PFOA exposure in utero linked to child adiposity and faster BMI gain

November 11, 2015

PROVIDENCE, R.I. [Brown University] -- Children whose mothers were exposed to relatively high levels of the chemical PFOA during pregnancy experienced more rapid body fat gain and higher body fat by age 8 than children whose mothers were less exposed, according to a new analysis in the journal Obesity.

PFOA -- perfluorooctanoic acid -- is a suspected "obesogen," because lab studies suggest exposure to its broader family of PFAS chemicals may alter the body's metabolism and fat cell development.

This study of 204 Cincinnati mothers and their children looked at potential childhood effects of PFOA, an industrial chemical used in the manufacture oil/water repellant textiles, firefighting foam, and nonstick coatings. The substance was used for years at a chemical plant upstream of the city along the Ohio River in West Virginia.

The new analysis derives from the HOME study (Health Outcomes and Measures of the Environment), a cohort of 389 mothers and their children in Cincinnati who have been followed since pregnancy. The HOME study found that the average exposure measured among the mothers in the cohort was more than twice that of a representative sample of pregnant women from the United States.

The researchers, led by Joseph Braun, assistant professor of epidemiology at Brown University, found that relatively high exposure had a statistically significant association with the amount and pace of body fat gain in children during the first eight years of life. The mothers and children in the new study were classified into three subgroups, or terciles, based on the mother's exposure level during pregnancy.

"The increase in body fat we observed among children born to women in the second and third PFOA terciles was equivalent to a 0.4 to 1.1 kilogram (0.9 to 2.4 pounds) increase in body fat for a child of average weight in the cohort at 8 years of age," the scientists wrote.

While the extra adipose correlated with PFOA exposure may seem subtle, Braun said, it's still enough to be a significant public health concern. Excess body fat may increase the risk of type 2 diabetes later in life.

"There isn't a threshold at which we say you shouldn't add more fat mass -- any more fat mass is bad fat mass," Braun said. "When you look at the risk of diabetes in adults, the risk is pretty much linear across the whole range of BMI."

Given its observational nature, the study only shows an association between prenatal PFOA levels and childhood adiposity. It does not prove that the exposure caused the effect. More research is required, Braun said.

Parsing PFOA

Overall studies of PFOA and weight gain have been mixed, the researchers acknowledged. In this study, children were not only weighed and measured to calculate BMI, but also their quantity of fat tissue, or adiposity, was measured. Braun said this makes the study data possibly more reliable than a larger prior study, done closer to the West Virginia plant, that relied on self-reports of weight. That study found no effect.

Also the new study is rare in that reports the BMI gain of children over a long period of time. The researchers found that children born to women with higher levels of PFOA in their blood during pregnancy gain BMI more rapidly between 2 and 8 years of age. Children in the highest PFOA tercile had the lowest BMI at age 2, but by age 8 they had a BMI similar to the children in the first tercile.

The finding that children of more highly exposed mothers start smaller and then gain weight faster could explain why studies that look at only one moment in time might find an association with PFOA and higher fat, while another study that looked at an earlier time might find the opposite.

In the analysis, Braun and his colleagues statistically controlled for a wide variety of potentially confounding factors, including the mothers' education, income, race, BMI, diet, smoking, and exposure to other potential obesogens like bisphenol A and phthalates. But the study did not account for the diets of the children or for water intake of either mothers or children. Water intake is one of the presumed means of PFOA exposure and is something Braun hopes to measure in the future.

The study raises concerns about potential effects of PFOA exposure that should be pursued further, Braun said.

"I think it's significant enough to warrant additional investigation to see if the trends continue as these children get older," Braun said, "and to see if other markers of either fetal growth or rapid early infancy growth are associated with these exposures."
The paper's other authors are Aimin Chen of the University of Cincinnati; Antonia Calafat of the Centers for Disease Control and Prevention; Kimberly Yolton of Cincinnati Children's Hospital Medical Center; and Glenys Webster and Bruce Lanphear of Simon Fraser University.

The National Institute of Environmental Health and Safety supported the research (grants: R01ES020346, PO1ES11261, R01ES014575, R01ES020349).

Brown University

Related Pregnancy Articles from Brightsurf:

COVID-19 has a prolonged effect for many during pregnancy
Symptoms for pregnant women with COVID-19 can be prolonged, lasting two months or longer for a quarter of the women who participated in a national study led by UC San Francisco and UCLA.

Relaxed through pregnancy
A group of researchers from Charité - Universitätsmedizin Berlin have been able to show that maternal psychological wellbeing during pregnancy has a positive effect on newborn infants.

Trajectories of antidepressant medication use during pregnancy
In an analysis of women who started pregnancy when taking antidepressant medications, investigators identified three trajectories of antidepressant dispensing during pregnancy: more than half stopped their treatment, a quarter maintained their treatment throughout pregnancy, and one-fifth discontinued it for a minimum of three months and then resumed it during the postpartum period.

Are women using e-cigarettes during preconception and/or pregnancy?
A new study of 1,365 racially/ethnically diverse, low-income pregnant women found that 4% reported e-cigarette use.

A better pregnancy test for whales
To determine whale pregnancy, researchers have relied on visual cues or hormone tests of blubber collected via darts, but the results were often inconclusive.

Cannabis use during pregnancy
The large health care system Kaiser Permanente Northern California provides universal screening for prenatal cannabis use in women during pregnancy by self-report and urine toxicology testing.

Questions and answers about cannabis use during pregnancy
A new study shows that women have many medical questions about the use of cannabis both before and during pregnancy, and during the postpartum period while breastfeeding.

The effect of taking antidepressants during pregnancy
Exposure to antidepressants during pregnancy and the first weeks of life can alter sensory processing well into adulthood, according to research in mice recently published in eNeuro.

Is ivermectin safe during pregnancy?
Is it safe to give ivermectin to pregnant women? To answer this question, researchers from the Barcelona Institute for Global Health (ISGlobal), an institution supported by 'la Caixa,' conducted a systematic review and meta-analysis of studies that reported cases of accidental exposure to the drug among pregnant women.

Going to sleep on your back in late pregnancy
This study looked at whether going to sleep on your back in the third trimester of pregnancy was associated with average lower birth weights.

Read More: Pregnancy News and Pregnancy Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to