Nav: Home

SDHI pesticides are toxic for human cells

November 07, 2019

Mitochondria are organelles that are present in eukaryotic cells. They contain respiratory chains that are crucial for the survival of organisms. Without mitochondria, it would be impossible, in the presence of oxygen, to extract the energy contained in nutrients in order for cells to function. In human beings, the dysfunction of a key enzyme in the respiratory chain, succinate dehydrogenase (SDH), is associated with serious illnesses. Numerous pesticides used in agricultural plots or athletic fields act by blocking the SDH activity of parasitic fungi, thereby preventing their development. These compounds, which are SDH inhibitors, are known as SDHI. French scientists* have just revealed that eight SDHI pesticide molecules sold in France do not just inhibit the SDH activity of fungi, but can also block that of earthworms, bees, and human cells in varying proportions. The research team led by Pierre Rustin, Senior Researchers Emeritus at the CNRS, showed that the SDH of 22 different species is highly similar, especially in areas targeted by SDHIs. Finally, researchers demonstrated that the conditions of current regulatory tests for toxicity mask a very important effect that SDHIs have on human cells: the pesticides induce oxidative stress in cells, leading to their death. This study was published in the journal PLOS ONE on 7 November 2019.
-end-
*- Scientists from the CNRS, Inserm, Inra, Université de Paris, Université Toulouse III - Paul Sabatier, and the Assistance publique - Hôpitaux de Paris took part in this study.

CNRS

Related Mitochondria Articles:

Uncovering the presynaptic distribution and profile of mitochondria
In a recent study published in the Journal of Neuroscience, scientists from the MPFI and the University of Iowa CCOM have provided unprecedented insight into the presynaptic distribution and profile of mitochondria in the developing and mature calyx of Held.
Temple researchers identify new target regulating mitochondria during stress
Like an emergency response team that is called into action to save lives, stress response proteins in the heart are activated during a heart attack to help prevent cell death.
Runaway mitochondria cause telomere damage in cells
Targeted damage to mitochondria produces a 'Chernobyl effect' inside cells, pelting the nucleus with harmful reactive oxygen species and causing chromosomal damage.
Interplay between mitochondria and nucleus may have implications for new treatment
Mitochondria, the 'batteries' that produce our energy, interact with the cell's nucleus in subtle ways previously unseen in humans, according to research published today in the journal Science.
Dissolving protein traffic jam at the entrance of mitochondria
Researchers from Freiburg discovered a novel mechanism that ensures obstacle-free protein traffic into the powerhouse of the cell.
Miro2 is a Parkin receptor for selective removal of damaged mitochondria
Defects in mitophagy are linked to a variety of human diseases including Parkinson's and cardiac disorders.
Broken mitochondria use 'eat me' proteins to summon their executioners
When mitochondria become damaged, they avoid causing further problems by signaling cellular proteins to degrade them.
Androgen receptor, treatment target for prostate cancer, imports into mitochondria
Androgens stimulate prostate cancer cells to grow. Many drugs to target that cancer focus on stopping androgen biosynthesis or blocking the androgen receptor, or AR.
Sea slug study illuminates how mitochondria move
Defects in the transport of cells' energy organelles are a suspected cause of diseases including Alzheimer's, ALS, Huntington's and Parkinson's.
A cause of possible genetic problems in mitochondria is revealed
The loss of mitochondrial information and of mitochondria gives rise to defective cell metabolism.
More Mitochondria News and Mitochondria Current Events

Top Science Podcasts

We have hand picked the top science podcasts of 2019.
Now Playing: TED Radio Hour

Risk
Why do we revere risk-takers, even when their actions terrify us? Why are some better at taking risks than others? This hour, TED speakers explore the alluring, dangerous, and calculated sides of risk. Guests include professional rock climber Alex Honnold, economist Mariana Mazzucato, psychology researcher Kashfia Rahman, structural engineer and bridge designer Ian Firth, and risk intelligence expert Dylan Evans.
Now Playing: Science for the People

#540 Specialize? Or Generalize?
Ever been called a "jack of all trades, master of none"? The world loves to elevate specialists, people who drill deep into a single topic. Those people are great. But there's a place for generalists too, argues David Epstein. Jacks of all trades are often more successful than specialists. And he's got science to back it up. We talk with Epstein about his latest book, "Range: Why Generalists Triumph in a Specialized World".
Now Playing: Radiolab

Dolly Parton's America: Neon Moss
Today on Radiolab, we're bringing you the fourth episode of Jad's special series, Dolly Parton's America. In this episode, Jad goes back up the mountain to visit Dolly's actual Tennessee mountain home, where she tells stories about her first trips out of the holler. Back on the mountaintop, standing under the rain by the Little Pigeon River, the trip triggers memories of Jad's first visit to his father's childhood home, and opens the gateway to dizzying stories of music and migration. Support Radiolab today at Radiolab.org/donate.