Nav: Home

NeuroExpresso: Web app enables exploration of brain cell types

November 20, 2017

An online database of gene expression profiles for 36 major types of brain cells from 12 brain regions, based on mouse data from multiple laboratories, is reported in a new paper published in eNeuro. The tool is provided as a resource for neuroscientists at http://neuroexpresso.org/ and will be presented on Wednesday November 15 at Neuroscience 2017, the annual meeting of the Society for Neuroscience.

Brain cells can be described in many different ways depending on qualities such as location, electrical properties and the neurotransmitters they release. Identifying specific marker genes that are expressed by cells straddling these classifications can help to better define their functions and properties, which is necessary to understand their role in neurological disorders.

Paul Pavlidis and colleagues reanalyzed previously published data to create a comprehensive catalogue of brain cell type data in a web-based application called NeuroExpresso. The authors used the data to identify marker genes, which can be used to estimate cellular composition of mouse and human tissue using marker gene profiles. They demonstrate the agreement of their approach with experimental results from studies of human brain disorders including Parkinson's disease. An early version of NeuroExpresso has been used to interpret gene expression in the brains of suicide victims.
-end-
Article: Cross-Laboratory Analysis of Brain Cell Type Transcriptomes with Applications to Interpretation of Bulk Tissue Data

DOI: https://doi.org/10.1523/ENEURO.0212-17.2017 Corresponding author: Paul Pavlidis (University of British Columbia, Vancouver, Canada), paul@msl.ubc.ca

About eNeuro

eNeuro, the Society for Neuroscience's new open-access journal launched in 2014, publishes rigorous neuroscience research with double-blind peer review that masks the identity of both the authors and reviewers, minimizing the potential for implicit biases. eNeuro is distinguished by a broader scope and balanced perspective achieved by publishing negative results, failure to replicate or replication studies. New research, computational neuroscience, theories and methods are also published.

About The Society for Neuroscience

The Society for Neuroscience is the world's largest organization of scientists and physicians devoted to understanding the brain and nervous system. The nonprofit organization, founded in 1969, now has nearly 37,000 members in more than 90 countries and over 130 chapters worldwide

Society for Neuroscience

Related Brain Cells Articles:

Mapping immune cells in brain tumors
It is not always possible to completely remove malignant brain tumors by surgery so that further treatment is necessary.
Zika virus' key into brain cells ID'd, leveraged to block infection and kill cancer cells
Two different UC San Diego research teams identified the same molecule -- αvβ5 integrin -- as Zika virus' key to brain cell entry.
Transplanting human nerve cells into a mouse brain reveals how they wire into brain circuits
A team of researchers led by Pierre Vanderhaeghen and Vincent Bonin (VIB-KU Leuven, Université libre de Bruxelles and NERF) showed how human nerve cells can develop at their own pace, and form highly precise connections with the surrounding mouse brain cells.
Manipulating brain cells by smartphone
Researchers have developed a soft neural implant that can be wirelessly controlled using a smartphone.
How brain cells pick which connections to keep
A new study shows that the protein CPG15 acts as a molecular proxy of experience to mark synapses for stabilization, a key step in ensuring brain circuits can be refined by experience for optimal functional efficiency.
Dormant neural stem cells in fruit flies activate to generate new brain cells
Researchers in Singapore have discovered the mechanism behind how neural stem cells in fruit flies are activated to stimulate the generation of new brain cells.
The development of brain stem cells into new nerve cells and why this can lead to cancer
Stem cells are true Jacks-of-all-trades of our bodies, as they can turn into the many different cell types of all organs.
Watching brain cells fire
Brain scientists have plenty of ways to track the activity of individual neurons in the brain, but they're all invasive.
How glial cells develop in the brain from neural precursor cells
A Mainz-based research team studied how glial cells develop in the brain from neural precursor cells.
'Chemo brain' caused by malfunction in three types of brain cells, Stanford study finds
In a new study explaining the cellular mechanisms behind cognitive impairment from chemotherapy, scientists at the Stanford University School of Medicine have demonstrated that a widely used chemotherapy drug, methotrexate, causes a complex set of problems in three major cell types within the brain's white matter.
More Brain Cells News and Brain Cells Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Making Amends
What makes a true apology? What does it mean to make amends for past mistakes? This hour, TED speakers explore how repairing the wrongs of the past is the first step toward healing for the future. Guests include historian and preservationist Brent Leggs, law professor Martha Minow, librarian Dawn Wacek, and playwright V (formerly Eve Ensler).
Now Playing: Science for the People

#566 Is Your Gut Leaking?
This week we're busting the human gut wide open with Dr. Alessio Fasano from the Center for Celiac Research and Treatment at Massachusetts General Hospital. Join host Anika Hazra for our discussion separating fact from fiction on the controversial topic of leaky gut syndrome. We cover everything from what causes a leaky gut to interpreting the results of a gut microbiome test! Related links: Center for Celiac Research and Treatment website and their YouTube channel
Now Playing: Radiolab

The Flag and the Fury
How do you actually make change in the world? For 126 years, Mississippi has had the Confederate battle flag on their state flag, and they were the last state in the nation where that emblem remained "officially" flying.  A few days ago, that flag came down. A few days before that, it coming down would have seemed impossible. We dive into the story behind this de-flagging: a journey involving a clash of histories, designs, families, and even cheerleading. This show is a collaboration with OSM Audio. Kiese Laymon's memoir Heavy is here. And the Hospitality Flag webpage is here.