Two differing medications used during heart procedure are both safe and effective, study finds

November 13, 2016

Two differing blood clot prevention medications are just as safe and effective for patients undergoing percutaneous coronary intervention, a non-surgical procedure to open blood vessels narrowed by plaque buildup, according to a new study.

The scientific community has proposed both medications as potentially superior to longer-term anticoagulation treatments for patients undergoing the procedure.

The new study by researchers from the Intermountain Medical Center Heart Institute in Salt Lake City sought to discover which of the two short-term treatment methods --using the drug heparin combined with a short-term (less than six hours) infusion of tirofiban, or short-term periprocedural bivalirudin, another medication that helps prevent blood clots during the procedure -- was more effective.

Through this observational study of patients undergoing successful elective percutaneous coronary intervention, the Intermountain researchers found that the risk after 30 days of major bleeding, and one-year risk of death, heart attack and urgent repeat PCI, was low and not significantly different between the two treatment methods.

Results of the study will be presented during the American Heart Association Scientific Sessions in New Orleans on Sunday, November 13, at 3:45 pm, CST.

"Bivalirudin has been considered the gold standard for reducing bleeding during percutaneous coronary intervention, but our study shows heparin plus short-term tirofiban is just as good and possibly better," said Intermountain Medical Center Heart Institute cardiologist J. Brent Muhlestein, MD, the lead author on the study. "The results certainly justify a randomized clinical trial to explore identified trends."

Researchers studied results from patients who underwent percutaneous coronary intervention between January 2013 and December 2015. Of the 857 patients enrolled in the study, 402 received heparin plus short-term tirofiban treatment and 455 received bivalirudin. The patients were between the ages of 51 and 78.

There was a slight reduction in major bleeding and death with the use of heparin plus short-term tirofiban over bivalirudin alone, but due to the overall low incidence of adverse events, the difference did not reach statistical significance.

The 30-day incidence of TIMI major bleeding score was 1.2 percent for patients treated with heparin and tirofiban and 3.1 percent for bivalirudin patients.
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In addition to Dr. Muhlestein, other members of the Intermountain Medical Center Heart Institute research team include Heidi T. May, PhD; Tami L. Bair; Viet Le, PA; Jeffrey L. Anderson, MD; Brian Whisenant, MD; Kirk U. Knowlton, MD; and Donald L. Lappé, MD.

The Intermountain Medical Center is the flagship facility for the Intermountain Healthcare system, which is based in Salt Lake City.

Intermountain Medical Center

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Two differing medications used during heart procedure are both safe and effective, study finds
Two differing blood clot prevention medications are just as safe and effective for patients undergoing percutaneous coronary intervention, a non-surgical procedure to open blood vessels narrowed by plaque buildup, according to a new study.

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