Antimicrobial peptides with anticancer properties

November 19, 2020

Announcing a new article publication for BIO Integration journal. In this article the authors Zhong, Cuiyu; Zhang, Lei; Huang, Jiandong; Huang, Songyin; Yao, Yandan from Sun Yat-sen University, Guangzhou, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China and Shenzhen Institutes of Advanced Technology, Guangdong, China review antimicrobial peptides with anticancer properties.

There is considerable interest in a new class of anticancer molecules that is currently still under investigation termed the cationic antimicrobial peptides (AMPs). AMPs are a group of pervasive components of the innate immunity which can be found throughout all classes of life. The small innate peptides cover a broad spectrum of antibacterial activities due to their electrostatic interactions with the negatively charged bacterial membrane.

Compared with normal cells, cancer cells have increased proportions of negatively charged molecules, including phosphatidylserine, glycoproteins, and glycolipids, on the outer plasma membrane. This provides an opportunity for exploiting the interaction between AMPs and negatively charged cell membranes in developing unconventional anticancer strategies. Some AMPs may also be categorized into a group of potential anticancer agents called cationic anticancer peptides (ACPs) due to their relative selectivity in cell membrane penetration and lysis, which is similar to their interaction with bacterial membranes.

The authors review several examples of ACPs that are used in tumor therapy for their ability in penetrating or lysing tumor cell membrane and discuss recent advances and challenges in the application of ACPs.
-end-
Article reference: Authors: Zhong, Cuiyu; Zhang, Lei; Huang, Jiandong; Huang, Songyin; Yao, Yandan, Review for Antimicrobial Peptides with Anticancer Properties: Re-purposing of Potential Anticancer Agents, BIO Integration, 2020, https://doi.org/10.15212/bioi-2020-0013

BIO Integration is fully open access journal which will allow for the rapid dissemination of multidisciplinary views driving the progress of modern medicine.

As part of its mandate to help bring interesting work and knowledge from around the world to a wider audience, BIOI will actively support authors through open access publishing and through waiving author fees in its first years. Also, publication support for authors whose first language is not English will be offered in areas such as manuscript development, English language editing and artwork assistance.

BIOI is now open for submissions; articles can be submitted online at:

https://mc04.manuscriptcentral.com/bioi

Please visit http://www.bio-integration.org to learn more about the journal.

Editorial Board: https://bio-integration.org/editorial-board/

BIOI is available on the IngentaConnect platform (https://www.ingentaconnect.com/content/cscript/bioi) and at the BIO Integration website (http://www.bio-integration.org).

Submissions may be made using ScholarOne (https://mc04.manuscriptcentral.com/bioi).

There are no author submission or article processing fees.

Follow BIOI on Twitter @JournalBio; Facebook and LinkedIn.

ISSN 2712-0074

eISSN 2712-0082

Keywords: Anticancer activity, anticancer peptide, antimicrobial peptide, electrostatic interaction, membrane, nanosystems

Compuscript Ltd

Related China Articles from Brightsurf:

China 2050: How the US should prepare for an ascendant China -- RAND Report
New RAND report says US should prepare for a triumphant or ascending People's Republic of China -- scenarios that not only align with current PRC national development trends but also represent the most challenging future scenarios for the US military.

The GDP fudge: China edition
By linking GDP growth to promotions, the Chinese government has inadvertently created incentives for provincial officials to report inaccurate financial data, a study says.

Opportunity blows for offshore wind in China
If China is to meet and exceed its Paris Climate Agreement goal by 2030, it's going to need to find a way to increase its wind capacity.

Cesarean delivery rates in China
This study assessed changes between 2008 and 2018 in the rate of cesarean deliveries in China.

Environmental pollution in China begins decreasing
For decades pollution in China has paralleled economic growth. But this connection has been weakened in recent years, according to a new international research study published in the Science Advances journal.

Farming for natural profits in China
Expanding monoculture threatens valuable services from land, such as flood control, water purification and climate stabilization.

Cardiovascular disease in China
This study analyzed data from the Global Burden of Disease Study to look at the rate of cardiovascular disease (CVD) in China along with death and disability from CVD from 1990 to 2016.

New integrative stratigraphy and timescale for China released
A special issue, edited by professor SHEN Shuzhong and professor RONG Jiayu of the Nanjing Institute of Geology and Palaeontology of the Chinese Academy of Sciences, summarizes the latest advances in stratigraphy and timescale as well as discusses the correlation among different blocks in China and with international timescales.

Cambrian integrative stratigraphy and timescale of China
The review paper briefly summarizes the historical narrative of the present international chronostratigraphic framework of the Cambrian System and recent advances and problems of the undefined Cambrian stage GSSPs, in particular the authors challenge the global correlation of the GSSP for the Cambrian base, in addition to Cambrian chemostratigraphy and geochronology.

What causes extreme heat in North China?
A collaborative research team from China has published a new analysis that shows the horizontal heat flux in the mixed layer plays a crucial role in extreme heat events in the North China Plain region.

Read More: China News and China Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.