Jefferson researchers find lack of protein in obese people is risk factor for kidney, heart disease

November 15, 2005

Jefferson researchers have found that mice with low levels of the protein hormone adiponectin may also have high levels of a protein called albumin which, in humans, may be a sign of kidney disease. This study provides further support for the theory that kidney disease may be a more important risk factor for heart disease than is cholesterol.

Nephrologists at Thomas Jefferson University, Philadelphia, led by Kumar Sharma, M.D., director of Jefferson's Center for Diabetic Kidney Disease, reported on the results during Renal Week in November 2005 at the American Society of Nephrology in Philadelphia.

The researchers worked with two sets of mice. They found a significant negative correlation between the urine albumin and levels of the hormone adiponectin in obese mice. To prove the relationship, they also studied mice without adiponectin ("adiponectin knockout") compared to wild-type mice whose levels were normal. The team found that the knockout mice had three times the level of urine albumin than the wild-type mice.

Jefferson Researchers find link to Kidney Disease-2

In a separate study Jefferson researchers measured the adiponectin levels of a group of obese African American adolescents. They found similar results--subjects who had a low level of adiponectin also had the condition known as albuminuria--as indicated by high levels of the protein albumin in their urine. Albuminuria is an indicator for kidney disease.

"We found that people with obesity who have low adiponectin levels also have albuminuria," explains lead author Kumar Sharma, M.D., who is also professor of Medicine at Jefferson Medical College of Thomas Jefferson University. "The data also suggest another piece of the puzzle that shows why obese people who have what is known as metabolic syndrome are at risk for, and are dying of, heart disease." The metabolic risk syndrome is a combination of medical disorders that is a risk factor for cardiovascular disease.

"Cardiovascular risk factors that regulate albuminuria in association with the metabolic syndrome have not been established," Dr. Sharma said. "As a next step, we would like to learn how levels of adiponectin become reduced in obese people. Then we can develop the treatments to offset this activity."
-end-
Also contributing to the study are Bonita Falkner, M.D., professor of Medicine and Pediatrics at Jefferson; Barry Goldstein, M.D., Ph.D., professor of Medicine and director, Division of Endocrinology and Metabolic Diseases, Jefferson; Stephen Dunn, assistant professor of Medicine, Division of Nephrology, Jefferson; and Lawrence Chan, M.D., Ph.D., professor of Medicine at Baylor College of Medicine, Houston.

Thomas Jefferson University

Related Heart Disease Articles from Brightsurf:

Cellular pathway of genetic heart disease similar to neurodegenerative disease
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure.

Mechanism linking gum disease to heart disease, other inflammatory conditions discovered
The link between periodontal (gum) disease and other inflammatory conditions such as heart disease and diabetes has long been established, but the mechanism behind that association has, until now, remained a mystery.

New 'atlas' of human heart cells first step toward precision treatments for heart disease
Scientists have for the first time documented all of the different cell types and genes expressed in the healthy human heart, in research published in the journal Nature.

With a heavy heart: How men and women develop heart disease differently
A new study by researchers from McGill University has uncovered that minerals causing aortic heart valve blockage in men and women are different, a discovery that could change how heart disease is diagnosed and treated.

Heart-healthy diets are naturally low in dietary cholesterol and can help to reduce the risk of heart disease and stroke
Eating a heart-healthy dietary pattern rich in vegetables, fruits, whole grains, low-fat dairy products, poultry, fish, legumes, vegetable oils and nuts, which is also limits salt, red and processed meats, refined-carbohydrates and added sugars, is relatively low in dietary cholesterol and supports healthy levels of artery-clogging LDL cholesterol.

Pacemakers can improve heart function in patients with chemotherapy-induced heart disease
Research has shown that treating chemotherapy-induced cardiomyopathy with commercially available cardiac resynchronization therapy (CRT) delivered through a surgically implanted defibrillator or pacemaker can significantly improve patient outcomes.

Arsenic in drinking water may change heart structure raising risk of heart disease
Drinking water that is contaminated with arsenic may lead to thickening of the heart's main pumping chamber in young adults, according to a new study by researchers at Columbia University Mailman School of Public Health.

New health calculator can help predict heart disease risk, estimate heart age
A new online health calculator can help people determine their risk of heart disease, as well as their heart age, accounting for sociodemographic factors such as ethnicity, sense of belonging and education, as well as health status and lifestyle behaviors.

Wide variation in rate of death between VA hospitals for patients with heart disease, heart failure
Death rates for veterans with ischemic heart disease and chronic heart failure varied widely across the Veterans Affairs (VA) health care system from 2010 to 2014, which could suggest differences in the quality of cardiovascular health care provided by VA medical centers.

Heart failure: The Alzheimer's disease of the heart?
Similar to how protein clumps build up in the brain in people with some neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, protein clumps appear to accumulate in the diseased hearts of mice and people with heart failure, according to a team led by Johns Hopkins University researchers.

Read More: Heart Disease News and Heart Disease Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.