Advances in the detection of the postoperative progress of abdominal aortic aneurysm

November 14, 2019

An abdominal aortic aneurysm is a focal dilation of the abdominal aorta, that if not treated, tends to grow and may rupture. The most common treatment is EndoVascular Aneurysm Repair (EVAR), which requires patients to undergo lifelong postoperative surveillance based on computed tomography angiography (CTA) due to the possible appearance of complications. These complications may again lead to aneurysm dilation and rupture.

To monitor the disease, advanced tools for the quantitative analysis of clinical images to support physicians are lacking. Currently, the approach consists of evaluating diameter changes to the aneurysm along time to infer the progress of the patient and the postoperative risk of aneurysm rupture. An increased diameter is usually associated with a higher rupture risk, but there are some small aneurysms that rupture, whereas other larger ones remain stable.

This means that diameter-based rupture risk assessment is not suitable for all cases, and there is increasing evidence that the biomechanical behaviour of the aneurysm may provide additional valuable information regarding the progression of the disease and the risk of rupture.

A study published recently in Frontiers in Bioengineering and Biotechnology, coordinated by Miguel A. González Ballester (ICREA-DTIC) and Iván Macía (VicomTech), offers a promising methodology for post-operative CTA time-series registration and subsequent aneurysm biomechanical strain analysis, which correlates with the patient's long-term prognosis.

The study was conducted entirely in Catalonia and the Basque Country by researchers from the BCN-MedTech Research Unit of the Department of Information and Communication Technologies (DTIC) at UPF, together with the centres in the Basque Country: VicomTech Foundation of San Sebastián, the Bioengineering area of the BioDonostia Health Research Institute and Donostia University Hospital.

Quantitative descriptors extracted from registrations of deformations of the aorta

From the deformations obtained from CTA image registration, the researchers have extracted quantitative descriptors of the main components of the tensile and compressive strain fields. "Evaluated on 22 patients, our approach yields a mean area under the curve of 88.6% when correlating the strain-based quantitative descriptors with the long-term patient prognosis", says Karen López-Linares, first author of the work, linked to the SIMBIOsys research group and researcher at BCN-MedTech, the VicomTech Foundation and the BioDonostia Health Research Institute.

"This suggests that the descriptors directly extracted from the CTA images are able to capture the biomechanical behaviour of the aneurysm without relying on finite element modelling and simulation", add Jérôme Noailly, a specialist in computational biomechanics, and Miguel A. González Ballester (ICREA DTIC), both members of BCN-MedTech and co-authors of the article.

Biomarkers for the most difficult and uncertain cases of aneurysm

In addition, the authors highlight that the extracted descriptors set the basis for possible future imaging biomarkers that may be used in the clinical practice. These biomarkers may be used to assess patient prognosis and to enable informed decision making after an EVAR intervention, the most common treatment for aortic and abdominal aneurysms, and especially in difficult, uncertain cases.
-end-


Universitat Pompeu Fabra - Barcelona

Related Aneurysm Articles from Brightsurf:

New abdominal aortic aneurysm genes identified, could help pinpoint those at risk
A study of US veterans identified 14 genes that may predict the risk of abdominal aortic aneurysm.

Temple researchers track new path to therapeutic prevention of abdominal aortic aneurysm
New research by scientists at the Lewis Katz School of Medicine at Temple University suggests that abdominal aortic aneurysm (AAA) can be prevented therapeutically.

Researchers find no benefit for treatment used to avoid surgery for abdominal aortic aneurysm
A new landmark study by researchers at the University of Maryland School of Medicine (UMSOM) found that patients with a vascular condition, called abdominal aortic aneurysm, received no benefits from taking a common antibiotic drug to reduce inflammation.

Genetic scoring can identify more men at risk for aortic aneurysm
A genetic risk score from a blood test identified more men age 50 and older who are at higher risk of an aortic aneurysm and could benefit from ultrasound screening.

New findings boost understanding of arterial aneurysm
Abdominal arterial (or aortic) aneurysm in older men is associated with levels of certain subtypes of white blood cells, a study from the University of Gothenburg, Sweden, shows.

Presence of blood clot associated with rapid aortic aneurysm growth
The presence of a blood clot on the wall of the aorta in people with abdominal aortic aneurysms is associated with more rapid, potentially dangerous growth in the aneurysm, according to a major new study.

Advances in the detection of the postoperative progress of abdominal aortic aneurysm
A study published in Frontiers in Bioengineering and Biotechnology by a team of researchers from BCN MedTech with the VICOMTech Foundation in San Sebastian, the BioDonostia Health Research Institute and Donostia University Hospital, offers a promising methodology for post-operative CTA time-series registration and subsequent aneurysm biomechanical strain analysis, which correlates with the patient's long-term prognosis.

Can aspirin decrease the rate of intracranial aneurysm growth?
Researchers investigated whether aspirin can aid in the prevention of intracranial aneurysm rupture by hindering aneurysm growth.

Researchers uncover new cause of abdominal aortic aneurysm
Researchers have discovered that a family of lipids (fats) contribute to the development of a serious aortic disease, by driving clotting in the blood vessel wall.

'Aneurysm Number' may help surgeons make treatment decisions
Aneurysms form as abnormal bulges over an artery, and, if ruptured, can lead to serious health complications or even death.

Read More: Aneurysm News and Aneurysm Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.