Insights on a mechanism to stop COVID-19 replication

November 19, 2020

Stopping the replication of SARS-CoV-2 is likely possible thanks to a compound called EBSELEN: a group of researchers from the Politecnico di Milano has communicated aspects relevant to the blocking of replication mechanism in the New Journal of Chemistry.

Two important aspects of the propagation of a virus are its ability to enter the host's cells, that is, to infect the host, and then to replicate in infected cells.

As for SARS-CoV-2, the Mpro protein plays an important role in the replication and transcription of the virus. Mpro therefore represents a particularly promising target for blocking the virus itself because a compound that inhibits Mpro blocks the virus.

EBSELEN proved to be the most potent inhibitor of Mpro in a study examining approximately 10,000 selected compounds. In their study, the researchers at Politecnico elucidate key aspects of the Mpro blocking mechanism by EBSELEN.

"We have identified that the selenium atom of EBSELEN strongly interacts with some groups typically present in proteins via the chalcogen bond, a weak bonding that has been studied for years in our laboratories; this binding may contribute to the inhibition of the virus replication. This represents an important step forward in the fight against COVID-19. " Says Prof. Giuseppe Resnati of the Department of Chemistry, Materials and Chemical Engineering "Giulio Natta" of the Politecnico di Milano.

The article clarifies the details of the EBSELEN / enzyme binding mechanism. It is shown that selenium plays a fundamental role in establishing the interactions that favor the binding of EBSELEN to SARS-CoV-2 and to other pathogenic retroviruses in humans such as those of HIV and Hepatitis C.
-end-


Politecnico di Milano

Related Virus Articles from Brightsurf:

Researchers develop virus live stream to study virus infection
Researchers from the Hubrecht Institute and Utrecht University developed an advanced technique that makes it possible to monitor a virus infection live.

Will the COVID-19 virus become endemic?
A new article in the journal Science by Columbia Mailman School researchers Jeffrey Shaman and Marta Galanti explores the potential for the COVID-19 virus to become endemic, a regular feature producing recurring outbreaks in humans.

Smart virus
HSE University researchers have found microRNA molecules that are potentially capable of repressing the replication of human coronaviruses, including SARS-CoV-2.

COVID-19 - The virus and the vasculature
In severe cases of COVID-19, the infection can lead to obstruction of the blood vessels in the lung, heart and kidneys.

Lab-made virus mimics COVID-19 virus
Researchers at Washington University School of Medicine in St. Louis have created a virus in the lab that infects cells and interacts with antibodies just like the COVID-19 virus, but lacks the ability to cause severe disease.

Virus prevalence associated with habitat
Levels of virus infection in lobsters seem to be related to habitat and other species, new studies of Caribbean marine protected areas have shown.

Herpes virus decoded
The genome of the herpes simplex virus 1 was decoded using new methods.

A new biosensor for the COVID-19 virus
A team of researchers from Empa, ETH Zurich and Zurich University Hospital has succeeded in developing a novel sensor for detecting the new coronavirus.

How at risk are you of getting a virus on an airplane?
New 'CALM' model on passenger movement developed using Frontera supercomputer.

Virus multiplication in 3D
Vaccinia viruses serve as a vaccine against human smallpox and as the basis of new cancer therapies.

Read More: Virus News and Virus Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.