Will your epinephrine auto injector still work if it gets frozen?

November 16, 2018

SEATTLE (November 16, 2018) - If you are one of the millions of people in the U.S. who has a severe allergy and carries an epinephrine auto injector (EAI) you may have wondered if it will still work if it gets left in your car in winter and freezes. Turns out it will still work, according to new research being presented at the American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting.

"Since many people who live in cold climates use an EAI, we wanted to explore the effects of freezing on how an EAI functions," says Julie Brown, MD, abstract author. "Lead author and researcher Alex Cooper took 104 same-lot pairs of EAIs and froze one of each pair for 24 hours, while the other was kept at recommended temperatures as a control. Once the frozen devices were thawed, they and their controls were injected into meat. The meat and devices were weighed both before and after firing. The change in meat weight and device weight was similar between frozen-thawed devices and their controls, indicating that freezing did not affect how the EAIs functioned once they were thawed."

Allergists recommend using epinephrine as the first line of defense in treating anaphylaxis. The consequences for not using epinephrine when it is needed are much more severe than using it when it might not be necessary.

"Many people who use EAIs have been concerned about the current shortage of EpiPens," says allergist Anne Ellis, MD, chair of the ACAAI Anaphylaxis Committee. "It's important for those who have severe, life threatening reactions to their allergies to have confidence in the EAIs they carry and know they'll work in an emergency. This study showed that even when an EAI has been unintentionally frozen, the risk is low that it will malfunction."

If you have an EAI that was unintentionally frozen, and you experience an anaphylactic reaction, it's better to use a 'thawed' device than nothing at all. However, you should talk with your allergist about a prescription for a new device.

"The study did not examine the amount of epinephrine remaining in the solution after it had been frozen," says Dr. Ellis. "We know epinephrine is a somewhat unstable compound, and that's why the shelf life of EAIs is so short."

If you have a severe allergy that could result in anaphylaxis, see an allergist. Allergists are trained to help you live the life you want by working with you to treat allergic diseases and avoid severe reactions.
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Abstract Title: The Effects of Freezing on Epinephrine Auto-Injector Device Function

Author: Julie Brown, MD, Alex Cooper

For more information about anaphylaxis and to locate an allergist in your area, visit AllergyandAsthmaRelief.org. The ACAAI Annual Meeting is November 15-19, 2018 at the Washington State Convention Center in Seattle. For more news and research from the ACAAI Scientific Meeting, go to our newsroom - and follow the conversation on Twitter #ACAAI18.

About ACAAI

The ACAAI is a professional medical organization of more than 6,000 allergists-immunologists and allied health professionals, headquartered in Arlington Heights, Ill. The College fosters a culture of collaboration and congeniality in which its members work together and with others toward the common goals of patient care, education, advocacy and research. ACAAI allergists are board-certified physicians trained to diagnose allergies and asthma, administer immunotherapy, and provide patients with the best treatment outcomes. For more information and to find relief, visit AllergyandAsthmaRelief.org. Join us on Facebook, Pinterest and Twitter.

American College of Allergy, Asthma, and Immunology

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