Nav: Home

Particle clusters named a culprit in premature birth

November 09, 2016

A new study of more than 100 pregnant women pinpoints the abnormal buildup of mineral-protein clusters in amniotic fluid (AF) as a potential culprit in premature birth. The findings open the door to developing therapies or dietary supplements that block the formation of these particles to prevent preterm birth, a leading cause of infant death and disability. Preterm birth is often preceded by premature rupture of fetal membranes, but without an identifiable cause (such as infection or inflammation). In many pregnant women, calcified plaques can be detected in the term or preterm placenta, but their role in premature birth remains elusive. Lydia Shook and colleagues zeroed in on calciprotein particles (CPPs), mineral-protein complexes that have been previously linked to other health complications, including arthritis, atherosclerosis, and aneurism. The researchers analyzed the AF and fetal membranes from study participants who experienced spontaneous preterm birth. They detected greater levels of calcified deposits and reduced levels of a protein that inhibits calcification in individuals with premature membrane rupture compared to a control group that underwent term cesarean sections. Shook et al. discovered the AF from the preterm birth cohort formed CPP aggregates in culture and depleted a number of essential AF proteins. Furthermore, exposure to soluble CPP in vitro impaired the structure and function of fetal membrane samples from women who carried to term, pointing to the particles' toxicity. Future investigations will need to identify triggers that prematurely initiate CPP formation, the authors say.
-end-


American Association for the Advancement of Science

Related Preterm Birth Articles:

WVU biostatistician studies link between microbiome and preterm birth
Pregnant African American women are more likely than white women to give birth prematurely, but they're underrepresented in studies of preterm birth rates.
3D-printed device detects biomarkers of preterm birth
Preterm birth (PTB) -- defined as birth before the 37th week of gestation -- is the leading complication of pregnancy.
Association of quitting smoking during pregnancy, risk of preterm birth
This study of more than 25 million pregnant women reports on rates of smoking cessation at the start of and during pregnancy and also examines the association of quitting cigarette smoking and the risk of preterm birth.
Blood test developed to predict spontaneous preterm birth
Results from a multicenter study show that five circulating microparticle proteins found in first-trimester blood samples may provide important clues about risk of spontaneous preterm birth.
Scientists gain new insight on triggers for preterm birth
A group of scientists led by Ramkumar Menon at The University of Texas Medical Branch at Galveston have gained new insight on a poorly-understood key player in the timing of labor and delivery.
More Preterm Birth News and Preterm Birth Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Erasing The Stigma
Many of us either cope with mental illness or know someone who does. But we still have a hard time talking about it. This hour, TED speakers explore ways to push past — and even erase — the stigma. Guests include musician and comedian Jordan Raskopoulos, neuroscientist and psychiatrist Thomas Insel, psychiatrist Dixon Chibanda, anxiety and depression researcher Olivia Remes, and entrepreneur Sangu Delle.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...