Long-term blood pressure variation and risk of dementia

November 12, 2019

In a new research study published in the open access journal PLOS Medicine, Albert Hofman and colleagues at Erasmus MC University Medical Center, Rotterdam, the Netherlands and Harvard T.H. Chan School of Public Health, Boston, United States report that people who experienced substantial changes in blood pressure over the long term were at greater risk of dementia than those who did not.

The authors studied 5,273 people in Rotterdam, the Netherlands at a mean age of 67.6 years, who were free of dementia at the beginning of the study and were followed-up for 14.6 years. After adjustment for age, sex and other factors that could affect the findings, at 15 years people in the highest quintile, who exhibited an increase in systolic blood pressure, had a hazard ratio of 3.31 (95% Confidence Interval 2.11-5.18) for risk of dementia as compared with those in the quintile with the least change in blood pressure. Those in the lowest quintile, with the largest fall in systolic blood pressure, had a hazard ratio of 2.20 (95% CI 1.33-3.63) for dementia risk, again compared to those with the least change. Variations in both systolic and diastolic blood pressure led to similar findings.

Assuming that Hofman and colleagues' findings reflect a causal relationship between blood pressure variation and dementia, the authors note a "potential to prevent dementia through targeting blood pressure variability above and beyond the mere control of conventional blood pressure limits", and note that the association observed over a long time period implies that interventions should be implemented earlier in life to yield potential benefits.
Research Article


The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam; Netherlands Organization for the Health Research and Development (ZonMw); the Research Institute for Diseases in the Elderly (RIDE); the Ministry of Education, Culture and Science; the Ministry for Health, Welfare and Sports; the European Commission (DG XII), and the Municipality of Rotterdam. This work was partially supported by an unrestricted grant from the Janssen Prevention Center. YM was sponsored by the Rose Travelling Fellowship. The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Competing Interests:

The authors have declared that no competing interests exist.


Ma Y, Wolters FJ, Chibnik LB, Licher S, Ikram MA, Hofman A, et al. (2019) Variation in blood pressure and long-term risk of dementia: A population-based cohort study. PLoS Med 16(11): e1002933. https://doi.org/10.1371/journal.pmed.1002933

Image Credit: rawpixel, Pixabay

Author Affiliations:

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands

In your coverage please use this URL to provide access to the freely available paper: http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002933


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