Researchers find gene in kidney may play role in high blood pressure in male mice

November 17, 2014

CINCINNATI--Researchers at the University of Cincinnati (UC) have found that a gene abundant in the kidneys may actually play a role in the regulation of blood pressure and hypertension in experimental male mouse models.

The study led by Manoocher Soleimani, MD, James F. Heady Professor of Medicine and associate chair of research in the Department of Internal Medicine at UC, was presented during the annual meeting of the American Society of Nephrology, held Friday, Nov. 15, 2014, in Philadelphia.

The gene, a kidney androgen-regulated protein (KAP) that is abundantly and exclusively found in the kidney proximal tubule, is stimulated by an androgen hormone such as testosterone, says Soleimani.

The function of KAP in the kidney remains unknown, but in an attempt to investigate the gene's role, researchers studied mice developed with a deficiency of the KAP gene. Those mice were compared to a control group of mice.

"The male KAP deficient mice displayed significantly reduced blood pressure," says Soleimani. "Placing the animals on a high salt diet for 14 days led to normalization of blood pressure in the male KAP deficient mice without significantly affecting the control group. These results have significant ramifications."

Soleimani said the results may be helpful in understanding ways to control high blood pressure in humans, specifically in men. About 67 million Americans--or one in every three adults--have high blood pressure, according to the Centers for Disease Control and Prevention.

"It is well known that men are more prone to develop hypertension than women, specifically before the age of 50," says Soleimani. "While this has correlated with higher testosterone levels in men, the exact association between male hormones and hypertension remains unknown. Our results suggests that KAP, which is regulated by testosterone plays an important role in systemic blood pressure in male animals through regulation of salt absorption in the kidney tubule."

"Our findings also nicely explain the historical observations which have demonstrated male sex hormones contribute to the worsening of hypertension."

The research will be presented by Kamyar Zahedi, PhD, from the division of nephrology and hypertension at UC. Other researchers who participated in the study include: Saeed Alshahrani; Marybeth Brooks; Jie Xu and Sharon Barone, all associated with the UC College of Medicine.
-end-
The research was funded by the U.S. Department of Veterans Affairs and the University of Cincinnati.

University of Cincinnati Academic Health Center

Related Blood Pressure Articles from Brightsurf:

Children who take steroids at increased risk for diabetes, high blood pressure, blood clots
Children who take oral steroids to treat asthma or autoimmune diseases have an increased risk of diabetes, high blood pressure, and blood clots, according to Rutgers researchers.

High blood pressure treatment linked to less risk for drop in blood pressure upon standing
Treatment to lower blood pressure did not increase and may decrease the risk of extreme drops in blood pressure upon standing from a sitting position.

Changes in blood pressure control over 2 decades among US adults with high blood pressure
National survey data were used to examine how blood pressure control changed overall among U.S. adults with high blood pressure between 1999-2000 and 2017-2018 and by age, race, insurance type and access to health care.

Transient increase in blood pressure promotes some blood vessel growth
Blood vessels are the body's transportation system, carrying oxygen and nutrients to cells and whisking away waste.

Effect of reducing blood pressure medications on blood pressure control in older adults
Whether the amount of blood pressure medications taken by older adults could be reduced safely and without a significant change in short-term blood pressure control was the objective of this randomized clinical trial that included 534 adults 80 and older.

Brain blood flow sensor discovery could aid treatments for high blood pressure & dementia
A study led by researchers at UCL has discovered the mechanism that allows the brain to monitor its own blood supply, a finding in rats which may help to find new treatments for human conditions including hypertension (high blood pressure) and dementia.

Here's something that will raise your blood pressure
The apelin receptor (APJ) has been presumed to play an important role in the contraction of blood vessels involved in blood pressure regulation.

New strategy for treating high blood pressure
The key to treating blood pressure might lie in people who are 'resistant' to developing high blood pressure even when they eat high salt diets, shows new research published today in Experimental Physiology.

Arm cuff blood pressure measurements may fall short for predicting heart disease risk in some people with resistant high blood pressure
A measurement of central blood pressure in people with difficult-to-treat high blood pressure could help reduce risk of heart disease better than traditional arm cuff readings for some patients, according to preliminary research presented at the American Heart Association's Hypertension 2019 Scientific Sessions.

Heating pads may lower blood pressure in people with high blood pressure when lying down
In people with supine hypertension due to autonomic failure, a condition that increases blood pressure when lying down, overnight heat therapy significantly decreased systolic blood pressure compared to a placebo.

Read More: Blood Pressure News and Blood Pressure Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.