Bedtime aspirin may reduce risk of morning heart attack

November 19, 2013

Taking aspirin at bedtime instead of in the morning might reduce acute heart events, according a new study presented at the American Heart Association's Scientific Sessions 2013.

Low-dose daily aspirin is recommended for people at high risk of heart disease and for reducing the risk of recurrent heart events. Aspirin thins the blood and makes it less likely to clot. The tendency for platelet activity to be higher peaks in the morning.

The Aspirin in Reduction of Tension II trial is the first study to explore the timing of aspirin intake among cardiovascular disease patients. In the randomized, open-label study, 290 patients took either 100 mg of aspirin upon waking or at bedtime during two 3-month periods. At the end of each period, blood pressure and platelet activity was measured.

Blood pressure was not reduced; however, bedtime aspirin platelet activity was reduced by 22 units (aspirin reaction units).

"Because higher platelet activity contributes to a higher risk of acute heart events, this simple intervention - switching aspirin intake from morning to bedtime - could be beneficial for the millions of patients with heart disease who take aspirin on a daily basis," said Tobias Bonten, M.D., Ph.D student at the Leiden University Medical Center in the Netherlands.
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Note: Actual presentation is 3:45 p.m. CT/4:45p.m. ET Tuesday, Nov. 19, 2013.

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Additional resources related to these tips are on the right column of the release link at http://newsroom.heart.org/news/tuesday-news-tips?preview=b2873852502cdfc35fa2339bd73262ee.

NOTE: ALL TIMES ARE CENTRAL. ALL TIPS ARE EMBARGOED UNTIL THE TIME OF PRESENTATION OR 3 P.M. CT/4 PM ET EACH DAY, WHICHEVER COMES FIRST. For more information Nov. 16-20, call the AHA News Media Staff Office in the Dallas Convention Center at (214) 853-8008. Before or after these dates, call the Communications Office in Dallas at (214) 706-1173. For public inquiries, call (800) AHA-USA1 (242-8721).

American Heart Association

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