Polymer Coating May Help Prevent Thrombosis Following Angioplasty

November 12, 1997

PITTSBURGH, Nov. 12 -- According to a study by researchers at the University of Pittsburgh Medical Center (UPMC), a thin polymer coating on the inside of coronary arteries may one day prevent blood clot formation called acute thrombosis, following angioplasty.

"Our study found that the formation of a barrier one molecule thick to prevent platelets from coming in contact with the injured vessel wall cells may lead to a novel and effective treatment of acute thrombosis following angioplasty," said J.E.B. Burchenal, M.D., assistant professor of medicine in the division of cardiology and principal investigator in the study.

The findings will be presented Nov. 12 at the annual scientific sessions of the American Heart Association in Orlando, Fla.

Acute thrombosis occurs in five percent of patients who undergo angioplasty and can lead to heart attack. This condition also may necessitate repeat coronary intervention or bypass surgery.

The study attempted to determine if the polymer, polyethylene glycol diisocyanate, could protect the damaged vascular wall from platelets in the blood long enough for the inside of the artery to heal and prevent the acute thrombosis process from beginning.

"This technique is unique because we are chemically attaching small polymer chains right onto the damaged tissue. The chains cover the sites the platelets attach to when a clot forms," said William Wagner, Ph.D., assistant professor of surgery and chemical engineering and study co-investigator.

Dr. Wagner developed the technique with Eric J. Beckman, Ph.D., and Alan J. Russell, Ph.D., both professors of chemical engineering at the University of Pittsburgh; and Christopher R. Deible, B.S., of Pitt's department of bioengineering.

Research was done at the UPMC's McGowan Center for Artificial Organ Development in collaboration with Dr. Burchenal.

Using animal models, the researchers performed angioplasty on femoral arteries. One set of arteries was then randomly treated with the polymer while another set was treated with a control solution of saline. After the blood flow was restored for one hour, the arteries were removed and platelet accumulations in the vessels were measured.

"Platelet deposition onto arteries treated with the polymer was significantly lower when compared with platelet deposits in the control arteries," said Dr. Burchenal. "The treatment with the polymer solution significantly inhibited platelet deposition for at least one hour. This study supports the hypothesis that treatment with the polymer solution masks surface adhesive proteins from platelet receptors in vivo."

For additional information about the University of Pittsburgh Medical Center, please access http://www.upmc.edu.

# # #

University of Pittsburgh Medical Center

Related Angioplasty Articles from Brightsurf:

Ticagrelor was not superior to clopidogrel to reduce heart attack risk during angioplasty
A new study found the rate of heart attack and severe complications before, during or soon after elective surgery to open a blocked artery was similar between patients treated with clopidogrel and those who received the more potent antiplatelet medication ticagrelor.

Study finds significant variability in doctors' angioplasty death rates
Some doctors have higher or lower than expected death rates from coronary angioplasty procedures, also known as percutaneous coronary intervention (PCI); however, doctors should not be judged solely on the rate of patients who die from the procedure.

Beta-blockers following angioplasty show little benefit for some older patients
Following coronary angioplasty, beta-blockers did not significantly improve mortality rates or reduce the number of future cardiovascular incidents for older patients with stable angina but no history of heart attack or heart failure, according to a study published today in the JACC: Cardiovascular Interventions.

Sleep disorders may predict heart events after angioplasty
People who have had procedures to open blocked heart arteries after acute coronary syndrome (ACS) may have a higher risk of death, heart failure, heart attack and stroke if they have sleep disorders, such as sleep apnea, compared to those who don't.

Reasons for hospital-level variations in bleeding post-angioplasty are unclear
The use of bleeding avoidance strategies has only a modest effect on the variation in bleeding rates post-angioplasty among hospitals performing this procedure, leaving about 70 percent of the causes for this variation unexplained, according to a study published today in JACC: Cardiovascular Interventions.

US prediction models for kidney injury following angioplasty hold up in Japan
Models developed by the American College of Cardiology NCDR CathPCI Registry to predict the likelihood of angioplasty patients developing acute kidney injury and acute kidney injury requiring dialysis have proven to be effective among patients in Japan.

IV beta blockers before angioplasty are safe, but offer no clinical benefit
Giving intravenous beta blockers before performing a coronary angioplasty in patients who had experienced the deadliest form of heart attack -- ST-segment elevation myocardial infarction (STEMI) -- was safe but did not reduce heart attack severity or improve blood flow from the heart's main pumping chamber, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

Life-threatening bowel ischemia can often be treated by balloon angioplasty
Acute mesenteric ischemia (AMI) can be successfully treated with endovascular therapy such as balloon angioplasty, according to research from the University of Eastern Finland.

Radial access used less than femoral approach for emergency angioplasty
Although using the radial artery as the access point for angioplasty has been linked to reduced bleeding compared to use of the femoral artery, only a small number of high-risk heart attack patients who undergo rescue angioplasty -- emergency procedures following failed therapy with clot-busting drugs -- are treated by radial access, according to a study published today in the Journal of the American College of Cardiology: Cardiovascular Interventions.

Use of rarely appropriate angioplasty procedures declined sharply
The number of angioplasty procedures classified as rarely appropriate declined sharply between 2010 and 2014, as did the number of those performed on patients with non-acute conditions, according to a study published today in the Journal of the American Medical Association and simultaneously presented at a meeting of the American Heart Association in Orlando.

Read More: Angioplasty News and Angioplasty Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.