New cancer drugs saved over 1.2 million people in the US over 16 years, new study shows

November 09, 2020

More than 1.2 million people in the US prevented facing death following a cancer diagnosis, between the year 2000 and 2016, thanks to ever improving treatment options - a large new national study shows.

Published in the peer-reviewed , the new findings highlight how new drugs commissioned during this period to target the 15 most common cancer types helped to reduce mortality by 24% per 100,000 people in the States.

The study, carried out by experts at PRECISIONheor and Pfizer, also show that 106 new treatments were approved across these 15 most common tumours - including colorectal cancer, lung cancer, breast cancer, non-Hodgkin's lymphoma, leukemia, melanoma, gastric cancer, and renal cancer.

These new cancer drug approvals were associated with significant decreases in deaths - as measured by treatment stocks. In 2016 alone, the team estimate that new treatments were associated with 156,749 fewer cancer deaths for the 15 most common tumor types.

Across the 16 years this mortality figure was down by 1,291,769, whilst the following cancers were also reduced significantly:
  • Breast cancer - 127,874
  • Colorectal - 46,705
  • Lung - 375,256
  • Prostate - 476,210
  • Non-Hodgkin lymphoma -48,836

Delivering the good news, lead author Dr Joanna MacEwan, from PRECISIONheor, says: "These findings can help contribute to a better understanding of whether increased spending on cancer drugs are worth the investment. While we do not answer this question directly, our results demonstrate that the result of successful investment--i.e., new cancer therapy approvals--generates significant benefits to patients.

"The efficacy of each treatment is estimated from clinical trial results, but this study provides evidence that the gains in survival measured in clinical trials are translating into health benefits for patients in the real world and confirms previous research that has also shown that new pharmaceutical treatments are associated with improved survival outcomes for patients."

Whilst mortality rates were down across many cancers, estimated deaths were up by 825 in people with thyroid cancer, and 7,768 for those with bladder cancer. The study explains these rises are likely due to the result of sparse drug approvals during this period: five for thyroid cancer and three for bladder cancer.

Co-author Rebecca Kee states more can still be done.

"There were no approvals in liver or uterine cancer from 2000 to 2016, and few approvals in pancreatic and oral cancer. Seven in 10 of the drug approvals came after 2008, in the latter half of the study time period. Thus, we haven't yet observed the full effect of their introductions in terms of reduced mortality," she added.

The study - funded by Pfizer - used a series of national data sets from sources including the Centers for Disease Control and Prevention, the US Mortality Files by the National Center of Health Statistics, Survival, Epidemiology and End Results program (SEER), and United States Cancer Statistics data.

The team calculated age-adjusted cancer mortality rates per year by the 15 most common tumor types.

They also looked at incident cases of cancer by tumor type - represented as per 100,000 population for all ages, races, and genders.

They then translated the change in cancer mortality in the USA from 2000 to 2016 associated with treatment stocks in each year into deaths averted per year from 2000 to 2016.

The treatment stock for each year was calculated as the weighted sum of new indication approvals since 1976 (which is a standard measure in this field of research).

The findings highlight how drugs prescribed are having a huge effect; with the mortality changes largest in prevalent tumor types with relatively more drug approvals: lung cancer, breast cancer, melanoma, lymphoma and leukemia.

"When interpreting these results, however, one must carefully evaluate whether there are alternative explanations for observed mortality reductions that may be correlated over time with new treatments," Dr MacEwan says.

Therefore, in order to control external factors - such as smoking rates, age distribution of the population, and cancer screening practices - and differentiate them from the impact of drug approvals, the team controlled for tumor-specific cancer incidence, driven by these underlying population level trends.

"Improved screening could partially explain the decline in mortality in some tumor types," Dr MacEwan explained, however.

"For instance, uptake of screening programs for breast, cervical, and colorectal cancer remained relatively high at >50% in 2015, all of which have been associated with mortality declines."

The overall figures uncovered likely understate the impact of new drugs approved between 2000 and 2016, the study suggests. This is because many drugs were approved later during the study period, meaning the bulk of mortality reductions are likely to be realized after the end of the study period.

Other limitations of the study include that new treatment interventions were limited to cancer pharmaceutical interventions and did not account for non-pharmaceutical innovations, such as robotic surgery, advances in radiotherapy and other surgical techniques, which may also affect cancer mortality.

The authors now call for future research to evaluate the relationship between drug approvals and cancer mortality post 2016.
-end-


Taylor & Francis Group

Related Robotic Surgery Articles from Brightsurf:

Decision conflict before cancer surgery correlates with lower activity after surgery
Nearly one-third of cancer patients who decide to undergo surgery for their condition may have second thoughts, and this decision conflict may lead to less favorable treatment outcomes in both the near- and long-term, according to a team of investigators at Massachusetts General Hospital and Ariadne Labs.

Robotic surgery in the COVID-19 era: Urologists take on the challenges
Robotic surgery plays a major role in modern management of prostate cancer, bladder cancer, and other conditions treated by urologists.

Robotic surgery may improve outcomes in mouth and throat cancer
Robotic surgery for patients with early stage, oropharyngeal squamous cell cancer is associated with improved health outcomes, including better long-term survival, according to a Cedars-Sinai study published Thursday in JAMA Oncology.

Examining association between weight loss before bariatric surgery, risk of death after surgery
Researchers looked at whether a patient's body weight and weight loss before bariatric surgery were associated with risk of death within 30 days after surgery using data from nearly 500,000 patients in the US and Canada.

Most deaths related to noncardiac surgery occur after surgery and after discharge from hospital
It's not the operating room that is risky for patients undergoing noncardiac surgery; it's the recovery period.

Robotic surgery for throat cancer not superior to radiation therapy, study finds
In 2012, scientists at Lawson Health Research Institute launched the world's first clinical trial comparing robotic surgery to radiation therapy for the treatment of oropharyngeal cancer (cancer at the back of the throat).

Children requiring thyroid surgery have better outcomes at high-volume surgery centers
New research recently published in the Journal of Pediatric Surgery found that post-operative success rates of pediatric thyroid patients, particularly children who require a thyroidectomy, correlate with the institution's patient volume.

Do negative public attitudes toward weight loss surgery stop some patients from having surgery?
Most patients who qualify for weight loss surgery don't have the procedure despite its safety and effectiveness.

Decoding robotic surgery skills
Researchers from the Keck School of Medicine of USC are looking to technology to help deconstruct expert surgeons' robotic surgery skills so they can create an objective, standardized way to train the next generation of surgeons.

Robotic surgery as effective as open surgery for bladder cancer
Robotic surgery is as effective as traditional open surgery in treating bladder cancer, according to a landmark study published in the journal Lancet.

Read More: Robotic Surgery News and Robotic Surgery Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.