Paracetamol remains treatment of choice, say GI experts

November 07, 1999

November 8, 1999 - A clear picture of the true extent of gastrointestinal (GI) complications with over-the-counter (OTC) doses of non-steroidal anti-inflammatory drugs (NSAIDs) is not yet available, according to researchers who addressed healthcare professionals and international experts at a symposium held today in Sydney, Australia.

Dr Daniel Stiel, Clinical Associate Professor, University of Sydney, Australia told delegates at the 'Clinical Consensus - An International Update on Paracetamol' symposium that Australian hospital data indicated that there were as many as 2300 serious GI complications partially attributed to prescription NSAID use each year. The vast majority of people - around 81% - had no prior warnings.

"The increasing trend toward self medication raises questions about the potential for GI complications with OTC doses of NSAIDs. There is some data emerging which suggests that GI problems at prescription doses are less evident in OTC doses but there are also some confounding factors," said Dr Stiel. "The jury is still out. In the light of current knowledge, since paracetamol continues to enjoy a favourable side effect profile, it remains a first-line analgesic for every day pain."

Dr Gurkirpal Singh, Clinical Assistant Professor of Medicine, Division of Rheumatology and Immunology, Stanford University, California, USA, presented results from the ARAMIS database (Arthritis, Rheumatism and Ageing Medical Information System) on the GI risks of OTC doses of aspirin, ibuprofen, naproxen, paracetamol and no medication from 4164 consecutively diagnosed patients with rheumatoid arthritis from eight centres in North America.

The results showed the relative risk of OTC doses of NSAIDs was "clinically significant" (ie, a three to four fold increased risk of serious GI complications) and a matter of serious concern despite being less than the previously published risk of prescription doses.

"Paracetamol was not associated with increased risk of GI complications and should be considered first line therapy," said Dr Singh.
-end-
Press contact:
Claire Powell
MediTech Media
Tel: 44-0-171-404-7151 ext 172
Fax: 44-0-171-404-6946
email: ClaireP@MediTech.co.uk

MediTech Media Ltd.

Related Arthritis Articles from Brightsurf:

Physical activity and sleep in adults with arthritis
A new study published in Arthritis Care & Research has examined patterns of 24-hour physical activity and sleep among patients with rheumatoid arthritis, lupus, and knee osteoarthritis.

Is rheumatoid arthritis two different diseases?
While disease activity improves over time for most rheumatoid arthritis (RA) patients, long-term outcomes only improve in RA patients with autoantibodies, according to a new study published this week in PLOS Medicine by Xanthe Matthijssen of Leiden University Medical Center, Netherlands, and colleagues.

Does the Mediterranean diet protect against rheumatoid arthritis?
Previous research has demonstrated a variety of health benefits associated with the Mediterranean diet, which is rich in olive oil, cereals, fruit and vegetables, fish, and a moderate amount of dairy, meat, and wine.

Reducing corticosteroid use in rheumatoid arthritis
Is the long-term use of glucocorticoids essential in people with chronic inflammatory diseases such as rheumatoid arthritis, or can early discontinuation prevent characteristic side effects?

Psoriasis onset determines if psoriatic arthritis patients develop arthritis or psoriasis first
In a new study presented at the 2019 ACR/ARP Annual Meeting, researchers found the age of psoriasis onset determines whether arthritis or psoriasis starts first in people with psoriatic arthritis.

The ACR and the Arthritis Foundation present new guidelines offering therapeutic approaches and treatment options for juvenile idiopathic arthritis
Today, the American College of Rheumatology (ACR), in partnership with the Arthritis Foundation (AF), released two guidelines on juvenile idiopathic arthritis (JIA).

Does alcohol consumption have an effect on arthritis?
Several previous studies have demonstrated that moderate alcohol consumption is linked with less severe disease and better quality of life in patients with rheumatoid arthritis, but a new Arthritis Care & Research study suggests that this might not be because drinking alcohol is beneficial.

Prospect of a new treatment for rheumatoid arthritis
An international research group led by Charité -- Universitätsmedizin Berlin has completed testing a new drug to treat rheumatoid arthritis.

Can rare lymphocytes combat rheumatoid arthritis?
Immunologists at Friedrich-Alexander-Universität Erlangen-Nürnberg have demonstrated that ILC2, a group of rare lymphoid cells, play a key role in the development of inflammatory arthritis.

Which pain medication is safest for arthritis patients?
In a recent Alimentary Pharmacology & Therapeutics study, arthritis patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) for pain plus a stomach acid-reducing medicine called esomeprazole had infrequent gastrointestinal side effects.

Read More: Arthritis News and Arthritis Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.