Nav: Home

Study explores timing of muscle-related problems of statin use

November 07, 2018

Statins have been linked with muscle pain and other musculoskeletal adverse events (MAEs) in some patients. A new Pharmacology Research & Perspectives study has examined the timing of MAEs that develop during statin therapy and determined whether concomitant drugs used concurrently with statin therapy shifts the timing of MAEs.

For the study, cases in which statins (atorvastatin, rosuvastatin, simvastatin, lovastatin, fluvastatin, pitavastatin, and pravastatin) were prescribed were extracted from the US Food and Drug Administration Adverse Event Reporting System Data Files.

The onset timing of statin-induced musculoskeletal adverse events (MAEs) differed with each statin. For example, the onset of MAEs was significantly faster with high-intensity statins including atorvastatin and rosuvastatin than with simvastatin. Concomitant use of drugs--even those that may increase the risk of MAEs--did not cause changes in the onset timing of MAEs associated with statins.

"Passive surveillance of adverse events has played a major role in securing drug safety as a system to detect unknown adverse events. Data mining using Food and Drug Administration Adverse Event Reporting System, which is a large-scale database, will be an aid to enhance drug safety," said senior author Dr. Daiuke Kobayashi, of Josai University, in Japan.
-end-
Peer Reviewed, Observational Study, Human

Wiley

Related Statins Articles:

Statins may not be used for protection against Parkinson's disease
Use of statins may speed up the onset of Parkinson's disease symptoms in people who are susceptible to the disease, according to Penn State College of Medicine researchers.
Statins associated with improved heart structure and function
Statins are associated with improved heart structure and function, according to research presented today at EuroCMR 2017.
Dietary supplement may carry both benefits and risks associated with statins
Red yeast rice (RYR) is contained in dietary supplements that are often used by patients with high cholesterol, and it is often proposed as an alternative therapy in those who experience side effects from statins.
Are cholesterol-lowering statins associated with reduced Alzheimer risk?
An analysis of Medicare data suggests that high use of cholesterol-lowering statins was associated with a reduced risk for Alzheimer disease but that reduction in risk varied by type of statin and race/ethnicity, findings that must be confirmed in clinical trials, according to a new article published online by JAMA Neurology.
Use of statins before cardiac arrest may aid survival afterwards
Patients who have been using cholesterol-lowering drugs known as statins fare better after a cardiac arrest than non-users.
More Statins News and Statins Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Anthropomorphic
Do animals grieve? Do they have language or consciousness? For a long time, scientists resisted the urge to look for human qualities in animals. This hour, TED speakers explore how that is changing. Guests include biological anthropologist Barbara King, dolphin researcher Denise Herzing, primatologist Frans de Waal, and ecologist Carl Safina.
Now Playing: Science for the People

#534 Bacteria are Coming for Your OJ
What makes breakfast, breakfast? Well, according to every movie and TV show we've ever seen, a big glass of orange juice is basically required. But our morning grapefruit might be in danger. Why? Citrus greening, a bacteria carried by a bug, has infected 90% of the citrus groves in Florida. It's coming for your OJ. We'll talk with University of Maryland plant virologist Anne Simon about ways to stop the citrus killer, and with science writer and journalist Maryn McKenna about why throwing antibiotics at the problem is probably not the solution. Related links: A Review of the Citrus Greening...