News tips for Wednesday, Nov. 12, 2003

November 12, 2003

To complement our news releases, here are additional news tips reported by the American Heart Association's News Media Relations from more than 3,700 abstracts. Note: Stories are embargoed until papers are presented or poster sessions begin. Presentation times are indicated with each entry; however, all embargoes will lift by 4 p.m. EDT each day.

8:30 a.m. - Abstract #3051 (poster) - Cardiac "regeneration" therapy boosts blood flow in ischemia. Japanese researchers report they've been able to improve blood flow to the diseased heart muscle of a small group of patients with blood vessel blockages that cause chest pain (intractable ischemia) using granulocyte colony-stimulating factor (G-CSF). Half of the 22 patients in the study received subcutaneous injections of G-CSF, which earlier experiments have shown can mobilize cardiac muscle and blood vessel "progenitor" cells from bone marrow to stimulate tissue growth. The other 11 patients were controls. SPECT scans performed before and a month after experimental treatment with G-CSF showed "significantly decreased" extent and severity of ischemia in the treated group but no change in the controls. Neither patient group had clotting or other serious complications, nor no significant changes were seen in either group's left ventricular function. G-CSF improved heart blood flow in intractable ischemic heart disease and there was an increase of CD34 positive cell (a marker of endothelial progenitor cells) in the peripheral supple of blood, the scientists reported.

8:45 a.m. - Abstract #2909 - In diabetic women, bypass surgery no better than angioplasty. Previous reports have indicated that long-term survival in diabetics with multi-vessel coronary disease is notably better in those treated with bypass surgery compared to balloon angioplasty. Surprisingly, this supposed advantage does not appear to hold for diabetic women. Researchers studied data on 280 female and 362 male diabetic patients in the Bypass Angioplasty Revascularization Investigation (BARI). Survival after 10 years was lower in diabetic men treated with angioplasty than diabetic men treated with bypass (49 percent vs. 67 percent). But in diabetic women, survival rates were nearly equal for angioplasty (53 percent) and bypass surgery (51 percent). Men's bypass survival advantage appeared limited to those getting an internal mammary artery graft, but use of this conduit didn't improve results in women. Ten-year survival rates remained similar for bypass and angioplasty in diabetic women after adjustments for confounding baseline variables, leading investigators to conclude that risks and benefits of bypass vs. angioplasty "should be reconsidered" in women with diabetes and multi-vessel disease.

10:30 a.m. - Abstract #2800 - Patients with ICDs should remain physically active. Just how risky is strenuous exercise for patients with implantable cardioverter defibrillators (ICDs)? Current guidelines recommend only low-intensity exercise for ICD patients. Yale researchers surveyed 164 ICD patients (76 percent male, average age 57, 60 percent had coronary artery disease). Most had ventricular rhythm irregularities but no other physical limits to their ability to exercise. The median intensity level of exercises performed any time was 5 METS, with regular exercise ranging from walking (3.5 METS) to tennis and basketball (7 METS). Twenty-eight patients said they engage in more risky activities like biking, skiing or water sports. Twenty-three patients experienced 36 shocks from their ICDs, most during vigorous exercise such as running, doing yard work, competitive sports or biking. Median activity level during a shock episode was 5.5 METS. The first high-energy shock restored sinus rhythm in all ventricular tachycardia and ventricular fibrillation patients, and none caused serious injury. "Sports involving vigorous exercise may be safe in selected ICD patients," the study finds.

2 p.m. - Abstract #3544 - Results of hormone replacement study get rapid acceptance. Findings of last year's Women's Health Initiative (WHI) trial that hormone replacement therapy (HRT) with estrogen (E) plus progesterone (P) in post-menopausal women leads to excessive risk of cardiovascular disease is resulting in a "clear global decrease" in the use of HRT, a new study finds. Researchers assessed the impact of the WHI publication among 6,623 women, age 55 and over, taking part in an ongoing international drug trial. They found that 3.4 percent of North American women in that study were on E+P HRT after the WHI report, down from 5.9 percent before the report. Their results indicate a rapid acceptance of the results of the WHI trial both in North America and other countries, the scientists say. And despite a lack of data on effects of HRT with E alone, this therapy also was down in North American women, from 26 percent of post-menopausal women before the WHI report to 17.7 percent after.

2:15 p.m. - Abstract #3099 - Excess daytime sleepiness affects angina patients' quality of life. Sleep disturbances are a common problem among patients with coronary artery disease (CAD). New research finds that excessive daytime sleepiness predicts a poorer quality of life of CAD patients with chronic stable angina (chest pain). The Emory University study of 57 angina patients assessed quality of life (QOL) aspects via standard questionnaires, at baseline and follow-ups of one, three and four months. Extent of daytime sleepiness also was evaluated along with numerous other factors including years with CAD, body mass index and extent of other health problems. After controlling for clinical and demographic variables, researchers found daytime sleepiness to be "a significant negative predictor of QOL" in four statistical models studied. "Daytime sleepiness had pervasive and detrimental effects on chronic angina patients' QOL including generic and disease-specific physical function, disease perception and mental health," the team says, adding that interventions to correct sleep disturbances potentially can improve patients' QOL.

American Heart Association

Related Angioplasty Articles from Brightsurf:

Ticagrelor was not superior to clopidogrel to reduce heart attack risk during angioplasty
A new study found the rate of heart attack and severe complications before, during or soon after elective surgery to open a blocked artery was similar between patients treated with clopidogrel and those who received the more potent antiplatelet medication ticagrelor.

Study finds significant variability in doctors' angioplasty death rates
Some doctors have higher or lower than expected death rates from coronary angioplasty procedures, also known as percutaneous coronary intervention (PCI); however, doctors should not be judged solely on the rate of patients who die from the procedure.

Beta-blockers following angioplasty show little benefit for some older patients
Following coronary angioplasty, beta-blockers did not significantly improve mortality rates or reduce the number of future cardiovascular incidents for older patients with stable angina but no history of heart attack or heart failure, according to a study published today in the JACC: Cardiovascular Interventions.

Sleep disorders may predict heart events after angioplasty
People who have had procedures to open blocked heart arteries after acute coronary syndrome (ACS) may have a higher risk of death, heart failure, heart attack and stroke if they have sleep disorders, such as sleep apnea, compared to those who don't.

Reasons for hospital-level variations in bleeding post-angioplasty are unclear
The use of bleeding avoidance strategies has only a modest effect on the variation in bleeding rates post-angioplasty among hospitals performing this procedure, leaving about 70 percent of the causes for this variation unexplained, according to a study published today in JACC: Cardiovascular Interventions.

US prediction models for kidney injury following angioplasty hold up in Japan
Models developed by the American College of Cardiology NCDR CathPCI Registry to predict the likelihood of angioplasty patients developing acute kidney injury and acute kidney injury requiring dialysis have proven to be effective among patients in Japan.

IV beta blockers before angioplasty are safe, but offer no clinical benefit
Giving intravenous beta blockers before performing a coronary angioplasty in patients who had experienced the deadliest form of heart attack -- ST-segment elevation myocardial infarction (STEMI) -- was safe but did not reduce heart attack severity or improve blood flow from the heart's main pumping chamber, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

Life-threatening bowel ischemia can often be treated by balloon angioplasty
Acute mesenteric ischemia (AMI) can be successfully treated with endovascular therapy such as balloon angioplasty, according to research from the University of Eastern Finland.

Radial access used less than femoral approach for emergency angioplasty
Although using the radial artery as the access point for angioplasty has been linked to reduced bleeding compared to use of the femoral artery, only a small number of high-risk heart attack patients who undergo rescue angioplasty -- emergency procedures following failed therapy with clot-busting drugs -- are treated by radial access, according to a study published today in the Journal of the American College of Cardiology: Cardiovascular Interventions.

Use of rarely appropriate angioplasty procedures declined sharply
The number of angioplasty procedures classified as rarely appropriate declined sharply between 2010 and 2014, as did the number of those performed on patients with non-acute conditions, according to a study published today in the Journal of the American Medical Association and simultaneously presented at a meeting of the American Heart Association in Orlando.

Read More: Angioplasty News and Angioplasty Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to