Nav: Home

Ibuprofen may block damage from fetal-alcohol exposure

November 14, 2017

COLUMBUS, Ohio - An anti-inflammatory drug may have the potential to stall the damaging effects of alcohol on the fetal brain, a new study suggests.

Ibuprofen reduced neuroinflammation and behavioral signs of alcohol exposure in a rat model of fetal alcohol spectrum disorders (FASD).

The study was the first to directly link alcohol-induced inflammation in the hippocampus to cognitive impairment later in the life, said Derick Lindquist, senior author and a professor of psychology at The Ohio State University.

The findings, which appear in the journal Behavioural Brain Research, could have eventual implications reaching beyond fetal alcohol spectrum disorders, because neuroinflammation is a hallmark of many neurological diseases, he said.

In humans, fetal exposure to alcohol can lead to a cluster of life-altering problems including trouble learning, remembering and paying attention. Though estimates are imprecise, experts estimate that as many as two to five of every 100 U.S. schoolchildren have lasting problems resulting from early alcohol exposure, according to the Centers for Disease Control and Prevention.

Recent related research showed that neuroinflammation soon after birth can impair learning and memory later in life and that anti-inflammatory treatment has the power to prevent those impairments.

In this study, Lindquist and his co-authors set out to examine the role of neuroinflammation in the development of fetal alcohol spectrum disorders and cognitive dysfunction.

Some of the animals in the study were exposed to alcohol four to nine days after birth - the scientific equivalent of the third trimester in a human pregnancy. Alcohol-exposed rats given ibuprofen had lower levels of inflammation in the brain than those given saline solution. Twenty-five days later they also exhibited enhanced long-term memory.

The research helps define the role of the brain's immune system -- and of inflammation in particular -- in the development of cognitive dysfunction after fetal alcohol exposure, Lindquist said.

While it's too soon to speculate on implications in humans, it could pave the way for future research into potential treatments for fetal alcohol spectrum disorders and other neurological problems, said lead author Molly Goodfellow, who worked on the study as an Ohio State graduate student and is now at the University of Maryland.

"We hope that our work will promote future studies to determine how long neuroinflammation persists after alcohol exposure and if anti-inflammatory therapies might work if administered after birth or later in life to improve cognitive function in people with FASD."

Lindquist and Goodfellow said it's important to note that ibuprofen is generally not recommended for pregnant women because of risks to the mother and the fetus.

"At this point in our study, the ibuprofen is kind of like using a sledgehammer to reduce neuroinflammation. It's possible other anti-inflammatory drugs could have similar pro-cognitive effects with less risk," Lindquist said.
-end-
Youn Ju Shin, a neuroscience researcher at Ohio State, also worked on this study.

CONTACT: Derick Lindquist, 614-292-2236; Lindquist.40@osu.edu

Written by Misti Crane, 614-292-5220; Crane.11@osu.edu

Ohio State University

Related Alcohol Articles:

This is your brain on alcohol (video)
It's almost time to ring in 2017. And since most New Year's celebrations include alcohol, Reactions' latest episode explains the chemistry behind its effects -- drunkenness, frequent bathroom breaks and occasionally poor decision-making.
Heavy alcohol use changes adolescents' brain
Heavy alcohol use during adolescence alters the development of brain, according to a recent study from the University of Eastern Finland and Kuopio University Hospital.
Maryland's 2011 alcohol sales tax reduced alcohol sales, study suggests
Maryland's 2011 increase in the alcohol sales tax appears to have led to fewer purchases of beer, wine and liquor in the state, suggesting reduced alcohol use, new Johns Hopkins Bloomberg School of Public Health research indicates.
Alcohol related deaths are likely to increase after cuts in alcohol taxation
Alcohol related deaths are most likely set to increase in England as incomes outstrip rises in taxation, argue experts in The BMJ today.
Alcohol aromatherapy eases nausea in the ER
Nauseated patients in the emergency department who sniffed pads saturated with isopropyl alcohol were twice as likely to obtain relief from their symptoms as nauseated patients who sniffed pads saturated with saline solution, according to a study published online today in Annals of Emergency Medicine ('Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial').
Alcohol ads linked to teen alcohol brand choices
Overall exposure to brand-specific alcohol advertising is a significant predictor of underage youth alcohol brand consumption, with youth ages 13 to 20 more than five times more likely to consume brands that advertise on national television and 36 percent more likely to consume brands that advertise in national magazines compared to brands that don't advertise in these media.
Should women consume alcohol during pregnancy?
In The BMJ this week, experts discuss the evidence and current guidelines on the controversial topic of alcohol consumption during pregnancy.
The Lancet: Harmful alcohol use linked with increased risk of alcohol-related cancers and injury
A new study of alcohol use in countries of all income levels shows that current use increases the risk of alcohol-related cancers and injury, with no reduction in risk of mortality or cardiovascular disease overall.
Web interventions for alcohol misuse
A systematic evidence review published in Annals of Internal Medicine finds that low-intensity electronic interventions may slightly reduce alcohol consumption among adults and college students, but may be ineffective for reducing binge-drinking frequency and the negative social consequences associated with alcohol misuse.
Marijuana users substitute alcohol at 21
A recent study looked at marijuana and alcohol use in people between the ages of 18 and 24.

Related Alcohol Reading:

Alcohol Explained
by William Porter (Author)

Alcohol Explained is the definitive, ground-breaking guide to alcohol and alcoholism. It explains how alcohol affects human beings on a chemical, physiological and psychological level, from those first drinks right up to chronic alcoholism. Alcoholism and problem drinking seems illogical to those on the outside, indeed it is equally perplexing for the alcoholic or problem drinker. This book provides a logical, easy to follow explanation of the phenomenon and detailed instructions on how to beat it. Despite being entirely scientific and factual in nature the book is presented in an accessible... View Details


Alcohol Lied to Me: The Intelligent Way to Escape Alcohol Addiction
by Craig Beck (Author)

Craig Beck is a well-regarded family man with two children, a nice home and a successful media career. A director of several companies & at one time the trustee of a large children’s charity. Craig was a successful & functioning professional man in spite of a ‘2 bottles of wine a night’ drinking habit. For 20 years he struggled with problem drinking, all the time refusing to label himself an alcoholic because he didn't believe he met the stereotypical image that the word portrayed. He tried countless ways to cut down; attempting ‘dry months’, banning himself from drinking spirits,... View Details


The 30-Day No Alcohol Challenge: Your Simple Guide To Easily Reduce Or Quit Alcohol
by James Swanwick (Author)

YOU’RE NOT AN ALCOHOLIC BUT SOMETIMES DRINK TOO MUCH… Are you often unmotivated, stressed, lacking energy and tired? Are you sick of hangovers? Do you want to stop missing out on life, regain your health, improve your relationships and enjoy greater control, clarity, focus and freedom? When you quit alcohol for just 30 days, you can transform your life. You will look and feel better, save and make money and be happier. James Swanwick is a former social drinker. He is an Australian-American entrepreneur, award-winning journalist and former ESPN SportsCenter anchor. In this groundbreaking... View Details


Alcohol: How to Give It Up and Be Glad You Did
by Philip Tate PhD (Author), Albert Ellis (Introduction)

This practical, comprehensive, and easy to use book helps alcohol abusers understand their behavior, but provides practical steps that anyone can use to solve an alcohol problem. Written by a cognitive-behavioral psychologist, this book includes chapters on overcoming low self-esteem, depression, stress, attending self-help groups, and living a better life after quitting. Each chapter contains specific self-help techniques. Recommended by SMART Recovery.
View Details


Alcohol: Social Drinking in Cultural Context (Routledge Series for Creative Teaching and Learning in Anthropology)
by Janet Chrzan (Author)

Alcohol: Social Drinking in Cultural Context critically examines alcohol use across cultures and through time. This short text is a framework for students to self-consciously examine their beliefs about and use of alcohol, and a companion text for teaching the primary concepts of anthropology to first-or second year college students.

View Details


Alcohol: Soviet Anti-Alcohol Posters
by Alexei Plutser-Sarno (Author), Damon Murray (Editor), Stephen Sorrell (Editor)

Soviet propaganda against the demon drink: the latest in Fuel’s Russian pop culture series
From the acclaimed authors of the Russian Criminal Tattoo Encyclopaedias and Soviet Space Dogs comes Alcohol, a glorious and exhaustive collection of previously unpublished Soviet anti-alcohol posters. The book includes examples from the 1960s through to the 1980s, but focuses on posters produced during Mikhail Gorbachev’s campaign initiated in 1985. These posters attempted to sober up Soviet citizens by forcing them to confront the issues associated with excessive... View Details


Allen Carr's Easyway to Control Alcohol
by Allen Carr (Author)

Allen Carr established himself as the world's greatest authority on helping people stop smoking and his internationally best-selling Easy Way to Stop Smoking has been published in over 40 languages and sold more than 10 million copies.In his Easy Way to Control Alcohol Allen applies his revolutionary method to drinking. With startling insight into why we drink and clear, simple, step-by-step instructions, he shows you the way to escape from the "alcohol trap" in the time it takes to read this book.His unique method removes the feeling of deprivation and works without using willpower. Allen... View Details


Alcohol and Drug Counselor Exam Practice Questions: ADC Practice Tests & Review for the International Examination for Alcohol & Drug Counselors (Mometrix Test Preparation)
by ADC Exam Secrets Test Prep Team (Author)

***Your #1 Alcohol and Drug Counselor Practice Test Resource***

Alcohol and Drug Counselor Exam Practice Questions are the simplest way to prepare for the Alcohol and Drug Counselor test. Practice is an essential part of preparing for a test and improving a test taker's chance of success. The best way to practice taking a test is by going through lots of Alcohol and Drug Counselor practice questions.

If someone has never taken a Alcohol and Drug Counselor practice test, then they are unprepared for the types of questions and answer choices that they will... View Details


ServSafe Alcohol: Fundamentals of Responsible Alcohol Service with Answer Sheet (2nd Edition)
by National Restaurant Association (Author)

ServSafe Alcohol is vital, practical and current responsible alcohol service training. It implements the same approach ServSafe® pioneered for the industry's most recognized food safety training and certification. ServSafe Alcohol includes the latest studies and science-based information, explores real-world situations and makes it all engaging and accessible with the latest instructional design techniques. That makes ServSafe Alcohol a smart training solution for every operation and every classroom.  The ServSafe Alcohol program was developed with input from experts... View Details

Best Science Podcasts 2017

We have hand picked the best science podcasts for 2017. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Simple Solutions
Sometimes, the best solutions to complex problems are simple. But simple doesn't always mean easy. This hour, TED speakers describe the innovation and hard work that goes into achieving simplicity. Guests include designer Mileha Soneji, chef Sam Kass, sleep researcher Wendy Troxel, public health advocate Myriam Sidibe, and engineer Amos Winter.
Now Playing: Science for the People

#448 Pavlov (Rebroadcast)
This week, we're learning about the life and work of a groundbreaking physiologist whose work on learning and instinct is familiar worldwide, and almost universally misunderstood. We'll spend the hour with Daniel Todes, Ph.D, Professor of History of Medicine at The Johns Hopkins University, discussing his book "Ivan Pavlov: A Russian Life in Science."