New guidance for cluster randomized trials

November 20, 2012

In this week's PLOS Medicine, Charles Weijer and colleagues present the Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials, which aims to provide researchers and research ethics committees with detailed guidance on the ethical design, conduct, and review of CRTs.
-end-
Funding: This work was supported by the Canadian Institutes of Health Research (grant numbers MOP85066, MOP89790). CW and JMG hold Tier I Canada Research Chairs. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Members of the Ottawa Ethics of Cluster Randomized Trials Consensus Group participated in this project as individuals and not as representatives of their employers. Authorship does not imply the approval of this document by the authors' employers or other organizations with which they are affiliated.

Competing Interests: The authors have declared that no competing interests exist.

Citation: Weijer C, Grimshaw JM, Eccles MP, McRae AD, White A, et al. (2012) The Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials. PLoS Med 9(11): e1001346. doi:10.1371/journal.pmed.1001346

IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER (THIS LINK WILL BECOME LIVE WHEN THE EMBARGO LIFTS):

http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001346

CONTACT:Charles Weijer
Rotman Institute of Philosophy
Department of Philosophy
Western University, London, Ontario, Canada,
cweijer@uwo.ca

PLOS

Related Aims Articles from Brightsurf:

Face mask aims to deactivate virus to protect others
Researchers have developed a face mask with an embedded antiviral layer that sanitizes the wearer's respiratory droplets to make them less infectious to others.

New algorithm aims to protect surgical team members against infection with COVID-19 virus
Researchers have created an algorithm that aims to protect operating room team members who perform urgent and emergency operations from COVID-19.

Breastfeeding guide aims to help docs ease moms through tough 1st week
The guide aims to address gaps in knowledge and support created in previous decades when breastfeeding was far less common.

New guideline aims to transform evaluation and care of children and adolescents with ADHD
The Journal of Developmental & Behavioral Pediatrics is releasing a groundbreaking guideline for the diagnosis and care of attention-deficit/hyperactivity disorders in children and youth in a supplement to its February 2020 issue.

Updated Barrett's Guideline aims to improve patient outcomes
The American Society for Gastrointestinal Endoscopy (ASGE) has released its updated 'ASGE guideline on screening and surveillance of Barrett's esophagus,' published in the September issue of GIE: Gastrointestinal Endoscopy.

A new theory for trapping light particles aims to advance development of quantum computers
Researchers have developed a new protocol for ensuring the stability of data when photons are stored for extended periods of time.

New study aims to validate pediatric version of sequential organ failure assessment
A new study aims to validate the pediatric version of Sequential Organ Failure Assessment score in the emergency department setting as a predictor of mortality in all patients and patients with suspected infection.

New study aims to improve outcomes for pregnancies impacted by opioid use disorder
A new study aims to actively involve birthing hospitals to improve health and social outcomes for the maternal infant dyads impacted by Opioid Use Disorder (OUD).

Conservationists clash over ways forward despite sharing 'core aims', study finds
Latest research reveals rifts within global conservation movement while confirming support for aims underpinning it.

New World Health Organization strategy aims to halve the global impact of snakebite
New strategy aims to ensure safe, effective and affordable treatment for all; empower communities at all levels to take proactive action; strengthen health systems to deliver better outcomes; build a global coalition of partners to coordinate action and mobilise resources.

Read More: Aims News and Aims Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.