Reflux and ulcer medications linked to kidney stones and chronic kidney diseaseNovember 18, 2016
- Individuals who took proton pump inhibitors or histamine receptor-2 blockers for heartburn, acid re?ux, or ulcers had elevated risks of developing kidney stones.
- In individuals without acute kidney injury, proton pump inhibitors were linked with a higher risk of developing chronic kidney disease or kidney failure compared with histamine receptor-2 blockers.
- Research that uncovered these findings will be presented at ASN Kidney Week 2016 November 15-20 at McCormick Place in Chicago, IL.
Proton pump inhibitors (PPIs) and histamine receptor-2 (H2) blockers are commonly used to reduce gastric acid production. To see if these drugs increase the risk of developing kidney stones, Pietro Manuel Ferraro, MD, MS, PhD (Fondazione Policlinico Universitario A. Gemelli - Catholic University of the Sacred Heart, in Rome, Italy) and his colleagues examined information on 187,330 participants of the Health Professionals Follow-up Study (HPFS) and Nurses' Health Study (NHS) I and II who were initially free of kidney stones.
During a follow-up of up to 12 years for PPIs and 26 years for H2 blockers, 3245 symptomatic kidney stones developed. After adjusting for a number of factors such as age, race, body mass index, physical activity, smoking status, comorbidities, use of medications, and intake of nutrients, use of PPIs was associated with a 12% higher risk of developing a kidney stone, and use of H2 blockers with a 13% higher risk. In a subgroup of participants, use of PPIs was associated with lower urinary excretion of calcium, oxalate, citrate, and magnesium, which are components of kidney stones.
"Use of PPIs and H2 blockers is associated with a small increase in risk of incident kidney stones. Further studies are needed to confirm our findings and to investigate whether the excess risk is related to a particular type of kidney stones such as those made of calcium oxalate," said Dr. Ferraro.
In a second study, Yan Xie, MPH (VA Saint Louis Health Care System) and his colleagues examined current assumptions that chronic kidney disease that may arise after use of PPIs is secondary to incomplete recovery from acute kidney injury (AKI). When the investigators analyzed information in the Department of Veterans Affairs national database on 152,157 users of PPIs or H2 blockers, PPI use was associated with a greater than 30% higher risk of developing CKD or a combined endpoint of kidney failure or more than 50% decline in estimated glomerular filtration rate (a measure of kidney function) compared with H2 blocker use in the absence of AKI.
"Reliance on AKI as a marker of potential adverse renal events in those treated with PPI is not sufficient," said Xie "Exercising vigilance in PPI use--even in the absence of AKI--and careful attention to kidney function in PPI users may be a reasonable approach."
ASN Kidney Week 2016, the largest nephrology meeting of its kind, will provide a forum for more than 13,000 professionals to discuss the latest findings in kidney health research and engage in educational sessions related to advances in the care of patients with kidney and related disorders. Kidney Week 2016 will take place November 15-20, 2016 in Chicago, IL.
The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.
Since 1966, ASN has been leading the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients. ASN has nearly 16,000 members representing 112 countries. For more information, please visit http://www.asn-online.org or contact us at (202) 640-4660.
American Society of Nephrology
Related Chronic Kidney Disease Articles:
A University of Delaware research team is combating chronic kidney disease (CKD) with exercise.
A Massachusetts General Hospital research team has developed a way to avoid ischemia/reperfusion injury of the kidney with a new monoclonal antibody that binds its target receptor in a way that is 'just right.'
Individuals who took proton pump inhibitors or histamine receptor-2 blockers for heartburn, acid reflux, or ulcers had elevated risks of developing kidney stones.
Allopurinol, a widely used treatment for lowering serum urate levels, does not appear to increase risk of kidney deterioration in gout patients with normal or near-normal kidney function, according to new research findings presented this week at the 2016 ACR/ARHP Annual Meeting in Washington.
Mayo Clinic nephrologists have uncovered a connection between first-time kidney stone formers and chronic kidney disease.
A team from the University of Montreal Hospital Research Centre (CRCHUM) has discovered a novel link between chronic kidney disease and diabetes.
In this issue of the JCI, researchers at the University of Montreal demonstrated that high levels of urea may compromise the function of insulin-producing pancreas cells and lead to impaired blood sugar regulation in chronic kidney disease.
Currently, there is no effective method to predict the prognosis of chronic kidney disease (CKD) patients.
Two-thirds of the children with kidney disease were classified as vitamin D deficient.
Kidney function remained unchanged among hypertensive adults in communities assigned to a public health intervention for general practitioners and community health workers, whereas kidney function significantly declined among those who received usual care.
Related Chronic Kidney Disease Reading:
The Doctor's Kidney Diets: A Nutritional Guide to Managing and Slowing the Progression of Chronic Kidney Disease
by Mandip S. Kang MD (Author)
* Winner of the IBPA Benjamin Franklin Award for Best Health title
In the United States alone, 26 million adults have chronic kidney disease (CKD), and experts project that over half the country may develop CKD due to rising rates of disorders such as diabetes. While nephrologists can monitor kidney function and treat patients with medications, they can’t always offer the nutritional guidance that every kidney patient requires. To fill this information gap, Dr. Mandip Kang has written The Doctor’s Kidney Diets, a comprehensive guide to managing,... View Details
Renal Diet Cookbook for the Newly Diagnosed: The Complete Guide to Managing Kidney Disease and Avoiding Dialysis
by Susan Zogheib MHS RD LDN (Author), Jay Wish MD (Foreword)
Kick-start a kidney-healthy life with a 30-day meal plan from the author of the bestselling Renal Diet Cookbook
Figuring out what you can and cannot eat when you or someone you care for is diagnosed with stage 1-4 chronic kidney disease (CKD) is overwhelming. No one understands this more than Susan Zogheib, a registered dietitian and leader in the field of renal nutrition, who lays out an easy 30-day meal plan for a kidney-healthy diet and lifestyle. The Renal Diet Cookbook for the Newly Diagnosed is an action-based plan that equips you with weekly... View Details
Renal Diet Cookbook: The Low Sodium, Low Potassium, Healthy Kidney Cookbook
by Susan Zogheib (Author), John Wigneswaran (Author)
"Susan has done a masterful job in educating patients about their disease, explaining why watching your diet is important, and offering meal plans and recipes that encourage compliance and fun."— John Wigneswaran, MD, VP Clinical Affairs DaVita Healthcare Partners
While a kidney disease diagnosis can be overwhelming, you're not alone. Nearly 26 million adults are affected by chronic kidney disease, but there is hope: your diet. In the Renal Diet Cookbook, renal dietician Susan Zogheib, MHS, RD, LDN provides a 28-day plan to establish long-term dietary... View Details
What Is It and How Did I Get It?: Early Stage Chronic Kidney Disease
by Gail Rae (Author)
What Is It and How Did I Get It? Early Stage Chronic Kidney Disease explains to the newly diagnosed CKD patient and others the medical terms and information, and the overwhelming task of trying to understand all this at once. It covers the initial suspicion of the disease and the necessary tests to verify that suspicion. The book also tells about doctors' visits, what to expect, how to deal with them and what to do when you're missing half the information you're being given. Renal nutrition, the need for exercise, and what friends and family need to know are also included. In addition, there... View Details
Chronic Kidney Disease: A practical guide to understanding and management (Oxford Clinical Nephrology Series)
by Meguid El Nahas (Author), Adeera Levin (Author)
Chronic Kidney Disease (CKD) is rapidly becoming a global healthcare problem with an estimated 10% of the general population affected. As a result, it is becoming increasingly important that primary care physicians and general physic, as well as aspiring nephrologists, have a firm understanding of CKD as well as access to the key information.
Practical and highly-accessible, this book provides a comprehensive guide to the understanding and management of patients with CKD. It offers both primary care physicians and non-nephrology specialists an introduction to and insights into the... View Details
Chronic Kidney Disease: For Beginners! - Learn Everything You Need To Know About Chronic Kidney Disease Detection, Prevention, Treatment And Diet! ... Disease, KIdney Stones, Kidney Disease 101)
by Adam Johnson (Author)
Chronic Kidney Disease For Beginners! - Learn Everything You Need To Know About Chronic Kidney Disease Detection, Prevention, Treatment And Diet! Do you want to know about chronic kidney infection? Chronic kidney infection is a condition that predates kidney failure. It’s not something you want to deal with, but it’s important to know the symptoms and conditions that come with this. For some, they might be minor, but others they might be severe. This book will go over everything you need to know about chronic kidney disease. By the end of this, you’ll know how to diagnose, the... View Details
Chronic Kidney Disease: The Essential Guide To CKD - Learn Everything You Need To Know About Chronic Kidney Disease (Chronic Kidney Disease, Kidney Stones, CKD)
by Susie Thompson (Author)
Chronic Kidney Disease The Essential Guide To CKD - Learn Everything You Need To Know About Chronic Kidney Disease Chronic kidney disease affects 26 million adults; it is a disease that causes measured loss of kidney function over time. The best way to deal with any disease is to learn all you can and become an active participant in your care or the care of loved ones. When you are active in your own care or the care of loved ones, treatment is more effective because you understand the condition and its effects on the body. If you are waiting for a kidney transplant, receiving... View Details
Coping with Kidney Disease: A 12-Step Treatment Program to Help You Avoid Dialysis
by Mackenzie Walser (Author), Betsy Thorpe (Author)
A revolutionary program that can indefinitely postpone the need for dialysis
If you've been diagnosed with kidney failure, this book could save your life. If you suffer from diabetes, hypertension, obesity, or any of a host of conditions that put you at risk for kidney disease, you owe it to yourself to read what is in this book. If you are among the 60,000 North Americans who go on dialysis each year, the information in this book could substantially improve your quality of life.
In Coping with Kidney Disease, a leading expert tells you, in plain English, what you... View Details
Smoothies for Kidney Health: A Delicious Approach to the Prevention and Management of Kidney Problems & So Much More
by Victoria L. Hulett JD JD (Author), Jennifer L. Waybright RN (Author)
Smoothies for Kidney Health is a very special recipe book. It is expertly put together by a kidney donor, who is a registered nurse, and her mom, the recipient of her kidney. Together, they have taken their knowledge and experience to create a resource for all those suffering from chronic kidney disease (CKD). By explaining how kidney function is impacted by the foods we eat, they offer a simple way for patients to help slow down, stop, or possibly reverse the many effects of CKD―including heart disease, the number one killer of kidney patients. The vital... View Details
Chronic Kidney Disease: The Ultimate CKD Cookbook - Amazing Healthy Meals To Manage Your Kidney Disease! (Chronic Kidney Disease, KIdney Stones, Kidney Disease 101)
by Elizabeth Logan (Author)
Chronic Kidney Disease The Ultimate CKD Cookbook - Amazing Healthy Meals To Manage Your Kidney Disease! Chronic kidney disease can be a very intimidating thing to be diagnosed with. But if you know how to take care of yourself and your body, then you’re going to be just fine. When chronic kidney disease becomes a part of your life, there are certain changes that you’re going to need to make before you’re able to say you’re doing all that you can to avoid a miserable existence. Everybody deserves to be happy and healthy, but when CKD becomes a part of our lives, we have to take some... View Details