Researchers from CSIC identify the genetic program that allows us to see in 3D

November 13, 2020

A group of researchers from the Institute of Neurosciences UMH-CSIC, in Alicante, led by Dr. Eloísa Herrera, has discovered a genetic program essential for the formation of bilateral circuits, such as the one that makes possible 3D vision or the one enabling motor coordination. The finding, carried out in mice, is published today in Science Advances.

This new study not only clarifies how images are transmitted from the retina to the brain in order to see in 3D, but also helps us to understand how laterality is established in other neuronal circuits, such as the one that allows us to coordinate movements at both sides of the body, Dr. Herrera explains.

The work also reveals the important role of a protein known as Zic2 in the regulation of a signaling pathway called Wnt, which is fundamental for the correct development of the embryo and is highly conserved among species, from fruit flies to humans, including mice, in which this study has been carried out.

This pathway is usually altered in pathological scenarios such as spina bifida or other disorders associated with incomplete closure of the neural tube as well as in several types of cancer. The new details described in this work about the regulation of this pathway through Zic2 will help to understand the origin of this type of pathologies to try to prevent their appearance.


The ability to perceive the 3D world and respond appropriately to external stimuli largely depends on a type of neural circuits known as bilateral that communicate the two brain hemispheres and are essential for many of the tasks we perform daily.

These bilateral circuits require both the crossing of one part of the nerve fibers to the contralateral brain hemisphere from which they originate and the permanence of the other half in its originating hemisphere. "The genetic program we have identified ensures that part of the neurons located in the retina carry visual information to the opposite brain hemisphere, and the action of a protein called Zic2 turns off this program in another group of retinal neurons so that the visual signal also reaches the same hemisphere," explains Eloísa Herrera.

Years ago, Dr. Eloísa Herrera's group discovered that Zic2 makes bilateralism possible by ensuring that part of the extensions of the neurons (axons) remain in the same hemisphere from which they originated. And in this new work, they describe that in order to ensure that the axons remain in the same hemisphere, Zic2 turns off the genetic program that makes them cross over to the opposite hemisphere.

"This finding has allowed us to identify the contralateral program and observe that it shares common elements with a well-known signaling pathway, called Wnt, which is also involved in many other processes of the embryonic development," highlights Eloísa Herrera, who directs the group of "Development and assembly of bilateral circuits in the nervous system" at the Institute of Neurosciences UMH-CSIC in Alicante.


This discovery has been made in the visual pathway of mice, which is similar to the visual pathway of other mammals, including our species. Each of the two optical nerves that connect the retinas to the brain is formed by a multitude of nerve fibers. The two optic nerves converge in an X-shaped structure, called the optic chiasm, located at the base of the brain. Here takes place the crossing of information between both cerebral hemispheres that makes possible the vision in 3D.

"Each eye sends visual information to both sides of the brain because about half of the axons of the neurons located in the retina cross the mid-brain line to connect with the opposite hemisphere, while the other half avoids this crossing to project into the brain hemisphere on the same side from which they came. This anatomical organization allows the brain to fuse the slightly different images it receives from each eye to create the sensation of three-dimensionality," explains Dr. Herrera.

It is precisely at the optic chiasm where Zic2 acts as a switch to turn off the genetic program that allows the axons to pass to the other brain hemisphere. This "switch on the pathway" is crucial for the brain to create a three-dimensional image from two flat images coming from the retina.

Spanish National Research Council (CSIC)

Related Neurons Articles from Brightsurf:

Paying attention to the neurons behind our alertness
The neurons of layer 6 - the deepest layer of the cortex - were examined by researchers from the Okinawa Institute of Science and Technology Graduate University to uncover how they react to sensory stimulation in different behavioral states.

Trying to listen to the signal from neurons
Toyohashi University of Technology has developed a coaxial cable-inspired needle-electrode.

A mechanical way to stimulate neurons
Magnetic nanodiscs can be activated by an external magnetic field, providing a research tool for studying neural responses.

Extraordinary regeneration of neurons in zebrafish
Biologists from the University of Bayreuth have discovered a uniquely rapid form of regeneration in injured neurons and their function in the central nervous system of zebrafish.

Dopamine neurons mull over your options
Researchers at the University of Tsukuba have found that dopamine neurons in the brain can represent the decision-making process when making economic choices.

Neurons thrive even when malnourished
When animal, insect or human embryos grow in a malnourished environment, their developing nervous systems get first pick of any available nutrients so that new neurons can be made.

The first 3D map of the heart's neurons
An interdisciplinary research team establishes a new technological pipeline to build a 3D map of the neurons in the heart, revealing foundational insight into their role in heart attacks and other cardiac conditions.

Mapping the neurons of the rat heart in 3D
A team of researchers has developed a virtual 3D heart, digitally showcasing the heart's unique network of neurons for the first time.

How to put neurons into cages
Football-shaped microscale cages have been created using special laser technologies.

A molecule that directs neurons
A research team coordinated by the University of Trento studied a mass of brain cells, the habenula, linked to disorders like autism, schizophrenia and depression.

Read More: Neurons News and Neurons Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to