Nav: Home

Stress-induced changes in maternal gut could negatively impact offspring for life

November 14, 2016

SAN DIEGO - Prenatal exposure to a mother's stress contributes to anxiety and cognitive problems that persist into adulthood, a phenomenon that could be explained by lasting - and potentially damaging - changes in the microbiome, according to new research in mice.

When pregnant mice were exposed to stress in the study, it appeared to change the makeup of the bacteria in both their guts and placentas, as well as in the intestinal tracts of their female offspring, researchers at The Ohio State University found. And those microbial changes lasted into adulthood.

On top of that, the mice with stressed mothers struggled in tests aimed at gauging anxiety and cognitive health compared with female offspring of mice that were not stressed during pregnancy. And markers of inflammation increased in the placenta, the fetal brain and the adult brain of the offspring while a supportive protein called brain-derived neurotrophic factor (BDNF) decreased.

"More and more, doctors and researchers are understanding that naturally occurring bacteria are not just a silent presence in our body, but that they contribute to our health," said Tamar Gur, the lead researcher and assistant professor of psychiatry & behavioral health, neuroscience and obstetrics & gynecology at Ohio State.

"These mice were more anxious, they spent more time in dark, closed spaces and they had a harder time learning cognitive tasks even though they were never stressed after birth." Gur presented the study on Nov. 14 in San Diego at Neuroscience 2016, the annual meeting of the Society for Neuroscience.

Previous studies have found associations between maternal stress in both animals and people to later mental health and behavioral problems in their offspring. This study could begin to explain what's at play in that relationship.

"We already understand that prenatal stress can be bad for offspring, but the mystery is how," said Gur, a psychiatrist who is a member of Ohio State Wexner Medical Center's Institute for Behavioral Medicine Research.

Gur said microbes from a mother's gastrointestinal and reproductive tracts are the first to colonize in a developing fetus (and in newborns). That makes the bacteria an interesting potential explanation of why and how stress before an animal or person is born could prompt mental illness that can last a lifetime.

This study is pointing to alterations in the microbes that live in the placenta and outlines changes found in the placentas of fetal mice that had stressed mothers.

Gur and her colleagues found significant microbial changes to the placentas of the female offspring of stressed mice. They also found alterations in inflammation and growth factors in the placenta, pointing to changes in how the microbes were influencing important dynamics before birth.

And in the female offspring of the stressed mice, the researchers found a lower ability to learn and higher anxiety-like behavior compared to the offspring of non-stressed mother mice. Gur said the team found interesting changes in the male offspring as well, but the details of that part of the study are still in the works.

Gur said she wants to know more about the links between the brain and the bacteria that live in the gut, and she and her colleagues have plans to expand their investigation to pregnant women and their babies. Perhaps one day the work will lead to knowledge about how probiotics could help mitigate the effects of stress and the downstream repercussions, but it's too soon now to say if they would have any impact, she said.

The stressed mother mice underwent two hours per day for seven days of restraint meant to induce stress. For comparison, the researchers left another group of pregnant mice undisturbed during gestation. Gut bacteria were assessed using fecal samples from the mice.

Gur stressed that the message here is not that mothers are to blame should their children suffer mental illness later in life. Rather, she said, this scientific development presents an opportunity to talk more about the importance of mental health in general and during pregnancy.

"As a psychiatrist who treats pregnant women, if you're stressed, anxious or depressed, I think pregnancy is a prime time for intervention," Gur said. "And what's good for mom is good for the baby."
-end-
The study was supported by the March of Dimes and the Brain & Behavior Research Foundation. Other researchers who worked on the study were Michael T. Bailey, Lena Shay, Sydney Fisher, Adidti Vadodkar and Vanessa Varaljay.

CONTACT: Tamar Gur, Tamar.Gur@osumc.edu

Written by Misti Crane, 614-292-5220; Crane.11@osu.edu

Ohio State University

Related Bacteria Articles:

Siblings can also differ from one another in bacteria
A research team from the University of Tübingen and the German Center for Infection Research (DZIF) is investigating how pathogens influence the immune response of their host with genetic variation.
How bacteria fertilize soya
Soya and clover have their very own fertiliser factories in their roots, where bacteria manufacture ammonium, which is crucial for plant growth.
Bacteria might help other bacteria to tolerate antibiotics better
A new paper by the Dynamical Systems Biology lab at UPF shows that the response by bacteria to antibiotics may depend on other species of bacteria they live with, in such a way that some bacteria may make others more tolerant to antibiotics.
Two-faced bacteria
The gut microbiome, which is a collection of numerous beneficial bacteria species, is key to our overall well-being and good health.
Microcensus in bacteria
Bacillus subtilis can determine proportions of different groups within a mixed population.
Right beneath the skin we all have the same bacteria
In the dermis skin layer, the same bacteria are found across age and gender.
Bacteria must be 'stressed out' to divide
Bacterial cell division is controlled by both enzymatic activity and mechanical forces, which work together to control its timing and location, a new study from EPFL finds.
How bees live with bacteria
More than 90 percent of all bee species are not organized in colonies, but fight their way through life alone.
The bacteria building your baby
Australian researchers have laid to rest a longstanding controversy: is the womb sterile?
Hopping bacteria
Scientists have long known that key models of bacterial movement in real-world conditions are flawed.
More Bacteria News and Bacteria Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: The Power Of Spaces
How do spaces shape the human experience? In what ways do our rooms, homes, and buildings give us meaning and purpose? This hour, TED speakers explore the power of the spaces we make and inhabit. Guests include architect Michael Murphy, musician David Byrne, artist Es Devlin, and architect Siamak Hariri.
Now Playing: Science for the People

#576 Science Communication in Creative Places
When you think of science communication, you might think of TED talks or museum talks or video talks, or... people giving lectures. It's a lot of people talking. But there's more to sci comm than that. This week host Bethany Brookshire talks to three people who have looked at science communication in places you might not expect it. We'll speak with Mauna Dasari, a graduate student at Notre Dame, about making mammals into a March Madness match. We'll talk with Sarah Garner, director of the Pathologists Assistant Program at Tulane University School of Medicine, who takes pathology instruction out of...
Now Playing: Radiolab

What If?
There's plenty of speculation about what Donald Trump might do in the wake of the election. Would he dispute the results if he loses? Would he simply refuse to leave office, or even try to use the military to maintain control? Last summer, Rosa Brooks got together a team of experts and political operatives from both sides of the aisle to ask a slightly different question. Rather than arguing about whether he'd do those things, they dug into what exactly would happen if he did. Part war game part choose your own adventure, Rosa's Transition Integrity Project doesn't give us any predictions, and it isn't a referendum on Trump. Instead, it's a deeply illuminating stress test on our laws, our institutions, and on the commitment to democracy written into the constitution. This episode was reported by Bethel Habte, with help from Tracie Hunte, and produced by Bethel Habte. Jeremy Bloom provided original music. Support Radiolab by becoming a member today at Radiolab.org/donate.     You can read The Transition Integrity Project's report here.