Nav: Home

New peripheral artery disease guidelines emphasize medical therapy and structured exercise

November 13, 2016

DALLAS, Nov. 13 2016 -- New guidelines for the treatment of peripheral artery disease (PAD), include recommendations on the use of antiplatelet therapy to reduce the risk of blood clots and statin drugs to lower cholesterol and advise PAD patients to participate in a structured exercise program. The joint American Heart Association/American College of Cardiology guidelines are published in the American Heart Association journal Circulation and the Journal of the American College of Cardiology.

Nearly 9 million Americans have PAD, a condition characterized by leg arteries that are narrowed and clogged by atherosclerosis, the same disease process that underlies heart attacks and stroke. Because the arteries are narrowed by plaque buildup, they cannot supply enough blood to the legs and people with PAD experience pain and difficulty walking. Left untreated, PAD can lead to disability and even leg amputations.

The new recommendations replace guidelines last updated in 2011. "Peripheral artery disease is a common disease with devastating consequences, and clinical practice guidelines are an important tool to improve the quality of care for patients with this disease," said Heather Gornik, M.D., vice chair of the PAD writing committee and cardiologist and vascular medicine specialist at the Cleveland Clinic.

When a patient has PAD, the goal of treatment is to prevent cardiovascular events such as heart attack and stroke and to improve walking ability and function. In some cases, vascular procedures to restore blood flow to the affected leg--such as angioplasty and stent placement using artery bypass surgery--are recommended. During angioplasty, special tubing with an attached deflated balloon is threaded through the leg arteries. The balloon is inflated to widen blocked areas where blood flow to the leg muscle has been reduced or cut off. Angioplasty is often combined with placement of a stent to help prop the artery open and decrease the chance of another blockage.

These vascular procedures are frequently used to potentially prevent amputation for patients with the most severe forms of PAD, including those with pain in the leg at rest due to a lack of blood flow and patients with a non-healing wound.

The new guidelines also included recommendations for when these vascular procedures should be considered for an additional group of patients who have less severe PAD but who continue to have significant limitations in walking despite treatment with medications and a structured exercise program. For these patients, vascular procedures to improve blood flow to the legs continue to be a reasonable treatment option according to the guidelines.

Regardless of whether vascular procedures are needed, all patients with PAD are at risk for developing blood clots in the legs and having a heart attack or stroke. Medical management recommendations continue to include the use of statin drugs, which reduce cholesterol in the blood, thereby making it less likely to accumulate within the walls of the arteries. The recommendations continue to advise healthcare providers to prescribe antiplatelet therapy such as aspirin or clopidogrel for patients with PAD, and the guidelines discuss situations where dual anti-platelet therapy, the combination of aspirin and clopidogrel, may be considered, such as after vascular surgery or stenting procedures.

As in earlier guidelines, physical activity is a cornerstone of managing PAD, and a new recommendation is for all patients with PAD to participate in a structured exercise program. Structured exercise should be individualized to the patient and should include specific instructions for the type, frequency, intensity and duration of exercise. The most effective form of structured exercise, according to the guidelines, is a supervised exercise program in a hospital or outpatient exercise facility, but other options include home- or community-based walking exercise or alternative forms of exercise such as upper-body exercises.

Previous guidelines emphasized the importance of smoking cessation for the patient with PAD, but the new guidelines go further-patients with PAD are now strongly advised to avoid second-hand smoke.

Another new recommendation for PAD patients is to get an annual flu shot to avoid cardiovascular complications of flu, such as heart attacks, because patients with PAD often have narrowed coronary arteries, a risk factor for heart attack.

Measuring ankle brachial index (ABI) by healthcare providers continues to be recommended for patients with symptoms and signs of PAD. The ankle-brachial index compares the blood pressure in the legs to the blood pressure in the arms to determine if there is significant narrowing of the arteries due to PAD. For patients without symptoms of PAD, but who are at increased risk, it is reasonable for healthcare providers to use the ABI to determine if PAD is present.

According to the guidelines, people at increased risk for PAD are those 65 and older, as well as people between 50 and 64 who smoke or have high cholesterol, high blood pressure, diabetes, or a family history of PAD. Others deemed at increased risk include people younger than 50 with diabetes plus one more additional factor, such as high cholesterol or high blood pressure. People with a history of atherosclerosis in another part of the body -- such as the coronary arteries (blood vessels to the heart), the carotid arteries (the main blood-ferrying vessel from the heart to the brain) or in the blood vessels of the abdomen or kidneys -- are also at increased risk.

"Periodically reassessing how we manage and treat complex diseases by incorporating the latest evidence is critical to ensure that clinicians are equipped to provide optimal care for their patients," said Marie Gerhard-Herman, M.D., chair of the writing group and a cardiologist at Brigham and Women's Hospital.
Writing group members: Neal R. Barshes, M.D., M.P.H.; Leila Mureebe, M.D., M.P.H; Matthew A. Corriere, M.D., M.S.; Jeffrey W. Olin, D.O.; Douglas E. Drachman, M.D.; Rajan Patel, M.D.; Lee A. Fleisher, M.D.; Judith G. Regensteiner, Ph.D.; Francis Gerry R. Fowkes, M.D.; Andres Schanzer, M.D.; Naomi M. Hamburg, M.D.; Mehdi H. Shishehbor, D.O., M.P.H., Ph.D.; Scott Kinlay, M.B.B.S., Ph.D; Kerry J. Stewart, Ed.D.; Robert Lookstein, M.D.; Diane Treat-Jacobson, Ph.D., R.N.; Sanjay Misra, M.D.; and M. Eileen Walsh, Ph.D.

Author disclosures are on the manuscript.

Additional Resources:

Heart image and physical activity photos are located in the right column of this release link
American Heart Association's Peripheral Artery Disease Website
Follow AHA/ASA news on Twitter @HeartNews.

About the American Heart Association: The American Heart Association/American Stroke Association receives funding mostly from individuals. Foundations and corporations donate as well, and fund specific programs and events. Strict policies are enforced to prevent these relationships from influencing the association's science content. Financial information for the American Heart Association, including a list of contributions from pharmaceutical companies and device manufacturers, is available at

About the American College of Cardiology: The American College of Cardiology is a 52,000-member medical society that is the professional home for the entire cardiovascular care team. The mission of the College is to transform cardiovascular care and to improve heart health. The ACC leads in the formation of health policy, standards and guidelines. The College operates national registries to measure and improve care, offers cardiovascular accreditation to hospitals and institutions, provides professional medical education, disseminates cardiovascular research and bestows credentials upon cardiovascular specialists who meet stringent qualifications. For more, visit

American Heart Association

Related Blood Pressure Articles:

Brain blood flow sensor discovery could aid treatments for high blood pressure & dementia
A study led by researchers at UCL has discovered the mechanism that allows the brain to monitor its own blood supply, a finding in rats which may help to find new treatments for human conditions including hypertension (high blood pressure) and dementia.
Here's something that will raise your blood pressure
The apelin receptor (APJ) has been presumed to play an important role in the contraction of blood vessels involved in blood pressure regulation.
New strategy for treating high blood pressure
The key to treating blood pressure might lie in people who are 'resistant' to developing high blood pressure even when they eat high salt diets, shows new research published today in Experimental Physiology.
Arm cuff blood pressure measurements may fall short for predicting heart disease risk in some people with resistant high blood pressure
A measurement of central blood pressure in people with difficult-to-treat high blood pressure could help reduce risk of heart disease better than traditional arm cuff readings for some patients, according to preliminary research presented at the American Heart Association's Hypertension 2019 Scientific Sessions.
Heating pads may lower blood pressure in people with high blood pressure when lying down
In people with supine hypertension due to autonomic failure, a condition that increases blood pressure when lying down, overnight heat therapy significantly decreased systolic blood pressure compared to a placebo.
The Lancet Neurology: High blood pressure and rising blood pressure between ages 36-53 are associated with smaller brain volume and white matter lesions in later years
A study of the world's oldest, continuously-studied birth cohort tracked blood pressure from early adulthood through to late life and explored its influence on brain pathologies detected using brain scanning in their early 70s.
Blood pressure control is beneficial, is it not?
Until recently, physicians had generally assumed that older adults benefit from keeping their blood pressure below 140/90 mmHg.
The 'blue' in blueberries can help lower blood pressure
A new study published in the Journal of Gerontology Series A has found that eating 200g of blueberries every day for a month can lead to an improvement in blood vessel function and a decrease in systolic blood pressure in healthy people.
How to classify high blood pressure in pregnancy?
The American Heart Association (AHA) and the American College of Cardiology (ACC) changed their guidance to lower the threshold criteria for hypertension in adults.
Discovery could advance blood pressure treatments
A team of Vanderbilt University Medical Center researchers, working with the US Department of Veteran's Affairs (VA), has discovered genetic associations with blood pressure that could guide future treatments for patients with hypertension.
More Blood Pressure News and Blood Pressure Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Clint Smith
The killing of George Floyd by a police officer has sparked massive protests nationwide. This hour, writer and scholar Clint Smith reflects on this moment, through conversation, letters, and poetry.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Dispatch 6: Strange Times
Covid has disrupted the most basic routines of our days and nights. But in the middle of a conversation about how to fight the virus, we find a place impervious to the stalled plans and frenetic demands of the outside world. It's a very different kind of front line, where urgent work means moving slow, and time is marked out in tiny pre-planned steps. Then, on a walk through the woods, we consider how the tempo of our lives affects our minds and discover how the beats of biology shape our bodies. This episode was produced with help from Molly Webster and Tracie Hunte. Support Radiolab today at