CCNY researchers open 'Golden Window' in deep brain imaging

November 11, 2015

The neuroscience community is saluting the creation of a "Golden Window" for deep brain imaging by researchers at The City College of New York led by biomedical engineer Lingyan Shi. This is a first for brain imaging, said Shi, a research associate in City College's Institute for Ultrafast Spectroscopy and Lasers, and the biology department.

The breakthrough holds promise for the noninvasive study of the brain and breasts in greater detail than possible today.

Working with Distinguished Professor of Physics Robert R. Alfano and Adrian Rodriguez-Contreras, an assistant professor of biology, Shi's team proved theoretically and experimentally that deep imaging of the brain is possible using light at wavelength 1600-1880nm (nanometer). This is dubbed the "Golden Window" for imaging.

In the past, near-infrared (NIR) radiation has been employed using one and two-photon fluorescence imaging at wavelengths 650-950 nm for deep brain imaging. This is known as optical window 1.

Shi, who earned a Ph.D. in biomedical engineering from CCNY's Grove School of Engineering in 2014, said the current research introduces three new optical windows in the NIR region. And she demonstrates the windows' potential for deeper brain tissue imaging due to the reduction of scattering that causes blurring. Published by the Journal of Biophotonics, her study sheds light on the development of next generation of microscopy imaging technique, in which the "Golden Window" may be utilized for high resolution deeper brain imaging.

The next step in the research is in vivo imaging in mice using Golden Window wavelength light.
-end-


City College of New York

Related Brain Articles from Brightsurf:

Glioblastoma nanomedicine crosses into brain in mice, eradicates recurring brain cancer
A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research from the University of Michigan shows.

Children with asymptomatic brain bleeds as newborns show normal brain development at age 2
A study by UNC researchers finds that neurodevelopmental scores and gray matter volumes at age two years did not differ between children who had MRI-confirmed asymptomatic subdural hemorrhages when they were neonates, compared to children with no history of subdural hemorrhage.

New model of human brain 'conversations' could inform research on brain disease, cognition
A team of Indiana University neuroscientists has built a new model of human brain networks that sheds light on how the brain functions.

Human brain size gene triggers bigger brain in monkeys
Dresden and Japanese researchers show that a human-specific gene causes a larger neocortex in the common marmoset, a non-human primate.

Unique insight into development of the human brain: Model of the early embryonic brain
Stem cell researchers from the University of Copenhagen have designed a model of an early embryonic brain.

An optical brain-to-brain interface supports information exchange for locomotion control
Chinese researchers established an optical BtBI that supports rapid information transmission for precise locomotion control, thus providing a proof-of-principle demonstration of fast BtBI for real-time behavioral control.

Transplanting human nerve cells into a mouse brain reveals how they wire into brain circuits
A team of researchers led by Pierre Vanderhaeghen and Vincent Bonin (VIB-KU Leuven, Université libre de Bruxelles and NERF) showed how human nerve cells can develop at their own pace, and form highly precise connections with the surrounding mouse brain cells.

Brain scans reveal how the human brain compensates when one hemisphere is removed
Researchers studying six adults who had one of their brain hemispheres removed during childhood to reduce epileptic seizures found that the remaining half of the brain formed unusually strong connections between different functional brain networks, which potentially help the body to function as if the brain were intact.

Alcohol byproduct contributes to brain chemistry changes in specific brain regions
Study of mouse models provides clear implications for new targets to treat alcohol use disorder and fetal alcohol syndrome.

Scientists predict the areas of the brain to stimulate transitions between different brain states
Using a computer model of the brain, Gustavo Deco, director of the Center for Brain and Cognition, and Josephine Cruzat, a member of his team, together with a group of international collaborators, have developed an innovative method published in Proceedings of the National Academy of Sciences on Sept.

Read More: Brain News and Brain Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.