Cholesterol and heart disease

November 12, 2001

The Framingham algorithm, which helps clinicians calculate cholesterol targets for people with different cardiac risk factors, may be inadequate for determining a person's risk of coronary artery disease (CAD).

Jean-Pierre Després and coauthors have reviewed how individuals with a normal low-density lipoprotein (LDL) cholesterol level can still be at increased risk of CAD, particularly if they carry additional risk factors such as central obesity, elevated serum triglyceride levels and insulin resistance. In such people, a better marker for increased CAD risk may be an elevated total cholesterol:high-density lipoprotein cholesterol ratio. Thus, even if such a person's LDL cholesterol level is considered acceptable, the authors recommend targeting the causal factors of this atherogenic dyslipidemia, including abdominal obesity.
-end-
p. 1331 Evaluation and management of atherogenic dyslipidemia: beyond low-density lipoprotein cholesterol -- J.-P. Després et al

Canadian Medical Association Journal

Related Insulin Resistance Articles from Brightsurf:

Researchers find molecular link between liver disease, insulin resistance
Yale researchers have zeroed in on a molecular link between nonalcoholic fatty liver disease and liver insulin resistance in type 2 diabetes.

A gatekeeper against insulin resistance in the brain
The brain plays a major role in controlling our blood glucose levels.

Gene in fat plays key role in insulin resistance
DALLAS - July 23, 2020 - Deleting a key gene in mice in just their fat made tissues throughout these animals insulin resistant, in addition to other effects, a new study by UT Southwestern researchers shows.

Does insulin resistance cause fibromyalgia?
Researchers led by a team from The University of Texas Medical Branch at Galveston were able to dramatically reduce the pain of fibromyalgia patients with medication that targeted insulin resistance.

New insight into how obesity, insulin resistance can impair cognition
Obesity can break down our protective blood brain barrier resulting in problems with learning and memory, scientists report.

Insulin resistance under-diagnosed in non-diabetics with Parkinson's disease
Almost two-thirds of non-diabetic patients with Parkinson's disease (PD) may be insulin resistant, despite having normal blood sugar, report scientists in the Journal of Parkinson's Disease.

Light exposure during sleep may increase insulin resistance
According to preliminary results from a new study, nighttime light exposure during sleep may affect metabolic function.

Exosomes are the missing link to insulin resistance in diabetes
Chronic tissue inflammation resulting from obesity is an underlying cause of insulin resistance and type 2 diabetes.

Heart hormones protect against obesity and insulin resistance
By fleshing out how one signaling receptor contributes to causing obesity through its activity in fatty tissue but not in muscle cells, SBP scientists have zeroed in on an important new avenue of exploration for combating metabolic disease.

Connecting the dots between insulin resistance, unhealthy blood vessels and cancer
This research highlights biological mechanisms driven by insulin resistance that impair blood vessel health and may be shared by both cancer and cardiovascular disease.

Read More: Insulin Resistance News and Insulin Resistance Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.