2 studies on the use of breast MRI

November 18, 2013

CHICAGO - The overall use of breast magnetic resonance imaging has increased, with the procedure most commonly used for diagnostic evaluations and screenings, according to a study published by JAMA Internal Medicine, a JAMA Network publication.

While breast MRI is being used increasingly, its sensitivity leads to higher false-positive rates and it is also more expensive. Guidelines from the American Cancer Society (ACS) indicate that breast MRI should be used to screen asymptomatic women at high-risk for breast cancer if they are known carriers of the BRCA gene mutation; first-degree relatives of a known BRCA gene mutation carrier who are themselves untested; or a women with more than a 20 percent lifetime risk of breast cancer, according to the study background.

Karen J. Wernli, Ph.D., of the Group Health Research Institute, Seattle, and colleagues examined the patterns of breast MRI in U.S. community practice from 2005 through 2009 with data collected from five national Breast Cancer Surveillance Consortium registries.

Study results show the overall rate of breast MRI nearly tripled from 4.2 to 11.5 examinations per 1,000 women from 2005 through 2009. The procedure was most commonly used for diagnostic evaluation (40.3 percent), followed by screening (31.7 percent). Women who underwent screening breast MRI were more likely to be younger than 50 years old, white, nulliparous (never had a baby), have a personal history of breast cancer, a family history of breast cancer and extremely dense breast tissue.

Study findings also indicate that the proportion of women screened with breast MRI at high lifetime risk for breast cancer increased from 9 percent in 2005 to 29 percent in 2009. The researchers also note that during the study period, the most common use of breast MRI was for diagnostic evaluation of a non-MRI finding.

"Our findings suggest that there have been improvements in appropriate use of breast MRI, with a smaller proportion of examinations performed for further evaluation of abnormal mammogram results and symptomatic patients, and more breast MRI performed for screening of women at high risk," the authors conclude.

(JAMA Intern Med. Published online November 18, 2013. doi:10.1001/jamainternmed.2013.11963. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: Authors made conflict of interest disclosures. This work was supported by the National Cancer Institute. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Breast MRI Use Increased Then Stabilized Over Past Decade

The use of breast magnetic resonance imaging (MRI) increased in the decade after 2001 before eventually stabilizing, especially for screening and surveillance of women with a family or personal history of breast cancer, according to a study by Natasha K. Stout, Ph.D., of the Harvard Medical School and the Harvard Pilgrim Health Care Institute, Boston, and colleagues.

Although breast MRI is more sensitive than mammography in detecting breast cancer, cost and little evidence regarding the mortality benefits have limited recommendations for its use, the study background notes.

Between 2000 and 2001, researchers studied 10,518 women (ages 20 and older) who were enrolled in a health plan for at least one year and had at least one breast MRI at a multispecialty group medical practice in New England. Breast MRI counts and breast cancer risk status, as well as the reason for testing (screening, diagnostic evaluation, staging or treatment, or surveillance) were obtained.

According to study results, breast MRI increased from 2000 (6.5 examinations per 10,000 women) to 2009 (130.7 exams per 10,000 women), with the greatest increase in use for screening and surveillance. By 2011, use declined then stabilized (104.8 exams per 10,000 women). Screening and surveillance accounted for 57.6 percent of MRI use by 2011. Of the women, 30.1 percent had a claims-document personal history, 51.7 percent a family history of breast cancer, and 3.5 percent of women had a documented genetic mutation.

Researchers noted that in a subset of women with electronic medical records who received screening or surveillance MRIs, only 21 percent had evidence of meeting American Cancer Society criteria for breast MRI. Only 48.4 percent of women with documented genetic mutations received breast MRI screening.

"Understanding who is receiving breast MRI and the downstream consequences of this use should be a high research priority to ensure that the limited health care funds available are used to wisely maximize population health," the authors conclude.

(JAMA Intern Med. Published online November 18, 2013. doi:10.1001/jamainternmed.2013.11958. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: This study was funded by grants from the American Cancer Society and the National Institutes of Health. Please see article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Commentary: Patterns of Breast Magnetic Resonance Imaging use

In a related commentary, E. Shelley Hwang, M.D., M.P.H., of the Duke University Medical Center, Durham, N.C., and Isabelle Bedrosian, M.D., of the MD Anderson Cancer Center, Houston, write: "In an era of ever-increasing focus on cost containment in health care, the value of MRI is clearly an issue of concern."

"What is striking in both studies by Wernli et al and Stout et al was that breast MRI was both overused in women not meeting guideline criteria and underused in those who could derive greatest benefit," they continue.

"As a medical community, we bear a collective responsibility to ensure that breast MRI provides sufficient clinical benefit to warrant the additional biopsies, increased patient anxiety and cost that accrue with its use," they conclude.

(JAMA Intern Med. Published online November 18, 2013. doi:10.1001/jamainternmed.2013.10502. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
-end-
Media Advisory: To contact author Karen J. Wernli, Ph.D., call Rebecca Hughes at 206-287-2055 or email hughes.r@ghc.org. To contact author Natasha K. Stout, Ph.D., call Mary Wallan at 617-509-2419. or email mary_wallan@harvardpilgrim.org. To contact commentary author E. Shelley Hwang, M.D., M.P.H., call Rachel Harrison at 919-419-5069 or email rachel.harrison@duke.edu.

The JAMA Network Journals

Related Breast Cancer Articles from Brightsurf:

Oncotarget: IGF2 expression in breast cancer tumors and in breast cancer cells
The Oncotarget authors propose that methylation of DVDMR represents a novel epigenetic biomarker that determines the levels of IGF2 protein expression in breast cancer.

Breast cancer: AI predicts which pre-malignant breast lesions will progress to advanced cancer
New research at Case Western Reserve University in Cleveland, Ohio, could help better determine which patients diagnosed with the pre-malignant breast cancer commonly as stage 0 are likely to progress to invasive breast cancer and therefore might benefit from additional therapy over and above surgery alone.

Partial breast irradiation effective treatment option for low-risk breast cancer
Partial breast irradiation produces similar long-term survival rates and risk for recurrence compared with whole breast irradiation for many women with low-risk, early stage breast cancer, according to new clinical data from a national clinical trial involving researchers from The Ohio State University Comprehensive Cancer Center - Arthur G.

Breast screening linked to 60 per cent lower risk of breast cancer death in first 10 years
Women who take part in breast screening have a significantly greater benefit from treatments than those who are not screened, according to a study of more than 50,000 women.

More clues revealed in link between normal breast changes and invasive breast cancer
A research team, led by investigators from Georgetown Lombardi Comprehensive Cancer Center, details how a natural and dramatic process -- changes in mammary glands to accommodate breastfeeding -- uses a molecular process believed to contribute to survival of pre-malignant breast cells.

Breast tissue tumor suppressor PTEN: A potential Achilles heel for breast cancer cells
A highly collaborative team of researchers at the Medical University of South Carolina and Ohio State University report in Nature Communications that they have identified a novel pathway for connective tissue PTEN in breast cancer cell response to radiotherapy.

Computers equal radiologists in assessing breast density and associated breast cancer risk
Automated breast-density evaluation was just as accurate in predicting women's risk of breast cancer, found and not found by mammography, as subjective evaluation done by radiologists, in a study led by researchers at UC San Francisco and Mayo Clinic.

Blood test can effectively rule out breast cancer, regardless of breast density
A new study published in PLOS ONE demonstrates that Videssa® Breast, a multi-protein biomarker blood test for breast cancer, is unaffected by breast density and can reliably rule out breast cancer in women with both dense and non-dense breast tissue.

Study shows influence of surgeons on likelihood of removal of healthy breast after breast cancer dia
Attending surgeons can have a strong influence on whether a patient undergoes contralateral prophylactic mastectomy after a diagnosis of breast cancer, according to a study published by JAMA Surgery.

Young breast cancer patients undergoing breast conserving surgery see improved prognosis
A new analysis indicates that breast cancer prognoses have improved over time in young women treated with breast conserving surgery.

Read More: Breast Cancer News and Breast Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.