Preventing heart disease should be a priority for people with Type 2 diabetes

November 16, 2020

DALLAS, Nov. 16, 2020 -- Even when risk factors associated with cardiovascular disease are optimally controlled, adults with Type 2 diabetes still have a greater risk of developing cardiovascular disease compared to the general population, according to new research published today in the American Heart Association's flagship journal Circulation.

"Previous studies have shown that people with Type 2 diabetes had little or no excess risk of cardiovascular disease events or death when all risk factors are optimally controlled," said Alison Wright, Ph.D., first author and research associate at the Centre for Pharmacoepidemiology and Drug Safety at the University of Manchester in the United Kingdom. "Our team sought to determine how the degree of risk factor control in people with Type 2 diabetes impacted CVD risk and mortality compared to people with Type 2 diabetes who had all risk factors optimally controlled and to people who do not have Type 2 diabetes."

Researchers analyzed data between 2006 and 2015 using two sources: The Clinical Practice Research Datalink (CPRD) and the Scottish Care Information-Diabetes (SCI-Diabetes) dataset with linkage to hospital and mortality data. More than 101,000 people with Type 2 diabetes were identified and matched with nearly 379,000 people without diabetes in CPRD and nearly 331,000 with Type 2 diabetes in SCI-Diabetes.

Researchers focused on five cardiovascular risk factors: blood pressure, smoking, cholesterol, triglycerides and blood glucose, and examined the association to future cardiovascular events and death among these risk factors that were optimally controlled. Additionally, they examined if the presence of cardiorenal (heart and kidney) disease impacted these connections.

Their analysis found:"People with Type 2 diabetes should be treated for cardiovascular risk factors as early as possible, regardless of whether they have cardiovascular disease or not," Wright said. "There is real potential here to reduce the overall impact of Type 2 diabetes on future cardiovascular events, especially for patients with Type 2 diabetes who have not yet been diagnosed with CVD."

While researchers noted that this research demonstrated the importance of risk factor control overall, future research will explore which individual factors have the greatest impact on cardiovascular risk, and, therefore, are the most important to target with interventions. According to the American Heart Association's Life's Simple 7®, the seven risk factors that people can improve through lifestyle changes to achieve ideal cardiovascular health are managing blood pressure, controlling cholesterol, reducing blood sugar, increasing physical activity, eating healthy foods, losing weight and quitting smoking.

A strength highlighted by the researchers is that the results can also apply to the United States population, as treatment and management guidelines are similar to the UK population studied. A limitation of this study is that it is an observational study, using data from primary care medical records that may be incomplete. Therefore, the data may not provide the full picture of the health status for these patients.
-end-
Co-authors are Milton Fabian Suarez-Ortegon, Ph.D.; Stephanie H. Read, Ph.D.; Evangelos Kontopantelis, Ph.D.; Iain Buchan, M.D.; Richard Emsley, Ph.D.; Naveed Sattar, M.B.Ch.B., Ph.D.; Darren M. Ashcroft, Ph.D.; Sarah H. Wild, Ph.D.; and Martin K. Rutter, M.B.Ch.B., M.D. Author disclosures are in the manuscript.

This study was supported by Diabetes UK.

Additional Resources:

Statements and conclusions of studies published in the American Heart Association's scientific journals are solely those of the study authors and do not necessarily reflect the Association's policy or position. The Association makes no representation or guarantee as to their accuracy or reliability. The Association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific Association programs and events. The Association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and biotech companies, device manufacturers and health insurance providers are available here, and the Association's overall financial information is available here.

About the American Heart Association

The American Heart Association is a relentless force for a world of longer, healthier lives. We are dedicated to ensuring equitable health in all communities. Through collaboration with numerous organizations, and powered by millions of volunteers, we fund innovative research, advocate for the public's health and share lifesaving resources. The Dallas-based organization has been a leading source of health information for nearly a century. Connect with us on heart.org , Facebook , Twitter or by calling 1-800-AHA-USA1.

American Heart Association

Related Diabetes Articles from Brightsurf:

New diabetes medication reduced heart event risk in those with diabetes and kidney disease
Sotagliflozin - a type of medication known as an SGLT2 inhibitor primarily prescribed for Type 2 diabetes - reduces the risk of adverse cardiovascular events for patients with diabetes and kidney disease.

Diabetes drug boosts survival in patients with type 2 diabetes and COVID-19 pneumonia
Sitagliptin, a drug to lower blood sugar in type 2 diabetes, also improves survival in diabetic patients hospitalized with COVID-19, suggests a multicenter observational study in Italy.

Making sense of diabetes
Throughout her 38-year nursing career, Laurel Despins has progressed from a bedside nurse to a clinical nurse specialist and has worked in medical, surgical and cardiac intensive care units.

Helping teens with type 1 diabetes improve diabetes control with MyDiaText
Adolescence is a difficult period of development, made more complex for those with Type 1 diabetes mellitus (T1DM).

Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.

Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).

Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.

People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.

Read More: Diabetes News and Diabetes Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.