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Cardiovascular health linked to cellular aging

November 13, 2016

NEW ORLEANS, Nov. 13, 2016 -- The age of a person's immune cells may predict risk of cardiovascular disease, according to a preliminary study presented at the American Heart Association's Scientific Sessions 2016.

DNA is packed into structures called chromosomes, and when cells copy themselves to replace old, damaged or dead cells, the tips of the chromosomes, called telomeres, shorten. Shorter telomere length is a sign of aging in a cell and has been associated with a number of diseases, including heart disease.

Researchers examined the relationship between telomere length of leukocytes, the body's immune cells, and overall cardiovascular health -- defined using the American Heart Association's Life Simple 7 metrics (smoking, physical activity, diet, body mass index, blood pressure, total cholesterol and fasting blood glucose).

Using data from the 1999-2002 National Health and Nutrition Examination Survey, researchers measured telomere length and overall cardiovascular health in 5,194 subjects, researchers found:
  • Participants with shorter leukocyte telomere length tended to have poorer cardiovascular health.
  • Leukocyte telomere length reflected cardiovascular health more accurately in women and white people.
The findings support the link between cardiovascular health and cell aging even though it can vary by gender and race. More research is needed to explain the gender and race differences, researchers said.
-end-
Samson Gebreab, Ph.D., National Human Genome Research Institute, Bethesda, Maryland.

Note: scientific presentation is 2:00 p.m. CT, Monday, Nov. 14 in room 346-347.

Statements and conclusions of study authors that are presented at American Heart Association scientific meetings are solely those of the study authors and do not necessarily reflect association policy or position. The association makes no representation or warranty as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at http://www.heart.org/corporatefunding.

American Heart Association

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