Smog aggravates asthma in children born prematurely or of low birthweight, UC Berkeley researchers find

November 12, 2000

Smog-induced asthma symptoms are more severe in children born prematurely or of low birthweight, according to a study of 846 inner-city children conducted by researchers at the University of California, Berkeley.

"The lower the birthweight and the more premature the child was as an infant, the greater the effect of pollution in triggering asthma attacks," said Kathleen Mortimer, a UC Berkeley School of Public Health epidemiologist and lead author of the study, which appears today (Thursday, Nov. 16) in the American Journal of Respiratory and Critical Care Medicine.

While researchers have known that asthmatics often suffer more wheezing and shortness of breath on days when air pollution levels soar, they have been puzzled to see that the severity of symptoms varies greatly from patient to patient. Mortimer and UC Berkeley professor of epidemiology Ira Tager, working with colleagues at Harvard Medical School and Case Western Reserve University, went looking for reasons why some children might have more severe reaction to air pollution than others.

The team found that asthmatic children born more than three weeks prematurely or weighing less than 5.5 pounds had a six-fold decrease in breathing capacity on smoggy days as compared to full-weight, full-term children. The children also reported a five-fold greater incidence of symptoms like wheezing, coughing and tightness in the chest.

Previous studies have found that low birthweight and premature birth are risk factors for asthma, but this study is the first to show that air pollution aggravates asthma more severely in such children.

"It is a piece of evidence that has to be taken seriously," said Tager. "This study demonstrates the short-term adverse consequences of air pollution at relatively low levels."

Indeed, it did not take a large jump in air pollution to provoke asthma symptoms in the children. Less than five percent of the days in the study, which spanned from the beginning of June to the end of August, had air pollution levels that exceeded federal standards.

"Our results raise the question of whether the federal standards are sufficient to protect sensitive subgroups like children born prematurely," said Mortimer. The study could help regulators establish air quality standards targeted towards sensitive subgroups, rather than blanket standards.

Approximately five million, or seven percent, of children under age 17 suffer from asthma nationally. Increased asthma symptoms translate to more missed school days, more physician visits and more hospitalizations, all of which can have significant financial impacts.

The study was part of a larger, multi-center study of inner-city children aged four to nine who suffer from asthma. The children lived in neighborhoods where at least 30 percent of resident had incomes below the U.S. poverty line, and that were located in eight urban areas across the nation: The Bronx and East Harlem, N.Y.; Baltimore, Md.; Washington, D.C.; Detroit, Mich.; Cleveland, Ohio; Chicago, Ill.; and St. Louis, Mo.

Because all the children were from low-income neighborhoods, the study could not examine whether socioeconomic status influenced the children's response to air pollution. "There is no reason to think this wouldn't hold up for all socioeconomic classes," said Tager, "but a study to confirm that should be done."

During the study, Mortimer and her colleagues asked children to keep daily records of symptoms such as wheezing, coughing and tightness in the chest. Each child also measured his or her peak exhalation flow rate by breathing into a measuring device each morning and evening. The researchers interviewed parents to determine which children were born prematurely or of low birthweight.

The researchers compared the asthmatic symptoms to the average air quality data gathered in each city by the U.S. Environmental Protection Agency. Of the four pollutants measured by EPA (sulfur dioxides, nitrogen dioxide, ozone and particulate matter of less than 10 micrometers in size or PM10), only ozone measurements were available for all days in all eight urban areas, so ozone levels were used as a marker for summer air pollution. Ozone levels were stratified into 15 ppm increments and averaged over five-day periods.

Only morning symptoms were elevated during smoggy periods. Symptoms that occur in the morning may be a more sensitive indicator of a child's response to air pollution, said Mortimer, because the children had not taken any asthma medication yet or engaged in any strenuous activity that might have exaggerated the effect.

The study did not see any evidence that exposure to environmental tobacco smoke influenced how the children responded to outdoor air pollution. Mortimer said this might be explained by the fact that the study was done during the summer, a time when children generally spend less time indoors. "In the winter, we might see a stronger effect from indoor sources," she said.

Mortimer and Tager recently launched a study in Fresno, Calif. to document the effects of air pollution on 450 asthmatic children over a period of four years and to see whether their sensitivity to smog changes as the children grow older.
-end-
Contact: Catherine Zandonella
510-643-7741
clz@pa.urel.berkeley.edu

NOTE: Dr. Kathleen Mortimer can be reached at 510-642-6861 or at . From Nov. 15-17, she can be reached via cell phone at 510-717-3830.

Dr. Ira Tager can be reached at 510-642-3997.

University of California - Berkeley

Related Asthma Articles from Brightsurf:

Breastfeeding and risks of allergies and asthma
In an Acta Paediatrica study, exclusive breastfeeding for the first 3 months was linked with a lower risk of respiratory allergies and asthma when children reached 6 years of age.

Researchers make asthma breakthrough
Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma.

Physics vs. asthma
A research team from the MIPT Center for Molecular Mechanisms of Aging and Age-Related Diseases has collaborated with colleagues from the U.S., Canada, France, and Germany to determine the spatial structure of the CysLT1 receptor.

New knowledge on the development of asthma
Researchers at Karolinska Institutet in Sweden have studied which genes are expressed in overactive immune cells in mice with asthma-like inflammation of the airways.

Eating fish may help prevent asthma
A scientist from James Cook University in Australia says an innovative study has revealed new evidence that eating fish can help prevent asthma.

Academic performance of urban children with asthma worse than peers without asthma
A new study published in Annals of Allergy, Asthma and Immunology shows urban children with poorly controlled asthma, particularly those who are ethnic minorities, also suffer academically.

Asthma Controller Step Down Yardstick -- treatment guidance for when asthma improves
The focus for asthma treatment is often stepping up treatment, but clinicians need to know how to step down therapy when symptoms improve.

Asthma management tools improve asthma control and reduce hospital visits
A set of comprehensive asthma management tools helps decrease asthma-related visits to the emergency department, urgent care or hospital and improves patients' asthma control.

Asthma linked to infertility but not among women taking regular asthma preventers
Women with asthma who only use short-acting asthma relievers take longer to become pregnant than other women, according to research published in the European Respiratory Journal.

What are the best ways to diagnose and manage asthma?
A team of experts from The University of Texas Medical Branch at Galveston examined the current information available from many different sources on diagnosing and managing mild to moderate asthma in adults and summarized them.

Read More: Asthma News and Asthma Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.