Ion channel inhibition limits injury-induced loss of kidney filtration

November 08, 2013

The kidney is responsible for retaining essential proteins and removing waste products from the blood stream. Injury to the kidney results in loss of kidney filter function, which if not treated promptly, can induce kidney failure.

In this issue of the Journal of Clinical Investigation, Anna Greka and colleagues at Massachusetts General Hospital determined that mice lacking the ion channel TRPC5 were protected from losing kidney filter function following kidney injury. In the absence of TRPC5, kidney podocytes did not undergo any cytoskeletal remodeling, which kept the filtration barrier in tact. Furthermore, the authors demonstrated that pharmacological inhibition of TRPC5 protects animals from protein loss in the urine following kidney injury.

This study indicates that activation of ion channel TRPC5 following kidney injury promotes loss of kidney filter function, and inhibition of this ion channel may have therapeutic potential.
-end-
TITLE: Inhibition of the TRPC5 ion channel protects the kidney filter

AUTHOR CONTACT: Anna Greka
Massachusetts General Hospital, Charlestown, MA, USA
Phone: (617) 726-9363; Fax: (617) 726-5669; E-mail: greka.anna@mgh.harvard.edu

View this article at:http://www.jci.org/articles/view/71165?key=e26e1234395ef52d73c5

JCI Journals

Related Kidney Injury Articles from Brightsurf:

Biomarker combination predicts kidney injury in critically ill children
Researchers at the University of Liverpool have identified a unique method of identifying the early signs of a potentially serious condition known as Acute Kidney Injury (AKI).

Model predicts acute kidney injury requiring dialysis in patients with COVID-19
In a recent study, a new algorithm achieved good performance for predicting which hospitalized patients will develop acute kidney injury requiring dialysis.

New algorithm predicts likelihood of acute kidney injury
In a recent study, a new algorithm outperformed the standard method for predicting which hospitalized patients will develop acute kidney injury.

Acute kidney injury among African Americans with sickle cell trait and disease
New research examines the risk of acute kidney injury in people with sickle cell trait or disease, as well as the effect of acute kidney injury on kidney function decline in these individuals.

Study reveals risk factors for acute kidney injury after brain hemorrhage
Patients who suffer an intracerebral hemorrhage (ICH) face an increased risk of acute kidney injury (AKI) during their hospitalization.

Lipids, lysosomes, and autophagy: The keys to preventing kidney injury
Lysosomes are cellular waste disposal organelles containing potent enzymes that cause cellular damage if they leak out of ruptured lysosomes.

Uncovering a 'suPAR' culprit behind kidney injury in COVID-19
A new observational study finds patients in the hospital for COVID-19 have high levels of soluble urokinase receptor (suPAR), an immune-derived pathogenic protein that is strongly predictive of kidney injury.

Patients with COVID-19 may have higher risk of kidney injury
According to Jochen Reiser, MD, PhD, the Ralph C Brown MD professor and chairperson of Rush's Department of Internal Medicine, patients with COVID-19 experience elevated levels of soluble urokinase receptor (suPAR), an immune-derived pathogenic protein that is strongly predictive of kidney injury.

SphingoTec's kidney function biomarker penKid® accurately detects acute kidney injury in infants
penKidĀ® (Proenkephalin), a unique biomarker for the real-time assessment of kidney function.

Mortality rates higher following kidney injury, University of Cincinnati research finds
New research from the University of Cincinnati shows kidney failure resulting from acute kidney injury leads to a higher risk of death in the first six months compared to kidney failure from diabetes or other causes.

Read More: Kidney Injury News and Kidney Injury Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.