Cesarean-born babies at increased risk of infection-related hospitalisation in childhood

November 19, 2020

Cesarean-born babies are at increased risk during early childhood of being hospitalised due to an infection, according to a new study of over seven million births from four countries.

The study, led by the Murdoch Children's Research Institute (MCRI) and Aarhus University and published in PLOS Medicine, found a small but consistent increase in the absolute risk of infection-related hospitalisation rates in children up to five years of age compared with vaginally-born children.

Study lead author MCRI's Dr Jessica Miller said because infection was the leading cause of children being admitted to hospital, any measures to reduce infection rates would make a measurable and lasting difference to the overall health of populations.

The study of 7.2 million births from Australia, Denmark, Scotland and England recorded 23 per cent by cesarean and of these, 57 per cent were emergency cesareans. Cesarean rates varied significantly between the countries.

Overall, about 1.5 million children in the study were hospitalised with an infection before their fifth birthday. About 14,000 of these infections may be attributed to being born by emergency cesarean and 18,500 to pre-labour cesarean.

Increased infection risks lasted until five years of age and were highest for respiratory, gastrointestinal and other viral infections.

Dr Miller said prior to this study, the questions of whether a cesarean birth was associated with increased risk of any infection or only certain types of infection, and if the risk was different for emergency versus pre-labour cesarean had remained unclear.

Study co-lead senior author Aarhus University's Professor Lars Pedersen said despite the small increased risk of childhood infections, cesarean births may be the safest option for some women and babies.

Professor Pedersen said the link between cesarean birth and infection could reflect differences in early microbial exposure (bacteria from the mother's vagina) during delivery.

"During vaginal birth, the baby comes into contact with normal bacteria from the mother's gut and vagina. Babies born by cesarean section have much less exposure to these bacteria," he said.

Study co-lead senior author MCRI's Professor David Burgner said cesarean births were suggested to have short and long-term health implications for children including increased risk of asthma, allergy, juvenile idiopathic arthritis and inflammatory bowel disease.

"Differences in microbial exposure due to birth mode, which can persist for months or possibly years, may contribute to the increased risk of infection-related hospitalisation following a cesarean birth," he said.

"Our microbiomes can affect the development of postnatal immune responses, including to infection. The microbiome can also be optimised by postnatal factors, such as breast-feeding and early skin-to-skin contact after birth."

Global cesarean rates have almost doubled since 2000, with about 6.2 million non-medically indicated caesareans performed worldwide each year.

"Our findings have implications for clinical practice and public health policy," Professor Burgner said. "Infection is the leading cause of early childhood hospitalisation and these findings should lead to studies to understand the mechanisms, including the effects of birth mode on immune development, and whether simple interventions, such as increasing breast-feeding rates, can offset any increased risks.

"It will be important to investigate whether similar findings are seen in low and middle income countries, where the burden of childhood infection is likely to be much higher."

Researchers from the University of Melbourne, University of Oxford, Telethon Kids Institute, University of Sydney, NHS National Services Scotland, and the University of Western Australia also contributed to the study.

Jessica E. Miller, Raphael Goldacre, Hannah C. Moore, Justin Zeltzer, Marian Knight, Carole Morris, Sian Nowell, Rachael Wood, Kim W. Carter, Parveen Fathima, Nicholas de Klerk, Tobias Strunk, Jiong Li, Natasha Nassar, Lars H. Pedersen and David P. Burgner. 'Mode Of Birth And Risk Of Infection Related Hospitalisation In Childhood: A Population Cohort Study Of 7.17 Million Births From Four High-Income Countries,' PLOS Medicine.
DOI: 10.1371/journal.pmed.1003429

*The content of this communication is the sole responsibility of MCRI and does not reflect the views of the NHMRC.

Available for interview:

Professor David Burger, MCRI Group Leader
Inflammatory Origins

Associate Professor Lisa Hui, MCRI Team Leader
Reproductive Epidemiology

Professor Lars Pedersen, Aarhus University

Murdoch Childrens Research Institute

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