monitor its own blood supply, a finding in rats which may help to find new treatments for human conditions including hypertension (high blood pressure) and dementia.

New strategy for treating high blood pressure
The key to treating blood pressure might lie in people who are 'resistant' to developing high blood pressure even when they eat high salt diets, shows new research published today in Experimental Physiology.

Read More: High Blood Pressure News and High Blood Pressure Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to